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Blood lead levels in children with encephalopathy.
Indian Pediatr. 2009 Oct; 46(10):845-8.IP

Abstract

OBJECTIVE

To determine the prevalence of elevated blood lead levels (EBLL i.e blood lead >10 micrograms/dL, Centers Disease Control criteria) in children with encephalopathy.

SETTING

Hospital.

DESIGN

Case control study.

PARTICIPANTS

100 children, 49 with encephalopathy and 51 consecutive hospital controls.

OUTCOME MEASURES

Blood lead levels, demographics, clinical, environmental correlates and residual neurological sequel or death at discharge.

RESULTS

42 (encephalopathy) and 49 (hospital controls) children were available for analysis. The overall (n=91) mean blood lead was 7.88+/-10.44 micrograms/dL (range 0.07-67.68 micrograms/dL). The predictors of EBLL were presence of wasting (P<0.03), anemia (P<0.04), use of surma (P< 0.02), recent removal of house paint (P<0.01) or recently repainted (P<0.01). The mean blood lead levels were significantly higher (P<0.01) in patients of encephalopathy (12.18+/- 13.90 micrograms/dL) than in controls (4.19+/- 2.84 micrograms/dL). EBLL was present in 3/17 (17.6%) patients with infective encephalopathy and in 18/25 (72%) with non-infective encephalopathy. The proportion of children with residual neurological sequelae, or death increased when associated with EBLL (0 to 21%, and 69% to 100% respectively).

CONCLUSION

Children hospitalized with encephalopathy have elevated blood lead levels.

Authors+Show Affiliations

Lata Medical Research Foundation, Nagpur, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19430083

Citation

Patel, Archana, and Ambarish Athawale. "Blood Lead Levels in Children With Encephalopathy." Indian Pediatrics, vol. 46, no. 10, 2009, pp. 845-8.
Patel A, Athawale A. Blood lead levels in children with encephalopathy. Indian Pediatr. 2009;46(10):845-8.
Patel, A., & Athawale, A. (2009). Blood lead levels in children with encephalopathy. Indian Pediatrics, 46(10), 845-8.
Patel A, Athawale A. Blood Lead Levels in Children With Encephalopathy. Indian Pediatr. 2009;46(10):845-8. PubMed PMID: 19430083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood lead levels in children with encephalopathy. AU - Patel,Archana, AU - Athawale,Ambarish, Y1 - 2009/04/01/ PY - 2007/07/25/received PY - 2008/11/06/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2010/2/23/medline SP - 845 EP - 8 JF - Indian pediatrics JO - Indian Pediatr VL - 46 IS - 10 N2 - OBJECTIVE: To determine the prevalence of elevated blood lead levels (EBLL i.e blood lead >10 micrograms/dL, Centers Disease Control criteria) in children with encephalopathy. SETTING: Hospital. DESIGN: Case control study. PARTICIPANTS: 100 children, 49 with encephalopathy and 51 consecutive hospital controls. OUTCOME MEASURES: Blood lead levels, demographics, clinical, environmental correlates and residual neurological sequel or death at discharge. RESULTS: 42 (encephalopathy) and 49 (hospital controls) children were available for analysis. The overall (n=91) mean blood lead was 7.88+/-10.44 micrograms/dL (range 0.07-67.68 micrograms/dL). The predictors of EBLL were presence of wasting (P<0.03), anemia (P<0.04), use of surma (P< 0.02), recent removal of house paint (P<0.01) or recently repainted (P<0.01). The mean blood lead levels were significantly higher (P<0.01) in patients of encephalopathy (12.18+/- 13.90 micrograms/dL) than in controls (4.19+/- 2.84 micrograms/dL). EBLL was present in 3/17 (17.6%) patients with infective encephalopathy and in 18/25 (72%) with non-infective encephalopathy. The proportion of children with residual neurological sequelae, or death increased when associated with EBLL (0 to 21%, and 69% to 100% respectively). CONCLUSION: Children hospitalized with encephalopathy have elevated blood lead levels. SN - 0974-7559 UR - https://www.unboundmedicine.com/medline/citation/19430083/Blood_lead_levels_in_children_with_encephalopathy_ L2 - http://www.indianpediatrics.net/oct2009/845.pdf DB - PRIME DP - Unbound Medicine ER -