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Stability of the mixture of technetium-99m human serum albumin and lidocaine hydrochloride for clinical application.
Nucl Med Commun. 2009 Jul; 30(7):494-7.NM

Abstract

AIM

To evaluate the stability of the mixture of technetium-99m (99mTc) human serum albumin (HSA) with the local anesthetic lidocaine hydrochloride.

MATERIALS AND METHODS

We assessed three preparations of the radiotracer, 99mTc-HSA, filtered 99mTc-HSA, and a mixture of 99mTc-HSA with lidocaine hydrochloride and then filtered. Time sequence evaluation was performed on all the specimens (n= 10) at 0, 30, 60, 90, 120, 150, and 180 min after preparation. Measurements of radiochemical purity as labeling stability and pH value change were conducted for each group of specimens.

RESULTS

We found no definite difference in the stability before and after the filtering procedure for 99mTc-HSA. However, we showed a decline of stability in the mixture of 99mTc-HSA with lidocaine. The filtered specimens showed a relatively higher pH value, towards a more neutral status, as compared with the unfiltered specimens.

CONCLUSION

Though pain relief for the patient receiving sentinel lymph node mapping is important, a preparation of a mixture of 99mTc-HSA and lidocaine may cause radiolabeling instability. Furthermore, compared with the filtered 99mTc-sulfur colloid, a filtering procedure does not change the labeling stability of the 99mTc-HSA. On the contrary, the filtered preparation was neutralized closer to the physiologic condition. For lymphoscintigraphic studies,our results suggested that pretreatment with local anesthesia followed by subdermal injection of a filtered 99mTc-HSA rather than a pre-mixture with lidocaine is appropriate for clinical application.

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Authors+Show Affiliations

Wang YF
Department of Nuclear Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, Taiwan.
Chuang MH
No affiliation info available
Cham TM
No affiliation info available
Chung MI
No affiliation info available

MeSH

Anesthetics, LocalDrug StabilityHumansHydrogen-Ion ConcentrationLidocaineStaining and LabelingTechnetium Tc 99m Aggregated AlbuminTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19430321

Citation

Wang, Yuh-Feng, et al. "Stability of the Mixture of Technetium-99m Human Serum Albumin and Lidocaine Hydrochloride for Clinical Application." Nuclear Medicine Communications, vol. 30, no. 7, 2009, pp. 494-7.
Wang YF, Chuang MH, Cham TM, et al. Stability of the mixture of technetium-99m human serum albumin and lidocaine hydrochloride for clinical application. Nucl Med Commun. 2009;30(7):494-7.
Wang, Y. F., Chuang, M. H., Cham, T. M., & Chung, M. I. (2009). Stability of the mixture of technetium-99m human serum albumin and lidocaine hydrochloride for clinical application. Nuclear Medicine Communications, 30(7), 494-7. https://doi.org/10.1097/MNM.0b013e32832b9a5c
Wang YF, et al. Stability of the Mixture of Technetium-99m Human Serum Albumin and Lidocaine Hydrochloride for Clinical Application. Nucl Med Commun. 2009;30(7):494-7. PubMed PMID: 19430321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of the mixture of technetium-99m human serum albumin and lidocaine hydrochloride for clinical application. AU - Wang,Yuh-Feng, AU - Chuang,Mei-Hua, AU - Cham,Thau-Ming, AU - Chung,Mei-Ing, PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/8/25/medline SP - 494 EP - 7 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 30 IS - 7 N2 - AIM: To evaluate the stability of the mixture of technetium-99m (99mTc) human serum albumin (HSA) with the local anesthetic lidocaine hydrochloride. MATERIALS AND METHODS: We assessed three preparations of the radiotracer, 99mTc-HSA, filtered 99mTc-HSA, and a mixture of 99mTc-HSA with lidocaine hydrochloride and then filtered. Time sequence evaluation was performed on all the specimens (n= 10) at 0, 30, 60, 90, 120, 150, and 180 min after preparation. Measurements of radiochemical purity as labeling stability and pH value change were conducted for each group of specimens. RESULTS: We found no definite difference in the stability before and after the filtering procedure for 99mTc-HSA. However, we showed a decline of stability in the mixture of 99mTc-HSA with lidocaine. The filtered specimens showed a relatively higher pH value, towards a more neutral status, as compared with the unfiltered specimens. CONCLUSION: Though pain relief for the patient receiving sentinel lymph node mapping is important, a preparation of a mixture of 99mTc-HSA and lidocaine may cause radiolabeling instability. Furthermore, compared with the filtered 99mTc-sulfur colloid, a filtering procedure does not change the labeling stability of the 99mTc-HSA. On the contrary, the filtered preparation was neutralized closer to the physiologic condition. For lymphoscintigraphic studies,our results suggested that pretreatment with local anesthesia followed by subdermal injection of a filtered 99mTc-HSA rather than a pre-mixture with lidocaine is appropriate for clinical application. SN - 1473-5628 UR - https://www.unboundmedicine.com/medline/citation/19430321/Stability_of_the_mixture_of_technetium_99m_human_serum_albumin_and_lidocaine_hydrochloride_for_clinical_application_ L2 - https://doi.org/10.1097/MNM.0b013e32832b9a5c DB - PRIME DP - Unbound Medicine ER -