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Growth status in children and adolescents with sickle cell disease.

Abstract

OBJECTIVES

To assess the BMI status of children and adolescents with sickle cell disease (SCD) and determine if zBMI status during adolescence is predicted by gender, childhood zBMI status, disease genotype, and healthcare utilization (emergency department visits or hospitalizations).

STUDY DESIGN

Medical chart reviews were conducted on 133 patients followed through a regional Comprehensive Sickle Cell Center to obtain anthropometric measures and healthcare utilization data. Gender-specific BMI z-scores were calculated based on Centers for Disease Control (CDC) norms using Epi Info NutStat Software and SPSS generated syntax. Data were summarized categorically across two time periods for each participant: childhood (age 6-12 years) and adolescence (age 13-18 years).

RESULTS

Males were three times more likely to be underweight in adolescence compared to CDC norms, whereas females were three times more likely to be obese in adolescence. In addition, regression analyses indicated that BMI in adolescence was predicted by gender, average weight in childhood, and the average number of emergency department visits.

CONCLUSIONS

Children with SCD generally exhibit normal growth during childhood and adolescence, although 5-10% are at risk for poor growth or obesity. Prevention and intervention efforts should consider gender, average weight in childhood, and healthcare utilization factors.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. Monica.Mitchell@cchmc.org

    , , , ,

    Source

    Pediatric hematology and oncology 26:4 2009 Jun pg 202-15

    MeSH

    Adolescent
    Adolescent Development
    Anemia, Sickle Cell
    Anthropometry
    Body Mass Index
    Body Weight
    Child
    Child Development
    Female
    Humans
    Male
    Obesity
    Sex Factors
    Thinness

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19437323

    Citation

    TY - JOUR T1 - Growth status in children and adolescents with sickle cell disease. AU - Mitchell,Monica J, AU - Carpenter,Gloria J O, AU - Crosby,Lori E, AU - Bishop,Chanelle T, AU - Hines,Janelle, AU - Noll,Jennie, PY - 2009/5/14/entrez PY - 2009/5/14/pubmed PY - 2009/6/27/medline SP - 202 EP - 15 JF - Pediatric hematology and oncology JO - Pediatr Hematol Oncol VL - 26 IS - 4 N2 - OBJECTIVES: To assess the BMI status of children and adolescents with sickle cell disease (SCD) and determine if zBMI status during adolescence is predicted by gender, childhood zBMI status, disease genotype, and healthcare utilization (emergency department visits or hospitalizations). STUDY DESIGN: Medical chart reviews were conducted on 133 patients followed through a regional Comprehensive Sickle Cell Center to obtain anthropometric measures and healthcare utilization data. Gender-specific BMI z-scores were calculated based on Centers for Disease Control (CDC) norms using Epi Info NutStat Software and SPSS generated syntax. Data were summarized categorically across two time periods for each participant: childhood (age 6-12 years) and adolescence (age 13-18 years). RESULTS: Males were three times more likely to be underweight in adolescence compared to CDC norms, whereas females were three times more likely to be obese in adolescence. In addition, regression analyses indicated that BMI in adolescence was predicted by gender, average weight in childhood, and the average number of emergency department visits. CONCLUSIONS: Children with SCD generally exhibit normal growth during childhood and adolescence, although 5-10% are at risk for poor growth or obesity. Prevention and intervention efforts should consider gender, average weight in childhood, and healthcare utilization factors. SN - 1521-0669 UR - https://www.unboundmedicine.com/medline/citation/19437323/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/08880010902896882 ER -