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Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage.
Food Chem Toxicol. 2009 Aug; 47(8):1914-20.FC

Abstract

Isorhamnetin 3-O-beta-D-glucopyranoside (1) was isolated from Salicornia herbacea. The inhibitory effects of compound 1 on oxidative stress were evaluated in free-cellular and cellular systems. An increased concentration of compound 1 not only exhibited dose-dependent scavenging activities on the generation of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and carbon-centered radicals, but also significantly decreased levels of intracellular reactive oxygen species (ROS) in a dose-dependent manner. Further, antioxidative mechanisms by compound 1 were examined by measuring the intracellular glutathione (GSH) level and expression levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione reductase and heme oxygenase-1 (HO-1). Compound 1 significantly elevated GSH level as well as expression levels of antioxidant enzymes which were closely related with amount of cellular ROS. In addition, it significantly inhibited oxidative damage of purified genomic DNA and suppressed activity of myeloperoxidase (MPO), a generator of potent oxidant (hypochlorous acid), in tumor necrosis factor-alpha (TNF-alpha) stimulated human myeloid cells. Therefore, these results suggested that compound 1 has a therapeutic effectiveness in prevention of ROS-induced cellular damage and is a candidate worthy of being developed as a potential natural antioxidant related to oxidative stress.

Authors+Show Affiliations

Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19445998

Citation

Kong, Chang-Suk, et al. "Protective Effect of Isorhamnetin 3-O-beta-D-glucopyranoside From Salicornia Herbacea Against Oxidation-induced Cell Damage." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 8, 2009, pp. 1914-20.
Kong CS, Kim JA, Qian ZJ, et al. Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage. Food Chem Toxicol. 2009;47(8):1914-20.
Kong, C. S., Kim, J. A., Qian, Z. J., Kim, Y. A., Lee, J. I., Kim, S. K., Nam, T. J., & Seo, Y. (2009). Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(8), 1914-20. https://doi.org/10.1016/j.fct.2009.05.002
Kong CS, et al. Protective Effect of Isorhamnetin 3-O-beta-D-glucopyranoside From Salicornia Herbacea Against Oxidation-induced Cell Damage. Food Chem Toxicol. 2009;47(8):1914-20. PubMed PMID: 19445998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage. AU - Kong,Chang-Suk, AU - Kim,Jung-Ae, AU - Qian,Zhong-Ji, AU - Kim,You Ah, AU - Lee,Jung Im, AU - Kim,Se-Kwon, AU - Nam,Taek Jeong, AU - Seo,Youngwan, Y1 - 2009/05/13/ PY - 2009/03/30/received PY - 2009/04/25/revised PY - 2009/05/07/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2009/10/20/medline SP - 1914 EP - 20 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 8 N2 - Isorhamnetin 3-O-beta-D-glucopyranoside (1) was isolated from Salicornia herbacea. The inhibitory effects of compound 1 on oxidative stress were evaluated in free-cellular and cellular systems. An increased concentration of compound 1 not only exhibited dose-dependent scavenging activities on the generation of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and carbon-centered radicals, but also significantly decreased levels of intracellular reactive oxygen species (ROS) in a dose-dependent manner. Further, antioxidative mechanisms by compound 1 were examined by measuring the intracellular glutathione (GSH) level and expression levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione reductase and heme oxygenase-1 (HO-1). Compound 1 significantly elevated GSH level as well as expression levels of antioxidant enzymes which were closely related with amount of cellular ROS. In addition, it significantly inhibited oxidative damage of purified genomic DNA and suppressed activity of myeloperoxidase (MPO), a generator of potent oxidant (hypochlorous acid), in tumor necrosis factor-alpha (TNF-alpha) stimulated human myeloid cells. Therefore, these results suggested that compound 1 has a therapeutic effectiveness in prevention of ROS-induced cellular damage and is a candidate worthy of being developed as a potential natural antioxidant related to oxidative stress. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19445998/Protective_effect_of_isorhamnetin_3_O_beta_D_glucopyranoside_from_Salicornia_herbacea_against_oxidation_induced_cell_damage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00219-1 DB - PRIME DP - Unbound Medicine ER -