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Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma.
Hum Pathol. 2009 Sep; 40(9):1224-33.HP

Abstract

To analyze the expression and prognostic value of matrix metalloproteases and their tissue inhibitors in luminal A and basal-like breast carcinomas, an immunohistochemical study was performed on cancer specimens from 93 randomly selected patients with invasive primary ductal tumors of the breast (46 with and 47 without distant metastasis) and with luminal A (n = 48) (ER+, HER2-) or basal-like (HER2-, ER-, PgR-) (n = 45) lesions. Luminal B cases were too few to analyze. Specimens were also studied using tissue microarrays and specific antibodies against matrix metalloproteases 1, 2, 7, 9, 11, 13, and 14 and tissue inhibitors 1, 2, and 3. There were no significant differences in matrix metalloprotease or tissue inhibitor expression in the 2 phenotypes of tumors. In basal-like carcinomas, high scores for matrix metalloproteases 9 and 11 were significantly associated with a high distant metastasis rate. Likewise, data showed associations between matrix metalloprotease/tissue inhibitor expression by either stromal fibroblasts or mononuclear inflammatory cells and distant relapse-free survival in both tumor phenotypes. In addition, in infiltrating luminal A and basal-like tumors, we identified a prometastatic phenotype of mononuclear inflammatory cells, showing a high matrix metalloprotease/tissue inhibitor molecular profile. Expression of matrix metalloproteases and tissue inhibitors is related to the characteristics of breast tumor cells. As prognostic factors in breast carcinomas of both luminal A and basal-like phenotypes, our results point to the importance of the expression of matrix metalloproteases and tissue inhibitors by the stromal cells.

Authors+Show Affiliations

Unidad de Investigación, Hospital de Jove, 33290 Gijón, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19439346

Citation

González, Luis O., et al. "Expression and Prognostic Significance of Metalloproteases and Their Inhibitors in Luminal a and Basal-like Phenotypes of Breast Carcinoma." Human Pathology, vol. 40, no. 9, 2009, pp. 1224-33.
González LO, Corte MD, Junquera S, et al. Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma. Hum Pathol. 2009;40(9):1224-33.
González, L. O., Corte, M. D., Junquera, S., González-Fernández, R., del Casar, J. M., García, C., Andicoechea, A., Vázquez, J., Pérez-Fernández, R., & Vizoso, F. J. (2009). Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma. Human Pathology, 40(9), 1224-33. https://doi.org/10.1016/j.humpath.2008.12.022
González LO, et al. Expression and Prognostic Significance of Metalloproteases and Their Inhibitors in Luminal a and Basal-like Phenotypes of Breast Carcinoma. Hum Pathol. 2009;40(9):1224-33. PubMed PMID: 19439346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma. AU - González,Luis O, AU - Corte,María D, AU - Junquera,Sara, AU - González-Fernández,Raquel, AU - del Casar,José M, AU - García,Carmen, AU - Andicoechea,Alejandro, AU - Vázquez,Julio, AU - Pérez-Fernández,Román, AU - Vizoso,Francisco J, Y1 - 2009/05/12/ PY - 2008/09/02/received PY - 2008/12/01/revised PY - 2008/12/03/accepted PY - 2009/5/15/entrez PY - 2009/5/15/pubmed PY - 2009/9/9/medline SP - 1224 EP - 33 JF - Human pathology JO - Hum Pathol VL - 40 IS - 9 N2 - To analyze the expression and prognostic value of matrix metalloproteases and their tissue inhibitors in luminal A and basal-like breast carcinomas, an immunohistochemical study was performed on cancer specimens from 93 randomly selected patients with invasive primary ductal tumors of the breast (46 with and 47 without distant metastasis) and with luminal A (n = 48) (ER+, HER2-) or basal-like (HER2-, ER-, PgR-) (n = 45) lesions. Luminal B cases were too few to analyze. Specimens were also studied using tissue microarrays and specific antibodies against matrix metalloproteases 1, 2, 7, 9, 11, 13, and 14 and tissue inhibitors 1, 2, and 3. There were no significant differences in matrix metalloprotease or tissue inhibitor expression in the 2 phenotypes of tumors. In basal-like carcinomas, high scores for matrix metalloproteases 9 and 11 were significantly associated with a high distant metastasis rate. Likewise, data showed associations between matrix metalloprotease/tissue inhibitor expression by either stromal fibroblasts or mononuclear inflammatory cells and distant relapse-free survival in both tumor phenotypes. In addition, in infiltrating luminal A and basal-like tumors, we identified a prometastatic phenotype of mononuclear inflammatory cells, showing a high matrix metalloprotease/tissue inhibitor molecular profile. Expression of matrix metalloproteases and tissue inhibitors is related to the characteristics of breast tumor cells. As prognostic factors in breast carcinomas of both luminal A and basal-like phenotypes, our results point to the importance of the expression of matrix metalloproteases and tissue inhibitors by the stromal cells. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/19439346/Expression_and_prognostic_significance_of_metalloproteases_and_their_inhibitors_in_luminal_A_and_basal_like_phenotypes_of_breast_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(09)00075-6 DB - PRIME DP - Unbound Medicine ER -