Tags

Type your tag names separated by a space and hit enter

Isolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis.
Br J Dermatol. 2009 Aug; 161(2):300-5.BJ

Abstract

BACKGROUND

Staphylococcus aureus (S. aureus) is a well-known trigger factor of atopic dermatitis (AD). Besides staphylococcal superantigens, alpha-toxin may influence cutaneous inflammation via induction of T-cell proliferation and cytokine secretion.

OBJECTIVES

To investigate the association between sensitization to inhalant allergens and skin colonization with alpha-toxin-producing S. aureus in AD.

PATIENTS AND METHODS

We investigated 127 patients with AD, aged 14-65 years, who were on standard anti-inflammatory and antiseptic treatment before investigation. We evaluated skin colonization, medical history, severity of AD and sensitization to inhalant allergens.

RESULTS

Forty-eight of 127 patients were colonized with S. aureus, suffered from more severe AD, had asthma more often and showed higher sensitization levels to inhalant allergens. Thirty of 48 patients with S. aureus skin-colonizing strains produced alpha-toxin and had higher total IgE and specific IgE to birch pollen and timothy grass pollen.

CONCLUSIONS

Under topical treatment with antiseptic and anti-inflammatory agents the colonization of lesional skin with S. aureus was clearly lower than commonly found in untreated patients with AD. Colonization with S. aureus was associated with a higher severity of AD, higher degree of sensitization, and a higher frequency of asthma. The proportion of patients whose skin was colonized with alpha-toxin-producing S. aureus was higher than expected from a former study. Cutaneous colonization with alpha-toxin-producing S. aureus was associated with a higher sensitization level to birch pollen allergen in AD. This may point to a higher susceptibility of patients with higher T-helper 2 polarization towards alpha-toxin-producing S. aureus.

Authors+Show Affiliations

Department of Immunodermatology and Allergy Research, Hannover Medical School, Ricklinger Str. 5, 30449 Hannover, Germany. wichmann.katja@mh-hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19438853

Citation

Wichmann, K, et al. "Isolation of Alpha-toxin-producing Staphylococcus Aureus From the Skin of Highly Sensitized Adult Patients With Severe Atopic Dermatitis." The British Journal of Dermatology, vol. 161, no. 2, 2009, pp. 300-5.
Wichmann K, Uter W, Weiss J, et al. Isolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. Br J Dermatol. 2009;161(2):300-5.
Wichmann, K., Uter, W., Weiss, J., Breuer, K., Heratizadeh, A., Mai, U., & Werfel, T. (2009). Isolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. The British Journal of Dermatology, 161(2), 300-5. https://doi.org/10.1111/j.1365-2133.2009.09229.x
Wichmann K, et al. Isolation of Alpha-toxin-producing Staphylococcus Aureus From the Skin of Highly Sensitized Adult Patients With Severe Atopic Dermatitis. Br J Dermatol. 2009;161(2):300-5. PubMed PMID: 19438853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. AU - Wichmann,K, AU - Uter,W, AU - Weiss,J, AU - Breuer,K, AU - Heratizadeh,A, AU - Mai,U, AU - Werfel,T, Y1 - 2009/05/12/ PY - 2009/5/15/entrez PY - 2009/5/15/pubmed PY - 2009/12/25/medline SP - 300 EP - 5 JF - The British journal of dermatology JO - Br J Dermatol VL - 161 IS - 2 N2 - BACKGROUND: Staphylococcus aureus (S. aureus) is a well-known trigger factor of atopic dermatitis (AD). Besides staphylococcal superantigens, alpha-toxin may influence cutaneous inflammation via induction of T-cell proliferation and cytokine secretion. OBJECTIVES: To investigate the association between sensitization to inhalant allergens and skin colonization with alpha-toxin-producing S. aureus in AD. PATIENTS AND METHODS: We investigated 127 patients with AD, aged 14-65 years, who were on standard anti-inflammatory and antiseptic treatment before investigation. We evaluated skin colonization, medical history, severity of AD and sensitization to inhalant allergens. RESULTS: Forty-eight of 127 patients were colonized with S. aureus, suffered from more severe AD, had asthma more often and showed higher sensitization levels to inhalant allergens. Thirty of 48 patients with S. aureus skin-colonizing strains produced alpha-toxin and had higher total IgE and specific IgE to birch pollen and timothy grass pollen. CONCLUSIONS: Under topical treatment with antiseptic and anti-inflammatory agents the colonization of lesional skin with S. aureus was clearly lower than commonly found in untreated patients with AD. Colonization with S. aureus was associated with a higher severity of AD, higher degree of sensitization, and a higher frequency of asthma. The proportion of patients whose skin was colonized with alpha-toxin-producing S. aureus was higher than expected from a former study. Cutaneous colonization with alpha-toxin-producing S. aureus was associated with a higher sensitization level to birch pollen allergen in AD. This may point to a higher susceptibility of patients with higher T-helper 2 polarization towards alpha-toxin-producing S. aureus. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/19438853/Isolation_of_alpha_toxin_producing_Staphylococcus_aureus_from_the_skin_of_highly_sensitized_adult_patients_with_severe_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1365-2133.2009.09229.x DB - PRIME DP - Unbound Medicine ER -