Tags

Type your tag names separated by a space and hit enter

Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life.
Ann Allergy Asthma Immunol. 2009 Apr; 102(4):323-7.AA

Abstract

BACKGROUND

Current asthma guidelines emphasize domains of impairment and risk for assessing severity and control, noting the need to consider separately the effects of asthma on asthma quality of life and functional capacity. Proper treatment to control asthma should result in improvements in patient well-being and functional status.

OBJECTIVE

To assess asthma-related quality of life after treatment with combination fluticasone propionate and salmeterol delivered via hydrofluoroalkane 134a metered-dose inhaler compared with the individual components alone.

METHODS

Asthma-related quality of life was assessed as part of two 12-week, randomized, double-blind, placebo-controlled clinical trials comparing the fluticasone propionate-salmeterol combination administered via a single metered-dose inhaler with salmeterol, fluticasone propionate, and placebo administered via traditional chlorofluorocarbon metered-dose inhaler. The Asthma Quality of Life Questionnaire was completed at baseline and end point. Score changes, overall and for the 4 separate domains, were compared within and among the treatment groups.

RESULTS

A total of 720 of 725 patients completed a baseline Asthma Quality of Life Questionnaire and were included in the analyses. In both studies, all mean scores improved significantly from baseline with the fluticasone propionate-salmeterol combination, with significantly greater improvement in the overall score compared with salmeterol alone, fluticasone propionate alone, and placebo groups. Improvements with the combination were also clinically meaningful compared with changes with salmeterol and placebo in both studies and with fluticasone propionate in study 1.

CONCLUSIONS

Treatment with combination fluticasone propionate and salmeterol delivered via hydrofluoroalkane metered-dose inhaler resulted in significantly greater improvements in asthma-related quality of life compared with individual components and placebo administered via traditional chlorofluorocarbon metered-dose inhaler.

Authors+Show Affiliations

GlaxoSmithKline, Research Triangle Park, North Carolina 27709-3398, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19441604

Citation

Edin, Heather M., et al. "Effects of Fluticasone Propionate and Salmeterol Hydrofluoroalkane Inhalation Aerosol On Asthma-related Quality of Life." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 102, no. 4, 2009, pp. 323-7.
Edin HM, Andersen LB, Schoaf L, et al. Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life. Ann Allergy Asthma Immunol. 2009;102(4):323-7.
Edin, H. M., Andersen, L. B., Schoaf, L., Scott-Wilson, C. A., Ho, S. Y., & Ortega, H. G. (2009). Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 102(4), 323-7. https://doi.org/10.1016/S1081-1206(10)60338-9
Edin HM, et al. Effects of Fluticasone Propionate and Salmeterol Hydrofluoroalkane Inhalation Aerosol On Asthma-related Quality of Life. Ann Allergy Asthma Immunol. 2009;102(4):323-7. PubMed PMID: 19441604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life. AU - Edin,Heather M, AU - Andersen,Leslie B, AU - Schoaf,Lynne, AU - Scott-Wilson,Catherine A, AU - Ho,Shu-Yen, AU - Ortega,Hector G, PY - 2009/5/16/entrez PY - 2009/5/16/pubmed PY - 2009/6/13/medline SP - 323 EP - 7 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 102 IS - 4 N2 - BACKGROUND: Current asthma guidelines emphasize domains of impairment and risk for assessing severity and control, noting the need to consider separately the effects of asthma on asthma quality of life and functional capacity. Proper treatment to control asthma should result in improvements in patient well-being and functional status. OBJECTIVE: To assess asthma-related quality of life after treatment with combination fluticasone propionate and salmeterol delivered via hydrofluoroalkane 134a metered-dose inhaler compared with the individual components alone. METHODS: Asthma-related quality of life was assessed as part of two 12-week, randomized, double-blind, placebo-controlled clinical trials comparing the fluticasone propionate-salmeterol combination administered via a single metered-dose inhaler with salmeterol, fluticasone propionate, and placebo administered via traditional chlorofluorocarbon metered-dose inhaler. The Asthma Quality of Life Questionnaire was completed at baseline and end point. Score changes, overall and for the 4 separate domains, were compared within and among the treatment groups. RESULTS: A total of 720 of 725 patients completed a baseline Asthma Quality of Life Questionnaire and were included in the analyses. In both studies, all mean scores improved significantly from baseline with the fluticasone propionate-salmeterol combination, with significantly greater improvement in the overall score compared with salmeterol alone, fluticasone propionate alone, and placebo groups. Improvements with the combination were also clinically meaningful compared with changes with salmeterol and placebo in both studies and with fluticasone propionate in study 1. CONCLUSIONS: Treatment with combination fluticasone propionate and salmeterol delivered via hydrofluoroalkane metered-dose inhaler resulted in significantly greater improvements in asthma-related quality of life compared with individual components and placebo administered via traditional chlorofluorocarbon metered-dose inhaler. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/19441604/Effects_of_fluticasone_propionate_and_salmeterol_hydrofluoroalkane_inhalation_aerosol_on_asthma_related_quality_of_life_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60338-9 DB - PRIME DP - Unbound Medicine ER -