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Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study.

Abstract

OBJECTIVE

To assess the relationship between baseline dietary fatty acids and 10-year incident age-related macular degeneration (AMD).

METHODS

In an elderly Australian cohort, 3654 participants were examined at baseline and 2454 were examined 5 and/or 10 years later. We assessed AMD from retinal photographs. Participants completed a semiquantitative food frequency questionnaire.

RESULTS

After adjusting for age, sex, and smoking, 1 serving of fish per week was associated with reduced risk of incident early AMD (relative risk, 0.69 [95% confidence interval, 0.49-0.98]), primarily among participants with less than the median linoleic acid consumption (0.57 [0.36-0.89]). Findings were similar for intake of long-chain omega-3 polyunsaturated fatty acids. One to 2 servings of nuts per week was associated with reduced risk of incident early AMD (relative risk, 0.65 [95% confidence interval, 0.47-0.91]). Protective associations between the intake of nuts and reduced risk of pigmentary abnormalities were seen among nonsmokers, participants with less than the median ratio of serum total to high-density lipoprotein cholesterol, and those with beta carotene intake greater than the median level.

CONCLUSIONS

This study provides evidence of protection against early AMD from regularly eating fish, greater consumption of omega-3 polyunsaturated fatty acids, and low intakes of foods rich in linoleic acid. Regular consumption of nuts may also reduce AMD risk. Joint effects from multiple factors are suggested.

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  • Authors+Show Affiliations

    ,

    Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia.

    , ,

    Source

    MeSH

    Aged
    Dietary Fats
    Eating
    Fatty Acids, Omega-3
    Feeding Behavior
    Female
    Fish Products
    Follow-Up Studies
    Humans
    Incidence
    Macular Degeneration
    Male
    Middle Aged
    New South Wales
    Nutrition Assessment
    Nuts
    Photography
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19433717

    Citation

    Tan, Jennifer S L., et al. "Dietary Fatty Acids and the 10-year Incidence of Age-related Macular Degeneration: the Blue Mountains Eye Study." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 127, no. 5, 2009, pp. 656-65.
    Tan JS, Wang JJ, Flood V, et al. Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. Arch Ophthalmol. 2009;127(5):656-65.
    Tan, J. S., Wang, J. J., Flood, V., & Mitchell, P. (2009). Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. Archives of Ophthalmology (Chicago, Ill. : 1960), 127(5), pp. 656-65. doi:10.1001/archophthalmol.2009.76.
    Tan JS, et al. Dietary Fatty Acids and the 10-year Incidence of Age-related Macular Degeneration: the Blue Mountains Eye Study. Arch Ophthalmol. 2009;127(5):656-65. PubMed PMID: 19433717.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. AU - Tan,Jennifer S L, AU - Wang,Jie Jin, AU - Flood,Victoria, AU - Mitchell,Paul, PY - 2009/5/13/entrez PY - 2009/5/13/pubmed PY - 2009/5/23/medline SP - 656 EP - 65 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 127 IS - 5 N2 - OBJECTIVE: To assess the relationship between baseline dietary fatty acids and 10-year incident age-related macular degeneration (AMD). METHODS: In an elderly Australian cohort, 3654 participants were examined at baseline and 2454 were examined 5 and/or 10 years later. We assessed AMD from retinal photographs. Participants completed a semiquantitative food frequency questionnaire. RESULTS: After adjusting for age, sex, and smoking, 1 serving of fish per week was associated with reduced risk of incident early AMD (relative risk, 0.69 [95% confidence interval, 0.49-0.98]), primarily among participants with less than the median linoleic acid consumption (0.57 [0.36-0.89]). Findings were similar for intake of long-chain omega-3 polyunsaturated fatty acids. One to 2 servings of nuts per week was associated with reduced risk of incident early AMD (relative risk, 0.65 [95% confidence interval, 0.47-0.91]). Protective associations between the intake of nuts and reduced risk of pigmentary abnormalities were seen among nonsmokers, participants with less than the median ratio of serum total to high-density lipoprotein cholesterol, and those with beta carotene intake greater than the median level. CONCLUSIONS: This study provides evidence of protection against early AMD from regularly eating fish, greater consumption of omega-3 polyunsaturated fatty acids, and low intakes of foods rich in linoleic acid. Regular consumption of nuts may also reduce AMD risk. Joint effects from multiple factors are suggested. SN - 1538-3601 UR - https://www.unboundmedicine.com/medline/citation/19433717/Dietary_fatty_acids_and_the_10_year_incidence_of_age_related_macular_degeneration:_the_Blue_Mountains_Eye_Study_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archophthalmol.2009.76 DB - PRIME DP - Unbound Medicine ER -