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Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production.
J Biotechnol. 2009 Oct 12; 144(1):23-30.JB

Abstract

Yeast strains of Saccharomyces cerevisiae have been extensively studied in recent years for fuel ethanol production, in which yeast cells are exposed to various stresses such as high temperature, ethanol inhibition, and osmotic pressure from product and substrate sugars as well as the inhibitory substances released from the pretreatment of lignocellulosic biomass. An in-depth understanding of the mechanism of yeast stress tolerance contributes to breeding more robust strains for ethanol production, especially under very high gravity conditions. Taking advantage of the "omics" technology, the stress response and defense mechanism of yeast cells during ethanol fermentation were further explored, and the newly emerged tools such as genome shuffling and global transcription machinery engineering have been applied to breed stress resistant yeast strains for ethanol production. In this review, the latest development of stress tolerance mechanisms was focused, and improvement of yeast stress tolerance by both random and rational tools was presented.

Authors+Show Affiliations

Department of Bioscience and Bioengineering, Dalian University of Technology, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19446584

Citation

Zhao, X Q., and F W. Bai. "Mechanisms of Yeast Stress Tolerance and Its Manipulation for Efficient Fuel Ethanol Production." Journal of Biotechnology, vol. 144, no. 1, 2009, pp. 23-30.
Zhao XQ, Bai FW. Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production. J Biotechnol. 2009;144(1):23-30.
Zhao, X. Q., & Bai, F. W. (2009). Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production. Journal of Biotechnology, 144(1), 23-30. https://doi.org/10.1016/j.jbiotec.2009.05.001
Zhao XQ, Bai FW. Mechanisms of Yeast Stress Tolerance and Its Manipulation for Efficient Fuel Ethanol Production. J Biotechnol. 2009 Oct 12;144(1):23-30. PubMed PMID: 19446584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production. AU - Zhao,X Q, AU - Bai,F W, Y1 - 2009/05/14/ PY - 2009/01/30/received PY - 2009/04/28/revised PY - 2009/05/06/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2010/2/17/medline SP - 23 EP - 30 JF - Journal of biotechnology JO - J Biotechnol VL - 144 IS - 1 N2 - Yeast strains of Saccharomyces cerevisiae have been extensively studied in recent years for fuel ethanol production, in which yeast cells are exposed to various stresses such as high temperature, ethanol inhibition, and osmotic pressure from product and substrate sugars as well as the inhibitory substances released from the pretreatment of lignocellulosic biomass. An in-depth understanding of the mechanism of yeast stress tolerance contributes to breeding more robust strains for ethanol production, especially under very high gravity conditions. Taking advantage of the "omics" technology, the stress response and defense mechanism of yeast cells during ethanol fermentation were further explored, and the newly emerged tools such as genome shuffling and global transcription machinery engineering have been applied to breed stress resistant yeast strains for ethanol production. In this review, the latest development of stress tolerance mechanisms was focused, and improvement of yeast stress tolerance by both random and rational tools was presented. SN - 1873-4863 UR - https://www.unboundmedicine.com/medline/citation/19446584/Mechanisms_of_yeast_stress_tolerance_and_its_manipulation_for_efficient_fuel_ethanol_production_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1656(09)00205-3 DB - PRIME DP - Unbound Medicine ER -