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Impact of different metabolic syndrome classifications on the metabolic syndrome prevalence in a young Middle Eastern population.
Metabolism. 2009 Jun; 58(6):746-52.M

Abstract

The metabolic syndrome (MetS) prevalence in a young Middle Eastern population has never been studied. We studied this prevalence in a randomly selected population of Lebanese students using different MetS classifications. Three hundred eighty-one subjects aged 18 to 30 years were included in the study. Anthropometric and biological parameters (waist circumference [WC], systolic and diastolic blood pressures, fasting plasma glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and homeostasis model assessment [HOMA] index to assess insulin resistance) were measured. Receiver operating characteristic (ROC) curves were generated to determine population-specific cutoff values for MetS parameters and HOMA index. The MetS prevalence was calculated using the National Cholesterol Education Program's Adult Treatment Panel III (ATP-III), the actualized ATP-III, and our cutoffs, either with or without HOMA index as an extra risk factor. The MetS prevalence using the ATP-III and the actualized ATP-III was, respectively, 5.25% and 5.28%. It increased to 9.19% when using our cutoff values and to 12.64% when HOMA index was added. This increase was significant only in men. The identified cutoff values are, for WC, 91 cm in women and 99.5 cm in men and, for HOMA index, 2.32. Among the MetS components, WC was the best MetS predictor, whereas fasting plasma glucose was the poorest. Our study shows that the MetS prevalence in Lebanon is comparable with other countries. In addition, we identified in our population new cutoff points for MetS parameters and HOMA index that allow the detection of a higher number of subjects with the MetS, mainly in the male population.

Authors+Show Affiliations

Department of Biochemistry, Saint-Joseph University, P.B. 11-5076 Riad El Solh, Beirut 1107 2180, Lebanon. rima.chedid@usj.edu.lbNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19446111

Citation

Chedid, Rima, et al. "Impact of Different Metabolic Syndrome Classifications On the Metabolic Syndrome Prevalence in a Young Middle Eastern Population." Metabolism: Clinical and Experimental, vol. 58, no. 6, 2009, pp. 746-52.
Chedid R, Gannagé-Yared MH, Khalifé S, et al. Impact of different metabolic syndrome classifications on the metabolic syndrome prevalence in a young Middle Eastern population. Metabolism. 2009;58(6):746-52.
Chedid, R., Gannagé-Yared, M. H., Khalifé, S., Halaby, G., & Zoghbi, F. (2009). Impact of different metabolic syndrome classifications on the metabolic syndrome prevalence in a young Middle Eastern population. Metabolism: Clinical and Experimental, 58(6), 746-52. https://doi.org/10.1016/j.metabol.2008.11.014
Chedid R, et al. Impact of Different Metabolic Syndrome Classifications On the Metabolic Syndrome Prevalence in a Young Middle Eastern Population. Metabolism. 2009;58(6):746-52. PubMed PMID: 19446111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of different metabolic syndrome classifications on the metabolic syndrome prevalence in a young Middle Eastern population. AU - Chedid,Rima, AU - Gannagé-Yared,Marie-Hélène, AU - Khalifé,Simon, AU - Halaby,Georges, AU - Zoghbi,Fernand, PY - 2008/09/09/received PY - 2008/11/21/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2009/6/11/medline SP - 746 EP - 52 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 6 N2 - The metabolic syndrome (MetS) prevalence in a young Middle Eastern population has never been studied. We studied this prevalence in a randomly selected population of Lebanese students using different MetS classifications. Three hundred eighty-one subjects aged 18 to 30 years were included in the study. Anthropometric and biological parameters (waist circumference [WC], systolic and diastolic blood pressures, fasting plasma glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and homeostasis model assessment [HOMA] index to assess insulin resistance) were measured. Receiver operating characteristic (ROC) curves were generated to determine population-specific cutoff values for MetS parameters and HOMA index. The MetS prevalence was calculated using the National Cholesterol Education Program's Adult Treatment Panel III (ATP-III), the actualized ATP-III, and our cutoffs, either with or without HOMA index as an extra risk factor. The MetS prevalence using the ATP-III and the actualized ATP-III was, respectively, 5.25% and 5.28%. It increased to 9.19% when using our cutoff values and to 12.64% when HOMA index was added. This increase was significant only in men. The identified cutoff values are, for WC, 91 cm in women and 99.5 cm in men and, for HOMA index, 2.32. Among the MetS components, WC was the best MetS predictor, whereas fasting plasma glucose was the poorest. Our study shows that the MetS prevalence in Lebanon is comparable with other countries. In addition, we identified in our population new cutoff points for MetS parameters and HOMA index that allow the detection of a higher number of subjects with the MetS, mainly in the male population. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19446111/Impact_of_different_metabolic_syndrome_classifications_on_the_metabolic_syndrome_prevalence_in_a_young_Middle_Eastern_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00432-0 DB - PRIME DP - Unbound Medicine ER -