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Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasia.
Semin Cancer Biol 2009; 19(3):158-64SC

Abstract

Epstein-Barr virus (EBV), a human herpesvirus, is associated with a wide variety of malignant tumors. The expression of the latent viral RNAs is under strict, host-cell dependent transcriptional control. This results in an almost complete transcriptional silencing of the EBV genome in memory B-cells. In tumor cells, germinal center B-cells and lymphoblastoid cells, distinct viral latency promoters are active. Epigenetic mechanisms contribute to this strict control. In EBV-infected cells, epigenetic mechanisms also alter the expression of cellular genes, including tumor suppressor genes. In Nasopharyngeal Carcinoma, the hypermethylation of certain cellular promoters is attributed to the upregulation of DNA methyltransferases by the viral oncoprotein LMP1 (latent membrane protein 1) via JNK/AP1-signaling. The role of other viral latency products in the epigenetic dysregulation of the cellular genome remains to be established. Analysis of epigenetic alterations in EBV-associated neoplasms may result in a better understanding of their pathogenesis and may facilitate the development of new therapies.

Authors+Show Affiliations

Institute for Medical Microbiology and Hygiene at the University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany. Hans-Helmut.Niller@klinik.uni-regensburg.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19429479

Citation

Niller, Hans Helmut, et al. "Epigenetic Dysregulation of the Host Cell Genome in Epstein-Barr Virus-associated Neoplasia." Seminars in Cancer Biology, vol. 19, no. 3, 2009, pp. 158-64.
Niller HH, Wolf H, Minarovits J. Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasia. Semin Cancer Biol. 2009;19(3):158-64.
Niller, H. H., Wolf, H., & Minarovits, J. (2009). Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasia. Seminars in Cancer Biology, 19(3), pp. 158-64. doi:10.1016/j.semcancer.2009.02.012.
Niller HH, Wolf H, Minarovits J. Epigenetic Dysregulation of the Host Cell Genome in Epstein-Barr Virus-associated Neoplasia. Semin Cancer Biol. 2009;19(3):158-64. PubMed PMID: 19429479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasia. AU - Niller,Hans Helmut, AU - Wolf,Hans, AU - Minarovits,Janos, Y1 - 2009/02/24/ PY - 2008/12/18/received PY - 2009/02/13/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/6/27/medline SP - 158 EP - 64 JF - Seminars in cancer biology JO - Semin. Cancer Biol. VL - 19 IS - 3 N2 - Epstein-Barr virus (EBV), a human herpesvirus, is associated with a wide variety of malignant tumors. The expression of the latent viral RNAs is under strict, host-cell dependent transcriptional control. This results in an almost complete transcriptional silencing of the EBV genome in memory B-cells. In tumor cells, germinal center B-cells and lymphoblastoid cells, distinct viral latency promoters are active. Epigenetic mechanisms contribute to this strict control. In EBV-infected cells, epigenetic mechanisms also alter the expression of cellular genes, including tumor suppressor genes. In Nasopharyngeal Carcinoma, the hypermethylation of certain cellular promoters is attributed to the upregulation of DNA methyltransferases by the viral oncoprotein LMP1 (latent membrane protein 1) via JNK/AP1-signaling. The role of other viral latency products in the epigenetic dysregulation of the cellular genome remains to be established. Analysis of epigenetic alterations in EBV-associated neoplasms may result in a better understanding of their pathogenesis and may facilitate the development of new therapies. SN - 1096-3650 UR - https://www.unboundmedicine.com/medline/citation/19429479/Epigenetic_dysregulation_of_the_host_cell_genome_in_Epstein_Barr_virus_associated_neoplasia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-579X(09)00033-9 DB - PRIME DP - Unbound Medicine ER -