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Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population.
Diabetes Res Clin Pract. 2009 Jun; 84(3):319-24.DR

Abstract

AIMS

To investigate alterations of insulin resistance (IR), chronic inflammation and urine albumin-to-creatinine ratio (ACR) in Chinese community-based prediabetic population.

MATERIALS AND METHODS

252 prediabetics [prediabetes (PD), including impaired fasting glucose (IFG), 91; impaired glucose tolerance (IGT), 123; IFG+IGT, 38] and 38 newly diagnosed-diabetics (NDDM) aged over 35 years older were screened from 2336 community individuals. 123 age and gender matched individuals with normal glucose tolerance (NGT) were selected as controls. Serum adiponectin, interleukin-6 (IL-6) levels and urine ACR were determined, HOMA-IR and Gutt's index were calculated to evaluate IR and insulin sensitivity, respectively.

RESULTS

The data displayed significant difference of serum adiponectin, IL-6, ACR and Gutt's index among PD, NDDM and NGT groups. Adiponectin level and Gutt's index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups (P<0.01). Unlike adiponectin and IL-6, ACR analysis indicates a gradual increase from NGT, IFG, IGT, IFG+IGT to NDDM individuals (P<0.01). Gutt's index showed significant difference between IFG and NDDM, IFG+IGT and NDDM (P<0.01), but HOMA-IR index did not.

CONCLUSIONS

IR, chronic inflammation and endothelial dysfunction dose exist in prediabetic individuals, especially in IFG+IGT population. Gutt's index and ACR might seem to be more sensitive than adiponectin and HOMA-IR index as IR and chronic inflammation maker in prediabetic population.

Authors+Show Affiliations

Department of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19442860

Citation

Lü, Qingguo, et al. "Community-based Population Data Indicates the Significant Alterations of Insulin Resistance, Chronic Inflammation and Urine ACR in IFG Combined IGT Group Among Prediabetic Population." Diabetes Research and Clinical Practice, vol. 84, no. 3, 2009, pp. 319-24.
Lü Q, Tong N, Liu Y, et al. Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population. Diabetes Res Clin Pract. 2009;84(3):319-24.
Lü, Q., Tong, N., Liu, Y., Li, N., Tang, X., Zhao, J., Cao, H., Li, D., Gou, L., Zhang, Y., Wan, J., & Jiang, L. (2009). Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population. Diabetes Research and Clinical Practice, 84(3), 319-24. https://doi.org/10.1016/j.diabres.2009.03.002
Lü Q, et al. Community-based Population Data Indicates the Significant Alterations of Insulin Resistance, Chronic Inflammation and Urine ACR in IFG Combined IGT Group Among Prediabetic Population. Diabetes Res Clin Pract. 2009;84(3):319-24. PubMed PMID: 19442860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population. AU - Lü,Qingguo, AU - Tong,Nanwei, AU - Liu,Yupu, AU - Li,Nali, AU - Tang,Xialian, AU - Zhao,Jianlin, AU - Cao,Hongyi, AU - Li,Daigang, AU - Gou,Lingli, AU - Zhang,Yuwei, AU - Wan,Jun, AU - Jiang,Li, PY - 2008/12/12/received PY - 2009/02/19/revised PY - 2009/03/02/accepted PY - 2009/5/16/entrez PY - 2009/5/16/pubmed PY - 2009/9/17/medline SP - 319 EP - 24 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 84 IS - 3 N2 - AIMS: To investigate alterations of insulin resistance (IR), chronic inflammation and urine albumin-to-creatinine ratio (ACR) in Chinese community-based prediabetic population. MATERIALS AND METHODS: 252 prediabetics [prediabetes (PD), including impaired fasting glucose (IFG), 91; impaired glucose tolerance (IGT), 123; IFG+IGT, 38] and 38 newly diagnosed-diabetics (NDDM) aged over 35 years older were screened from 2336 community individuals. 123 age and gender matched individuals with normal glucose tolerance (NGT) were selected as controls. Serum adiponectin, interleukin-6 (IL-6) levels and urine ACR were determined, HOMA-IR and Gutt's index were calculated to evaluate IR and insulin sensitivity, respectively. RESULTS: The data displayed significant difference of serum adiponectin, IL-6, ACR and Gutt's index among PD, NDDM and NGT groups. Adiponectin level and Gutt's index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups (P<0.01). Unlike adiponectin and IL-6, ACR analysis indicates a gradual increase from NGT, IFG, IGT, IFG+IGT to NDDM individuals (P<0.01). Gutt's index showed significant difference between IFG and NDDM, IFG+IGT and NDDM (P<0.01), but HOMA-IR index did not. CONCLUSIONS: IR, chronic inflammation and endothelial dysfunction dose exist in prediabetic individuals, especially in IFG+IGT population. Gutt's index and ACR might seem to be more sensitive than adiponectin and HOMA-IR index as IR and chronic inflammation maker in prediabetic population. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/19442860/Community_based_population_data_indicates_the_significant_alterations_of_insulin_resistance_chronic_inflammation_and_urine_ACR_in_IFG_combined_IGT_group_among_prediabetic_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(09)00115-6 DB - PRIME DP - Unbound Medicine ER -