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Gold-nanoparticle-supported silicon plate with polymer micelles for surface-assisted laser desorption/ionization mass spectrometry of peptides.
J Nanosci Nanotechnol. 2009 Jan; 9(1):159-64.JN

Abstract

We developed surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using nanocomposite films of cationic diblock copolymer micelles [poly(styrene-b-N-methyl-4-vinyl pyridinium iodide)] and ammonium citrated Au nanoparticles (AuNPs) on silicon. The nanocomposite film on silicon was suitable for use as a material for matrix-free LDI-MS of peptides due to its low matrix background from Au clusters and high ionization efficiency; this plate successfully ionized angiotensin I, and also insulin in the proton adduct forms, in contrast to methods using only AuNPs and those using nanocomposite films of cationic polymer in conjunction with Au NPs. The high ionization efficiency is discussed from the viewpoint of nanoparticle distribution controlled by polymers on the plate (aggregates vs. nonaggregates).

Authors+Show Affiliations

Department of Applied Chemistry, Kansai University, Suita, Osaka 564-8680, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19441290

Citation

Tarui, Akira, et al. "Gold-nanoparticle-supported Silicon Plate With Polymer Micelles for Surface-assisted Laser Desorption/ionization Mass Spectrometry of Peptides." Journal of Nanoscience and Nanotechnology, vol. 9, no. 1, 2009, pp. 159-64.
Tarui A, Kawasaki H, Taiko T, et al. Gold-nanoparticle-supported silicon plate with polymer micelles for surface-assisted laser desorption/ionization mass spectrometry of peptides. J Nanosci Nanotechnol. 2009;9(1):159-64.
Tarui, A., Kawasaki, H., Taiko, T., Watanabe, T., Yonezawa, T., & Arakawa, R. (2009). Gold-nanoparticle-supported silicon plate with polymer micelles for surface-assisted laser desorption/ionization mass spectrometry of peptides. Journal of Nanoscience and Nanotechnology, 9(1), 159-64.
Tarui A, et al. Gold-nanoparticle-supported Silicon Plate With Polymer Micelles for Surface-assisted Laser Desorption/ionization Mass Spectrometry of Peptides. J Nanosci Nanotechnol. 2009;9(1):159-64. PubMed PMID: 19441290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gold-nanoparticle-supported silicon plate with polymer micelles for surface-assisted laser desorption/ionization mass spectrometry of peptides. AU - Tarui,Akira, AU - Kawasaki,Hideya, AU - Taiko,Takuma, AU - Watanabe,Takehiro, AU - Yonezawa,Tetsu, AU - Arakawa,Ryuichi, PY - 2009/5/16/entrez PY - 2009/5/16/pubmed PY - 2009/6/11/medline SP - 159 EP - 64 JF - Journal of nanoscience and nanotechnology JO - J Nanosci Nanotechnol VL - 9 IS - 1 N2 - We developed surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using nanocomposite films of cationic diblock copolymer micelles [poly(styrene-b-N-methyl-4-vinyl pyridinium iodide)] and ammonium citrated Au nanoparticles (AuNPs) on silicon. The nanocomposite film on silicon was suitable for use as a material for matrix-free LDI-MS of peptides due to its low matrix background from Au clusters and high ionization efficiency; this plate successfully ionized angiotensin I, and also insulin in the proton adduct forms, in contrast to methods using only AuNPs and those using nanocomposite films of cationic polymer in conjunction with Au NPs. The high ionization efficiency is discussed from the viewpoint of nanoparticle distribution controlled by polymers on the plate (aggregates vs. nonaggregates). SN - 1533-4880 UR - https://www.unboundmedicine.com/medline/citation/19441290/Gold_nanoparticle_supported_silicon_plate_with_polymer_micelles_for_surface_assisted_laser_desorption/ionization_mass_spectrometry_of_peptides_ DB - PRIME DP - Unbound Medicine ER -