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Developmental programming and hypertension.
Curr Opin Nephrol Hypertens 2009; 18(2):144-52CO

Abstract

PURPOSE OF REVIEW

There is a growing body of evidence linking adverse events or exposures during early life and adult-onset diseases. After important epidemiological studies from many parts of the world, research now focuses on mechanisms of organ dysfunction and on refining the understanding of the interaction between common elements of adverse perinatal conditions, such as nutrition, oxidants, and toxins exposures. This review will focus on advances in our comprehension of developmental programming of hypertension.

RECENT FINDINGS

Recent studies have unraveled important mechanisms of oligonephronia and impaired renal function, altered vascular function and structure as well as sympathetic regulation of the cardiovascular system. Furthermore, interactions between prenatal insults and postnatal conditions are the subject of intensive research. Prematurity vs. intrauterine growth restriction modulate differently programming of high blood pressure. Along with antenatal exposure to glucocorticoids and imbalanced nutrition, a critical role for perinatal oxidative stress is emerging.

SUMMARY

While the complexity of the interactions between antenatal and postnatal influences on adult blood pressure is increasingly recognized, the importance of postnatal life in (positively) modulating developmental programming offers the hope of a critical window of opportunity to reverse programming and prevent or reduce related adult-onset diseases.

Authors+Show Affiliations

Department of Pediatrics, Research Center, CHU Sainte-Justine, Université de Montréal, Canada. anne-monique.nuyt@recherche-ste-justine.qc.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19434052

Citation

Nuyt, Anne Monique, and Barbara T. Alexander. "Developmental Programming and Hypertension." Current Opinion in Nephrology and Hypertension, vol. 18, no. 2, 2009, pp. 144-52.
Nuyt AM, Alexander BT. Developmental programming and hypertension. Curr Opin Nephrol Hypertens. 2009;18(2):144-52.
Nuyt, A. M., & Alexander, B. T. (2009). Developmental programming and hypertension. Current Opinion in Nephrology and Hypertension, 18(2), pp. 144-52. doi:10.1097/MNH.0b013e328326092c.
Nuyt AM, Alexander BT. Developmental Programming and Hypertension. Curr Opin Nephrol Hypertens. 2009;18(2):144-52. PubMed PMID: 19434052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental programming and hypertension. AU - Nuyt,Anne Monique, AU - Alexander,Barbara T, PY - 2009/5/13/entrez PY - 2009/5/13/pubmed PY - 2009/7/16/medline SP - 144 EP - 52 JF - Current opinion in nephrology and hypertension JO - Curr. Opin. Nephrol. Hypertens. VL - 18 IS - 2 N2 - PURPOSE OF REVIEW: There is a growing body of evidence linking adverse events or exposures during early life and adult-onset diseases. After important epidemiological studies from many parts of the world, research now focuses on mechanisms of organ dysfunction and on refining the understanding of the interaction between common elements of adverse perinatal conditions, such as nutrition, oxidants, and toxins exposures. This review will focus on advances in our comprehension of developmental programming of hypertension. RECENT FINDINGS: Recent studies have unraveled important mechanisms of oligonephronia and impaired renal function, altered vascular function and structure as well as sympathetic regulation of the cardiovascular system. Furthermore, interactions between prenatal insults and postnatal conditions are the subject of intensive research. Prematurity vs. intrauterine growth restriction modulate differently programming of high blood pressure. Along with antenatal exposure to glucocorticoids and imbalanced nutrition, a critical role for perinatal oxidative stress is emerging. SUMMARY: While the complexity of the interactions between antenatal and postnatal influences on adult blood pressure is increasingly recognized, the importance of postnatal life in (positively) modulating developmental programming offers the hope of a critical window of opportunity to reverse programming and prevent or reduce related adult-onset diseases. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/19434052/Developmental_programming_and_hypertension L2 - http://Insights.ovid.com/pubmed?pmid=19434052 DB - PRIME DP - Unbound Medicine ER -