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Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats.
Pharmacol Rep 2009 Mar-Apr; 61(2):304-10PR

Abstract

Tobacco and cannabis are among the most widely abused drugs in humans, and recently, the functional interaction between nicotine and cannabinoids has been reported. The aim of the present studies is to evaluate the role of CB1 cannabinoid receptors in the reinstatement of nicotine-induced conditioned place preference. Nicotine-induced conditioned place preference was established (three-day nicotine sessions, 0.5 mg/kg), extinguished and reinstated by a priming dose of nicotine. It was shown that the CB1 receptor antagonist AM 251 (0.25 and 0.5 mg/kg) in a dose-dependent manner attenuates the reinstatement of nicotine place conditioning. These studies suggest a role for CB1 cannabinoids receptors in preventing the reinstatement of nicotine addiction.

Authors+Show Affiliations

Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Staszica 4, PL 20-081 Lublin, Poland. basia.budzynska@am.lublin.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19443943

Citation

Budzyńska, Barbara, et al. "Effects of the Cannabinoid CB1 Receptor Antagonist AM 251 On the Reinstatement of Nicotine-conditioned Place Preference By Drug Priming in Rats." Pharmacological Reports : PR, vol. 61, no. 2, 2009, pp. 304-10.
Budzyńska B, Kruk M, Biała G. Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Pharmacol Rep. 2009;61(2):304-10.
Budzyńska, B., Kruk, M., & Biała, G. (2009). Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Pharmacological Reports : PR, 61(2), pp. 304-10.
Budzyńska B, Kruk M, Biała G. Effects of the Cannabinoid CB1 Receptor Antagonist AM 251 On the Reinstatement of Nicotine-conditioned Place Preference By Drug Priming in Rats. Pharmacol Rep. 2009;61(2):304-10. PubMed PMID: 19443943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats. AU - Budzyńska,Barbara, AU - Kruk,Marta, AU - Biała,Grazyna, PY - 2008/09/09/received PY - 2009/02/20/revised PY - 2009/5/16/entrez PY - 2009/5/16/pubmed PY - 2009/7/15/medline SP - 304 EP - 10 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 61 IS - 2 N2 - Tobacco and cannabis are among the most widely abused drugs in humans, and recently, the functional interaction between nicotine and cannabinoids has been reported. The aim of the present studies is to evaluate the role of CB1 cannabinoid receptors in the reinstatement of nicotine-induced conditioned place preference. Nicotine-induced conditioned place preference was established (three-day nicotine sessions, 0.5 mg/kg), extinguished and reinstated by a priming dose of nicotine. It was shown that the CB1 receptor antagonist AM 251 (0.25 and 0.5 mg/kg) in a dose-dependent manner attenuates the reinstatement of nicotine place conditioning. These studies suggest a role for CB1 cannabinoids receptors in preventing the reinstatement of nicotine addiction. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/19443943/abstract/Effects_of_the_cannabinoid_CB1_receptor_antagonist_AM_251_on_the_reinstatement_of_nicotine_conditioned_place_preference_by_drug_priming_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(09)70036-2 DB - PRIME DP - Unbound Medicine ER -