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Antihypertensive therapy with CCB/ARB combination in older individuals: focus on amlodipine/valsartan combination.
Am J Ther. 2010 Mar-Apr; 17(2):188-96.AJ

Abstract

Hypertension is highly prevalent and more difficult to treat in older individuals. Monotherapy alone is often not effective for the control of hypertension and single-pill combination therapy with 2 drugs having complementary mechanisms of action is needed in many older hypertensive individuals. The literature on management of hypertension in the elderly is reviewed, focusing on the efficacy of single-pill combination treatment with amlodipine and valsartan. Data from controlled clinical trials indicate that amlodipine/valsartan combination therapy was more effective in decreasing blood pressure than amlodipine monotherapy in older patients with stage 1 or stage 2 hypertension. This finding was also observed for older black hypertensive patients. In addition to reducing blood pressure, this combination therapy has demonstrated reduced incidence of peripheral edema, making it more acceptable to patients. In addition, due to metabolic neutrality of both components, this combination is preferable in patients with diabetes or metabolic syndrome. In conclusion, combination therapy, including single-pill combination therapy with amlodipine/valsartan, is particularly useful for the management of high-risk individuals such as the elderly.

Authors+Show Affiliations

Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, USA. kostis@umdnj.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19433970

Citation

Kostis, John B.. "Antihypertensive Therapy With CCB/ARB Combination in Older Individuals: Focus On Amlodipine/valsartan Combination." American Journal of Therapeutics, vol. 17, no. 2, 2010, pp. 188-96.
Kostis JB. Antihypertensive therapy with CCB/ARB combination in older individuals: focus on amlodipine/valsartan combination. Am J Ther. 2010;17(2):188-96.
Kostis, J. B. (2010). Antihypertensive therapy with CCB/ARB combination in older individuals: focus on amlodipine/valsartan combination. American Journal of Therapeutics, 17(2), 188-96. https://doi.org/10.1097/MJT.0b013e3181a2ba2d
Kostis JB. Antihypertensive Therapy With CCB/ARB Combination in Older Individuals: Focus On Amlodipine/valsartan Combination. Am J Ther. 2010 Mar-Apr;17(2):188-96. PubMed PMID: 19433970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihypertensive therapy with CCB/ARB combination in older individuals: focus on amlodipine/valsartan combination. A1 - Kostis,John B, PY - 2009/5/13/entrez PY - 2009/5/13/pubmed PY - 2010/7/2/medline SP - 188 EP - 96 JF - American journal of therapeutics JO - Am J Ther VL - 17 IS - 2 N2 - Hypertension is highly prevalent and more difficult to treat in older individuals. Monotherapy alone is often not effective for the control of hypertension and single-pill combination therapy with 2 drugs having complementary mechanisms of action is needed in many older hypertensive individuals. The literature on management of hypertension in the elderly is reviewed, focusing on the efficacy of single-pill combination treatment with amlodipine and valsartan. Data from controlled clinical trials indicate that amlodipine/valsartan combination therapy was more effective in decreasing blood pressure than amlodipine monotherapy in older patients with stage 1 or stage 2 hypertension. This finding was also observed for older black hypertensive patients. In addition to reducing blood pressure, this combination therapy has demonstrated reduced incidence of peripheral edema, making it more acceptable to patients. In addition, due to metabolic neutrality of both components, this combination is preferable in patients with diabetes or metabolic syndrome. In conclusion, combination therapy, including single-pill combination therapy with amlodipine/valsartan, is particularly useful for the management of high-risk individuals such as the elderly. SN - 1536-3686 UR - https://www.unboundmedicine.com/medline/citation/19433970/Antihypertensive_therapy_with_CCB/ARB_combination_in_older_individuals:_focus_on_amlodipine/valsartan_combination_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=19433970.ui DB - PRIME DP - Unbound Medicine ER -