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Growth status in children and adolescents with sickle cell disease.
Pediatr Hematol Oncol 2009; 26(4):202-15PH

Abstract

OBJECTIVES

To assess the BMI status of children and adolescents with sickle cell disease (SCD) and determine if zBMI status during adolescence is predicted by gender, childhood zBMI status, disease genotype, and healthcare utilization (emergency department visits or hospitalizations).

STUDY DESIGN

Medical chart reviews were conducted on 133 patients followed through a regional Comprehensive Sickle Cell Center to obtain anthropometric measures and healthcare utilization data. Gender-specific BMI z-scores were calculated based on Centers for Disease Control (CDC) norms using Epi Info NutStat Software and SPSS generated syntax. Data were summarized categorically across two time periods for each participant: childhood (age 6-12 years) and adolescence (age 13-18 years).

RESULTS

Males were three times more likely to be underweight in adolescence compared to CDC norms, whereas females were three times more likely to be obese in adolescence. In addition, regression analyses indicated that BMI in adolescence was predicted by gender, average weight in childhood, and the average number of emergency department visits.

CONCLUSIONS

Children with SCD generally exhibit normal growth during childhood and adolescence, although 5-10% are at risk for poor growth or obesity. Prevention and intervention efforts should consider gender, average weight in childhood, and healthcare utilization factors.

Authors+Show Affiliations

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. Monica.Mitchell@cchmc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19437323

Citation

Mitchell, Monica J., et al. "Growth Status in Children and Adolescents With Sickle Cell Disease." Pediatric Hematology and Oncology, vol. 26, no. 4, 2009, pp. 202-15.
Mitchell MJ, Carpenter GJ, Crosby LE, et al. Growth status in children and adolescents with sickle cell disease. Pediatr Hematol Oncol. 2009;26(4):202-15.
Mitchell, M. J., Carpenter, G. J., Crosby, L. E., Bishop, C. T., Hines, J., & Noll, J. (2009). Growth status in children and adolescents with sickle cell disease. Pediatric Hematology and Oncology, 26(4), pp. 202-15. doi:10.1080/08880010902896882.
Mitchell MJ, et al. Growth Status in Children and Adolescents With Sickle Cell Disease. Pediatr Hematol Oncol. 2009;26(4):202-15. PubMed PMID: 19437323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth status in children and adolescents with sickle cell disease. AU - Mitchell,Monica J, AU - Carpenter,Gloria J O, AU - Crosby,Lori E, AU - Bishop,Chanelle T, AU - Hines,Janelle, AU - Noll,Jennie, PY - 2009/5/14/entrez PY - 2009/5/14/pubmed PY - 2009/6/27/medline SP - 202 EP - 15 JF - Pediatric hematology and oncology JO - Pediatr Hematol Oncol VL - 26 IS - 4 N2 - OBJECTIVES: To assess the BMI status of children and adolescents with sickle cell disease (SCD) and determine if zBMI status during adolescence is predicted by gender, childhood zBMI status, disease genotype, and healthcare utilization (emergency department visits or hospitalizations). STUDY DESIGN: Medical chart reviews were conducted on 133 patients followed through a regional Comprehensive Sickle Cell Center to obtain anthropometric measures and healthcare utilization data. Gender-specific BMI z-scores were calculated based on Centers for Disease Control (CDC) norms using Epi Info NutStat Software and SPSS generated syntax. Data were summarized categorically across two time periods for each participant: childhood (age 6-12 years) and adolescence (age 13-18 years). RESULTS: Males were three times more likely to be underweight in adolescence compared to CDC norms, whereas females were three times more likely to be obese in adolescence. In addition, regression analyses indicated that BMI in adolescence was predicted by gender, average weight in childhood, and the average number of emergency department visits. CONCLUSIONS: Children with SCD generally exhibit normal growth during childhood and adolescence, although 5-10% are at risk for poor growth or obesity. Prevention and intervention efforts should consider gender, average weight in childhood, and healthcare utilization factors. SN - 1521-0669 UR - https://www.unboundmedicine.com/medline/citation/19437323/Growth_status_in_children_and_adolescents_with_sickle_cell_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/08880010902896882 DB - PRIME DP - Unbound Medicine ER -