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Integrating glycaemic variability in the glycaemic disorders of type 2 diabetes: a move towards a unified glucose tetrad concept.
Diabetes Metab Res Rev. 2009 Jul; 25(5):393-402.DM

Abstract

The high incidence of atherosclerosis and cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes. Evidence is accumulating that postprandial hyperglycaemia is an independent risk factor for diabetes-associated complications and mortality, and that worsening diabetes control is characterized by postprandial glucose (PPG) deterioration preceding an impairment in fasting glucose levels. Postprandial and general glucose fluctuations play a major role in activating oxidative stress, leading to the endothelial dysfunction, one of the mechanisms responsible for vascular complications. Therefore, the management of PPG is key for any strategy used in the monitoring and treatment of diabetes. We recommend that any strategy aimed at controlling the glycaemic disorders associated with type 2 diabetes, and limiting the risk of complications, should target the 'glucose tetrad', which comprises the following components: HbA(1c), fasting and postprandial plasma glucose, and markers of glycaemic variability, such as the mean amplitude of glycaemic excursions (MAGE) index. This brings together, in a simple, unified concept, the conventional markers (HbA(1c) and fasting glucose) and the more recently recognized markers of glycaemic control (PPG excursions and acute glycaemic variability).

Authors+Show Affiliations

Department of Metabolic Diseases, Lapeyronie Hospital, Montpellier, France. l-monnier@chu-montpellier.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19437415

Citation

Monnier, Louis, et al. "Integrating Glycaemic Variability in the Glycaemic Disorders of Type 2 Diabetes: a Move Towards a Unified Glucose Tetrad Concept." Diabetes/metabolism Research and Reviews, vol. 25, no. 5, 2009, pp. 393-402.
Monnier L, Colette C, Owens DR. Integrating glycaemic variability in the glycaemic disorders of type 2 diabetes: a move towards a unified glucose tetrad concept. Diabetes Metab Res Rev. 2009;25(5):393-402.
Monnier, L., Colette, C., & Owens, D. R. (2009). Integrating glycaemic variability in the glycaemic disorders of type 2 diabetes: a move towards a unified glucose tetrad concept. Diabetes/metabolism Research and Reviews, 25(5), 393-402. https://doi.org/10.1002/dmrr.962
Monnier L, Colette C, Owens DR. Integrating Glycaemic Variability in the Glycaemic Disorders of Type 2 Diabetes: a Move Towards a Unified Glucose Tetrad Concept. Diabetes Metab Res Rev. 2009;25(5):393-402. PubMed PMID: 19437415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integrating glycaemic variability in the glycaemic disorders of type 2 diabetes: a move towards a unified glucose tetrad concept. AU - Monnier,Louis, AU - Colette,Claude, AU - Owens,David R, PY - 2009/5/14/entrez PY - 2009/5/14/pubmed PY - 2009/11/3/medline SP - 393 EP - 402 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab Res Rev VL - 25 IS - 5 N2 - The high incidence of atherosclerosis and cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes. Evidence is accumulating that postprandial hyperglycaemia is an independent risk factor for diabetes-associated complications and mortality, and that worsening diabetes control is characterized by postprandial glucose (PPG) deterioration preceding an impairment in fasting glucose levels. Postprandial and general glucose fluctuations play a major role in activating oxidative stress, leading to the endothelial dysfunction, one of the mechanisms responsible for vascular complications. Therefore, the management of PPG is key for any strategy used in the monitoring and treatment of diabetes. We recommend that any strategy aimed at controlling the glycaemic disorders associated with type 2 diabetes, and limiting the risk of complications, should target the 'glucose tetrad', which comprises the following components: HbA(1c), fasting and postprandial plasma glucose, and markers of glycaemic variability, such as the mean amplitude of glycaemic excursions (MAGE) index. This brings together, in a simple, unified concept, the conventional markers (HbA(1c) and fasting glucose) and the more recently recognized markers of glycaemic control (PPG excursions and acute glycaemic variability). SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/19437415/Integrating_glycaemic_variability_in_the_glycaemic_disorders_of_type_2_diabetes:_a_move_towards_a_unified_glucose_tetrad_concept_ DB - PRIME DP - Unbound Medicine ER -