Tags

Type your tag names separated by a space and hit enter

Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study.
Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4091-6.IO

Abstract

PURPOSE

To describe the relationship of retinal arteriolar and venular caliber with retinal nerve fiber layer (RNFL) thickness.

METHODS

A population-based, cross-sectional study of Malay persons aged 40 to 80 years residing in Singapore was conducted from 2004 to 2006. Retinal arteriolar and venular calibers were measured with a computer-based technique according to a validated, standardized protocol. RNFL was assessed with retinal tomography.

RESULTS

There were 2706 persons with gradable retinal photographs and HRT images of acceptable quality available for analysis. In linear regression models that adjusted for age, sex, diabetes, body mass index, intraocular pressure, and other factors, each standard deviation decrease in arteriolar and venular caliber was associated with a 5.81- and 8.37-microm decrease, respectively, in mean global RNFL thickness (both P < 0.001). These associations remained similar after persons with glaucoma were excluded. In persons with glaucoma, retinal venular caliber was independently associated with the temporal and temporal-to-inferior region of mean RNFL thickness in multivariate analysis; each SD decrease in retinal venular diameter was associated with an 8.54-microm decrease in the temporal region (P = 0.022), and a 38.32-microm decrease in the temporal-to-inferior region (P = 0.006) of mean RNFL thickness.

CONCLUSIONS

Narrower retinal vessel caliber was associated with reduced RNFL thickness in this Asian population.

Authors+Show Affiliations

Singapore Eye Research Institute, Singapore National Eye Center, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19443726

Citation

Zheng, Yingfeng, et al. "Relationship of Retinal Vascular Caliber With Retinal Nerve Fiber Layer Thickness: the Singapore Malay Eye Study." Investigative Ophthalmology & Visual Science, vol. 50, no. 9, 2009, pp. 4091-6.
Zheng Y, Cheung N, Aung T, et al. Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. Invest Ophthalmol Vis Sci. 2009;50(9):4091-6.
Zheng, Y., Cheung, N., Aung, T., Mitchell, P., He, M., & Wong, T. Y. (2009). Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. Investigative Ophthalmology & Visual Science, 50(9), 4091-6. https://doi.org/10.1167/iovs.09-3444
Zheng Y, et al. Relationship of Retinal Vascular Caliber With Retinal Nerve Fiber Layer Thickness: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2009;50(9):4091-6. PubMed PMID: 19443726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. AU - Zheng,Yingfeng, AU - Cheung,Ning, AU - Aung,Tin, AU - Mitchell,Paul, AU - He,Mingguang, AU - Wong,Tien Y, Y1 - 2009/05/14/ PY - 2009/5/16/entrez PY - 2009/5/16/pubmed PY - 2009/9/19/medline SP - 4091 EP - 6 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 50 IS - 9 N2 - PURPOSE: To describe the relationship of retinal arteriolar and venular caliber with retinal nerve fiber layer (RNFL) thickness. METHODS: A population-based, cross-sectional study of Malay persons aged 40 to 80 years residing in Singapore was conducted from 2004 to 2006. Retinal arteriolar and venular calibers were measured with a computer-based technique according to a validated, standardized protocol. RNFL was assessed with retinal tomography. RESULTS: There were 2706 persons with gradable retinal photographs and HRT images of acceptable quality available for analysis. In linear regression models that adjusted for age, sex, diabetes, body mass index, intraocular pressure, and other factors, each standard deviation decrease in arteriolar and venular caliber was associated with a 5.81- and 8.37-microm decrease, respectively, in mean global RNFL thickness (both P < 0.001). These associations remained similar after persons with glaucoma were excluded. In persons with glaucoma, retinal venular caliber was independently associated with the temporal and temporal-to-inferior region of mean RNFL thickness in multivariate analysis; each SD decrease in retinal venular diameter was associated with an 8.54-microm decrease in the temporal region (P = 0.022), and a 38.32-microm decrease in the temporal-to-inferior region (P = 0.006) of mean RNFL thickness. CONCLUSIONS: Narrower retinal vessel caliber was associated with reduced RNFL thickness in this Asian population. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/19443726/Relationship_of_retinal_vascular_caliber_with_retinal_nerve_fiber_layer_thickness:_the_singapore_malay_eye_study_ DB - PRIME DP - Unbound Medicine ER -