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Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans.
Clin Pharmacol Ther 2009; 86(2):160-6CP

Abstract

This study assessed the acute physiologic effects over time of (co)administration of Delta9-tetrahydrocannabinol (Delta9-THC) (the main psychoactive compound of cannabis) and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in 16 healthy volunteers. Pharmacokinetics and cardiovascular, temperature, and catecholamine responses were assessed over time. Both single-drug conditions robustly increased heart rate, and coadministration showed additive effects. MDMA increased epinephrine and norepinephrine concentrations, whereas THC did not affect the catecholamine response. Coadministration of MDMA and THC attenuated the increase of norepinephrine concentrations relative to administration of MDMA alone. These results show that THC mediates heart rate increase independent of sympathetic (catecholaminergic) activity, probably through direct cannabinoid receptor type 1 (CB(1)) agonism in cardiac tissue. Furthermore, THC coadministration did not prevent MDMA-induced temperature increase, but it delayed the onset and prolonged the duration of temperature elevation. These effects may be of particular relevance for the cardiovascular safety of ecstasy users who participate in energetic dancing in nightclubs with high ambient temperature.

Authors+Show Affiliations

Department of Psychiatry, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. g.j.h.dumont@psy.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19440186

Citation

Dumont, G J., et al. "Cannabis Coadministration Potentiates the Effects of "ecstasy" On Heart Rate and Temperature in Humans." Clinical Pharmacology and Therapeutics, vol. 86, no. 2, 2009, pp. 160-6.
Dumont GJ, Kramers C, Sweep FC, et al. Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans. Clin Pharmacol Ther. 2009;86(2):160-6.
Dumont, G. J., Kramers, C., Sweep, F. C., Touw, D. J., van Hasselt, J. G., de Kam, M., ... Verkes, R. J. (2009). Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans. Clinical Pharmacology and Therapeutics, 86(2), pp. 160-6. doi:10.1038/clpt.2009.62.
Dumont GJ, et al. Cannabis Coadministration Potentiates the Effects of "ecstasy" On Heart Rate and Temperature in Humans. Clin Pharmacol Ther. 2009;86(2):160-6. PubMed PMID: 19440186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans. AU - Dumont,G J, AU - Kramers,C, AU - Sweep,F C, AU - Touw,D J, AU - van Hasselt,J G, AU - de Kam,M, AU - van Gerven,J M, AU - Buitelaar,J K, AU - Verkes,R J, Y1 - 2009/05/13/ PY - 2009/5/15/entrez PY - 2009/5/15/pubmed PY - 2009/8/6/medline SP - 160 EP - 6 JF - Clinical pharmacology and therapeutics JO - Clin. Pharmacol. Ther. VL - 86 IS - 2 N2 - This study assessed the acute physiologic effects over time of (co)administration of Delta9-tetrahydrocannabinol (Delta9-THC) (the main psychoactive compound of cannabis) and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in 16 healthy volunteers. Pharmacokinetics and cardiovascular, temperature, and catecholamine responses were assessed over time. Both single-drug conditions robustly increased heart rate, and coadministration showed additive effects. MDMA increased epinephrine and norepinephrine concentrations, whereas THC did not affect the catecholamine response. Coadministration of MDMA and THC attenuated the increase of norepinephrine concentrations relative to administration of MDMA alone. These results show that THC mediates heart rate increase independent of sympathetic (catecholaminergic) activity, probably through direct cannabinoid receptor type 1 (CB(1)) agonism in cardiac tissue. Furthermore, THC coadministration did not prevent MDMA-induced temperature increase, but it delayed the onset and prolonged the duration of temperature elevation. These effects may be of particular relevance for the cardiovascular safety of ecstasy users who participate in energetic dancing in nightclubs with high ambient temperature. SN - 1532-6535 UR - https://www.unboundmedicine.com/medline/citation/19440186/abstract/Cannabis_Coadministration_Po L2 - https://doi.org/10.1038/clpt.2009.62 DB - PRIME DP - Unbound Medicine ER -