Tags

Type your tag names separated by a space and hit enter

[Serum concentration of soluble adhesive molecules in patients with different forms of coronary artery disease].
Vojnosanit Pregl. 2009 Apr; 66(4):265-70.VP

Abstract

BACKGROUND/AIM

Vascular cell adhesion molecules-1 (VCAM-1) and intercellular cell adhesive molecules-1 (ICAM-1) play an important role in developing and progression of coronary atherosderosis. The aim of the paper was to compare concentrations of soluble forms of VCAM-1 and ICAM-1 in patients with different clinical presentations of coronary artery disease (CAD) and patients without CAD.

METHODS

Blood samples were taken from 25 patients with acute myocardial infarction (AMI), 25 patients with unstable angina pectoris (UAP), 25 with stable angina pectoris (SAP) and from 15 control patients without CAD, and concentrations of solubile adhesive molecules (VCAM-1, ICAM-1) were determined.

RESULTS

Obesity was more prominent in the NAP than in the SAP and the control patients (p < 0.05). There were no significant differences in gender distribution, age, duration of the CAD and body mass index between the groups. Hypertension and diabetes mellitus type 2 were more frequent in the CAD patients than in the controls (p < 0.01). Family history of the CAD was more frequent in the AMI and the UAP group than in the controls (p < 0.05). Serum concentrations of VCAM-1 was similar in the patients with AMI (955.9 +/- 117.8 ng/mL), UAP (952.4 +/- 139.1 ng/mL) and SAP (931 +/- 169.8 ng/mL), and significantly higher in these groups compared with the controls (823.4 +/- 97.6; p < 0.05, p < 0.05 and p < 0.1 respectively). Serum concentration of ICAM-1 was similar in the patients with AMI (699.2 +/- 125.6 ng/mL), UAP (727.6 +/- 171.8 ng/mL) and SAP (697.5 +/- 165.6 ng/mL), and significantly higher in these groups compared with the controls (583.4 +/- 86.6; p < 0.1, p < 0.05 and p < 0.1 respectively).

CONCLUSION

Increased concentrations of VCAM-1 and ICAM-1, as markers of inflammation, showed the importance of inflammatory processes in development of atherosclerosis and clinical expresion of CAD. Measurement of soluble ICAM-1 and VCAM-1 concentrations is a usefull indicator of atherosclerosis presence but not severity of CAD clinical presentation.

Authors+Show Affiliations

Vojna bolnica Nis, Interno odeljenje, Nis, Srbija. goran7328@bankerinter.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

srp

PubMed ID

19432291

Citation

Damnjanović, Goran, et al. "[Serum Concentration of Soluble Adhesive Molecules in Patients With Different Forms of Coronary Artery Disease]." Vojnosanitetski Pregled, vol. 66, no. 4, 2009, pp. 265-70.
Damnjanović G, Jelić M, Dindić B, et al. [Serum concentration of soluble adhesive molecules in patients with different forms of coronary artery disease]. Vojnosanit Pregl. 2009;66(4):265-70.
Damnjanović, G., Jelić, M., Dindić, B., & Ilić, S. (2009). [Serum concentration of soluble adhesive molecules in patients with different forms of coronary artery disease]. Vojnosanitetski Pregled, 66(4), 265-70.
Damnjanović G, et al. [Serum Concentration of Soluble Adhesive Molecules in Patients With Different Forms of Coronary Artery Disease]. Vojnosanit Pregl. 2009;66(4):265-70. PubMed PMID: 19432291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum concentration of soluble adhesive molecules in patients with different forms of coronary artery disease]. AU - Damnjanović,Goran, AU - Jelić,Marija, AU - Dindić,Boris, AU - Ilić,Stevan, PY - 2009/5/13/entrez PY - 2009/5/13/pubmed PY - 2009/6/6/medline SP - 265 EP - 70 JF - Vojnosanitetski pregled JO - Vojnosanit Pregl VL - 66 IS - 4 N2 - BACKGROUND/AIM: Vascular cell adhesion molecules-1 (VCAM-1) and intercellular cell adhesive molecules-1 (ICAM-1) play an important role in developing and progression of coronary atherosderosis. The aim of the paper was to compare concentrations of soluble forms of VCAM-1 and ICAM-1 in patients with different clinical presentations of coronary artery disease (CAD) and patients without CAD. METHODS: Blood samples were taken from 25 patients with acute myocardial infarction (AMI), 25 patients with unstable angina pectoris (UAP), 25 with stable angina pectoris (SAP) and from 15 control patients without CAD, and concentrations of solubile adhesive molecules (VCAM-1, ICAM-1) were determined. RESULTS: Obesity was more prominent in the NAP than in the SAP and the control patients (p < 0.05). There were no significant differences in gender distribution, age, duration of the CAD and body mass index between the groups. Hypertension and diabetes mellitus type 2 were more frequent in the CAD patients than in the controls (p < 0.01). Family history of the CAD was more frequent in the AMI and the UAP group than in the controls (p < 0.05). Serum concentrations of VCAM-1 was similar in the patients with AMI (955.9 +/- 117.8 ng/mL), UAP (952.4 +/- 139.1 ng/mL) and SAP (931 +/- 169.8 ng/mL), and significantly higher in these groups compared with the controls (823.4 +/- 97.6; p < 0.05, p < 0.05 and p < 0.1 respectively). Serum concentration of ICAM-1 was similar in the patients with AMI (699.2 +/- 125.6 ng/mL), UAP (727.6 +/- 171.8 ng/mL) and SAP (697.5 +/- 165.6 ng/mL), and significantly higher in these groups compared with the controls (583.4 +/- 86.6; p < 0.1, p < 0.05 and p < 0.1 respectively). CONCLUSION: Increased concentrations of VCAM-1 and ICAM-1, as markers of inflammation, showed the importance of inflammatory processes in development of atherosclerosis and clinical expresion of CAD. Measurement of soluble ICAM-1 and VCAM-1 concentrations is a usefull indicator of atherosclerosis presence but not severity of CAD clinical presentation. SN - 0042-8450 UR - https://www.unboundmedicine.com/medline/citation/19432291/[Serum_concentration_of_soluble_adhesive_molecules_in_patients_with_different_forms_of_coronary_artery_disease]_ L2 - https://antibodies.cancer.gov/detail/CPTC-CTNNBL1-1 DB - PRIME DP - Unbound Medicine ER -