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Autoimmunity in autism.

Abstract

Autism spectrum disorders is a heterogenous group of neurodevelopmental disorders, the etiology or etiologies of which remain unknown. Increasing evidence of autoimmune phenomena in individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder, and this immune system dysfunction may represent novel targets for treatment. Furthermore, in recent studies, antibodies directed against the fetal brain have been detected in some mothers of children with autism; these antibodies have the ability to alter behavioral outcomes in the offspring of animal models. A better understanding of the involvement of the immune response in early brain development, with respect to autism, may have important therapeutic implications.

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  • Authors+Show Affiliations

    ,

    University of California at Davis, Department of Medical Microbiology and Immunology/UC Davis MIND Institute, 2805 50th Street, Sacramento, CA 95817, USA.

    ,

    Source

    MeSH

    Animals
    Autistic Disorder
    Autoimmune Diseases of the Nervous System
    Humans

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19431079

    Citation

    Enstrom, Amanda M., et al. "Autoimmunity in Autism." Current Opinion in Investigational Drugs (London, England : 2000), vol. 10, no. 5, 2009, pp. 463-73.
    Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in autism. Curr Opin Investig Drugs. 2009;10(5):463-73.
    Enstrom, A. M., Van de Water, J. A., & Ashwood, P. (2009). Autoimmunity in autism. Current Opinion in Investigational Drugs (London, England : 2000), 10(5), pp. 463-73.
    Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in Autism. Curr Opin Investig Drugs. 2009;10(5):463-73. PubMed PMID: 19431079.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Autoimmunity in autism. AU - Enstrom,Amanda M, AU - Van de Water,Judy A, AU - Ashwood,Paul, PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2010/1/27/medline SP - 463 EP - 73 JF - Current opinion in investigational drugs (London, England : 2000) JO - Curr Opin Investig Drugs VL - 10 IS - 5 N2 - Autism spectrum disorders is a heterogenous group of neurodevelopmental disorders, the etiology or etiologies of which remain unknown. Increasing evidence of autoimmune phenomena in individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder, and this immune system dysfunction may represent novel targets for treatment. Furthermore, in recent studies, antibodies directed against the fetal brain have been detected in some mothers of children with autism; these antibodies have the ability to alter behavioral outcomes in the offspring of animal models. A better understanding of the involvement of the immune response in early brain development, with respect to autism, may have important therapeutic implications. SN - 2040-3429 UR - https://www.unboundmedicine.com/medline/citation/19431079/Autoimmunity_in_autism_ L2 - http://www.diseaseinfosearch.org/result/673 DB - PRIME DP - Unbound Medicine ER -