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Very high-dose clozapine and electroconvulsive therapy combination treatment in a patient with schizophrenia.
J ECT. 2009 Dec; 25(4):280-1.JE

Abstract

We report here the case of a 19-year-old man with paranoid schizophrenia who responded only partially to treatment with daily doses of clozapine, 1800 mg; aripiprazole, 20 mg; and clonazepam, 6 mg. We reduced the clozapine to 1600 to 1700 mg, maintaining therapeutic serum levels, and added a course of electroconvulsive therapy that included 24 treatments. Therapeutic results were minimal. However, adverse effects were limited to mild cognitive disturbances. Our experience adds to other reports suggesting that clozapine and electroconvulsive therapy can be combined without causing excessive adverse effects.

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Authors+Show Affiliations

Keller S
Department of Psychiatry, Sarah Herzog Memorial Hospital, Jerusalem, Israel. shikmak@gmail.com
Drexler H
No affiliation info available
Lichtenberg P
No affiliation info available

MeSH

Antipsychotic AgentsClozapineCombined Modality TherapyConfusionElectroconvulsive TherapyHumansMaleMemory DisordersPsychiatric Status Rating ScalesSchizophrenia, ParanoidYoung Adult

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19440159

Citation

Keller, Shikma, et al. "Very High-dose Clozapine and Electroconvulsive Therapy Combination Treatment in a Patient With Schizophrenia." The Journal of ECT, vol. 25, no. 4, 2009, pp. 280-1.
Keller S, Drexler H, Lichtenberg P. Very high-dose clozapine and electroconvulsive therapy combination treatment in a patient with schizophrenia. J ECT. 2009;25(4):280-1.
Keller, S., Drexler, H., & Lichtenberg, P. (2009). Very high-dose clozapine and electroconvulsive therapy combination treatment in a patient with schizophrenia. The Journal of ECT, 25(4), 280-1. https://doi.org/10.1097/YCT.0b013e3181a2f867
Keller S, Drexler H, Lichtenberg P. Very High-dose Clozapine and Electroconvulsive Therapy Combination Treatment in a Patient With Schizophrenia. J ECT. 2009;25(4):280-1. PubMed PMID: 19440159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Very high-dose clozapine and electroconvulsive therapy combination treatment in a patient with schizophrenia. AU - Keller,Shikma, AU - Drexler,Heinz, AU - Lichtenberg,Pesach, PY - 2009/5/15/entrez PY - 2009/5/15/pubmed PY - 2010/2/18/medline SP - 280 EP - 1 JF - The journal of ECT JO - J ECT VL - 25 IS - 4 N2 - We report here the case of a 19-year-old man with paranoid schizophrenia who responded only partially to treatment with daily doses of clozapine, 1800 mg; aripiprazole, 20 mg; and clonazepam, 6 mg. We reduced the clozapine to 1600 to 1700 mg, maintaining therapeutic serum levels, and added a course of electroconvulsive therapy that included 24 treatments. Therapeutic results were minimal. However, adverse effects were limited to mild cognitive disturbances. Our experience adds to other reports suggesting that clozapine and electroconvulsive therapy can be combined without causing excessive adverse effects. SN - 1533-4112 UR - https://www.unboundmedicine.com/medline/citation/19440159/Very_high_dose_clozapine_and_electroconvulsive_therapy_combination_treatment_in_a_patient_with_schizophrenia_ L2 - https://doi.org/10.1097/YCT.0b013e3181a2f867 DB - PRIME DP - Unbound Medicine ER -