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An economic analysis of rotavirus vaccination in Italy.
Vaccine. 2009 Jun 12; 27(29):3904-11.V

Abstract

We have evaluated health and economic benefits of a universal infant vaccination with two rotavirus vaccines registered in Italy, on the bases of the burden of rotavirus gastroenteritis (RVGE) in a birth cohort of 520,000 Italian infants followed until 5 years of age. Estimates from published and unpublished sources of disease burden, costs, vaccine coverage, efficacy trials of both vaccines, and price were used to estimate cost-effectiveness from the perspectives of the Italian National Health Service (NHS) and society. According to our estimates, a universal rotavirus vaccination program would avoid 10,679 hospitalizations, 39,202 emergency visits, and 44,223 at home visits. At 65.6 euro per vaccination courses, the program would cost 30,700,800 euro and realize a net loss of 9,057,928 euro from the Italian NHS perspective. On the contrary, the program would provide a net savings of 24,324,198 euro from the societal perspective. From the Italian NHS perspective, the break-even price per vaccination course should be reduced at least to 46.25 euro to achieve a zero cost-effectiveness ratio.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Giammanco MD
Dipartimento di Analisi dei Processi Politici Sociali ed Istituzionali, University of Catania, I-95131 Catania, Italy.
Coniglio MA
No affiliation info available
Pignato S
No affiliation info available
Giammanco G
No affiliation info available

MeSH

AnimalsChild, PreschoolCost of IllnessCost-Benefit AnalysisGastroenteritisHumansIncidenceInfantItalyRotavirus InfectionsRotavirus VaccinesVaccination

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19446934

Citation

Giammanco, Maria Daniela, et al. "An Economic Analysis of Rotavirus Vaccination in Italy." Vaccine, vol. 27, no. 29, 2009, pp. 3904-11.
Giammanco MD, Coniglio MA, Pignato S, et al. An economic analysis of rotavirus vaccination in Italy. Vaccine. 2009;27(29):3904-11.
Giammanco, M. D., Coniglio, M. A., Pignato, S., & Giammanco, G. (2009). An economic analysis of rotavirus vaccination in Italy. Vaccine, 27(29), 3904-11. https://doi.org/10.1016/j.vaccine.2009.04.002
Giammanco MD, et al. An Economic Analysis of Rotavirus Vaccination in Italy. Vaccine. 2009 Jun 12;27(29):3904-11. PubMed PMID: 19446934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An economic analysis of rotavirus vaccination in Italy. AU - Giammanco,Maria Daniela, AU - Coniglio,Maria Anna, AU - Pignato,Sarina, AU - Giammanco,Giuseppe, Y1 - 2009/04/24/ PY - 2008/11/28/received PY - 2009/03/31/revised PY - 2009/04/02/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2009/9/1/medline SP - 3904 EP - 11 JF - Vaccine JO - Vaccine VL - 27 IS - 29 N2 - We have evaluated health and economic benefits of a universal infant vaccination with two rotavirus vaccines registered in Italy, on the bases of the burden of rotavirus gastroenteritis (RVGE) in a birth cohort of 520,000 Italian infants followed until 5 years of age. Estimates from published and unpublished sources of disease burden, costs, vaccine coverage, efficacy trials of both vaccines, and price were used to estimate cost-effectiveness from the perspectives of the Italian National Health Service (NHS) and society. According to our estimates, a universal rotavirus vaccination program would avoid 10,679 hospitalizations, 39,202 emergency visits, and 44,223 at home visits. At 65.6 euro per vaccination courses, the program would cost 30,700,800 euro and realize a net loss of 9,057,928 euro from the Italian NHS perspective. On the contrary, the program would provide a net savings of 24,324,198 euro from the societal perspective. From the Italian NHS perspective, the break-even price per vaccination course should be reduced at least to 46.25 euro to achieve a zero cost-effectiveness ratio. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/19446934/An_economic_analysis_of_rotavirus_vaccination_in_Italy_ DB - PRIME DP - Unbound Medicine ER -