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The use of B-type natriuretic peptide in paediatric patients: a review of literature.
J Cardiovasc Med (Hagerstown). 2009 Apr; 10(4):298-302.JC

Abstract

OBJECTIVE

Plasma levels of brain natriuretic peptide (BNP) and its inactive fragment N-terminal pro-BNP are recognized as reliable markers of ventricular dysfunction in adults. We aimed to verify BNP applications in children.

METHODS

A review of the literature on this subject was carried out.

RESULTS

When dealing with paediatric patients, age and sex-related normal values must be considered. Higher BNP plasma levels are reported in children with chronic heart failure; they are related with the type of dysfunction and with prognosis. Moreover, increased BNP levels have been reported in asymptomatic children and adolescents pretreated with anthracyclines, who are at risk for ventricular dysfunction.

CONCLUSION

BNP and pro-BNP also seem to be effective markers of ventricular dysfunction in paediatric patients. Clinical use may be extended not only for the characterization of heart dysfunction, but also for monitoring asymptomatic patients at specific risk. To this purpose, wider application in clinical trials appears warranted.

Authors+Show Affiliations

Pediatric Cardiology Unit, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19430339

Citation

Favilli, Silvia, et al. "The Use of B-type Natriuretic Peptide in Paediatric Patients: a Review of Literature." Journal of Cardiovascular Medicine (Hagerstown, Md.), vol. 10, no. 4, 2009, pp. 298-302.
Favilli S, Frenos S, Lasagni D, et al. The use of B-type natriuretic peptide in paediatric patients: a review of literature. J Cardiovasc Med (Hagerstown). 2009;10(4):298-302.
Favilli, S., Frenos, S., Lasagni, D., Frenos, F., Pollini, I., Bernini, G., Aricò, M., & Bini, R. M. (2009). The use of B-type natriuretic peptide in paediatric patients: a review of literature. Journal of Cardiovascular Medicine (Hagerstown, Md.), 10(4), 298-302. https://doi.org/10.2459/JCM.0b013e32832401d6
Favilli S, et al. The Use of B-type Natriuretic Peptide in Paediatric Patients: a Review of Literature. J Cardiovasc Med (Hagerstown). 2009;10(4):298-302. PubMed PMID: 19430339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of B-type natriuretic peptide in paediatric patients: a review of literature. AU - Favilli,Silvia, AU - Frenos,Stefano, AU - Lasagni,Donatella, AU - Frenos,Filippo, AU - Pollini,Iva, AU - Bernini,Gabriella, AU - Aricò,Maurizio, AU - Bini,Roberta M, PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/6/3/medline SP - 298 EP - 302 JF - Journal of cardiovascular medicine (Hagerstown, Md.) JO - J Cardiovasc Med (Hagerstown) VL - 10 IS - 4 N2 - OBJECTIVE: Plasma levels of brain natriuretic peptide (BNP) and its inactive fragment N-terminal pro-BNP are recognized as reliable markers of ventricular dysfunction in adults. We aimed to verify BNP applications in children. METHODS: A review of the literature on this subject was carried out. RESULTS: When dealing with paediatric patients, age and sex-related normal values must be considered. Higher BNP plasma levels are reported in children with chronic heart failure; they are related with the type of dysfunction and with prognosis. Moreover, increased BNP levels have been reported in asymptomatic children and adolescents pretreated with anthracyclines, who are at risk for ventricular dysfunction. CONCLUSION: BNP and pro-BNP also seem to be effective markers of ventricular dysfunction in paediatric patients. Clinical use may be extended not only for the characterization of heart dysfunction, but also for monitoring asymptomatic patients at specific risk. To this purpose, wider application in clinical trials appears warranted. SN - 1558-2027 UR - https://www.unboundmedicine.com/medline/citation/19430339/The_use_of_B_type_natriuretic_peptide_in_paediatric_patients:_a_review_of_literature_ L2 - http://dx.doi.org/10.2459/JCM.0b013e32832401d6 DB - PRIME DP - Unbound Medicine ER -