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Muscimol state-dependent memory: involvement of dorsal hippocampal mu-opioid receptors.
Behav Brain Res. 2009 Aug 24; 202(1):5-10.BB

Abstract

In the present study, the effects of subcutaneous (s.c.) injections of morphine, a mu-opioid receptor agonist and intra-dorsal hippocampal (intra-CA1) injections of naloxone, a mu-opioid receptor antagonist on muscimol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-CA1 administration of a GABAA receptor agonist, muscimol (0.025, 0.05, 0.1 and 0.2 microg/mouse) dose dependently induced impairment of memory retention. Pre-test injection of muscimol (0.05, 0.1 and 0.2 microg/mouse, intra-CA1) induced state-dependent retrieval of the memory acquired under pre-training muscimol (0.1 microg/mouse, intra-CA1) influence. Pre-test injection of morphine (0.5 and 1 mg/kg, s.c.) 30 min before the administration of muscimol (0.1 microg/mouse, intra-CA1) dose dependently inhibited muscimol state-dependent memory. Pre-test intra-CA1 injection of naloxone (0.1 and 0.2 microg/mouse, intra-CA1) improved pre-training muscimol (0.1 microg/mouse)-induced retrieval impairment. Moreover, pre-test administration of naloxone (0.1 and 0.2 microg/mouse, intra-CA1) with an ineffective dose of muscimol (0.025 microg/mouse) significantly restored the retrieval and induced muscimol state-dependent memory. These findings implicate the involvement of a dorsal hippocampal mu-opioid receptor mechanism in muscimol state-dependent memory.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. jafarisa@sina.tums.ac.irNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19447274

Citation

Jafari-Sabet, Majid, and Iman Jannat-Dastjerdi. "Muscimol State-dependent Memory: Involvement of Dorsal Hippocampal Mu-opioid Receptors." Behavioural Brain Research, vol. 202, no. 1, 2009, pp. 5-10.
Jafari-Sabet M, Jannat-Dastjerdi I. Muscimol state-dependent memory: involvement of dorsal hippocampal mu-opioid receptors. Behav Brain Res. 2009;202(1):5-10.
Jafari-Sabet, M., & Jannat-Dastjerdi, I. (2009). Muscimol state-dependent memory: involvement of dorsal hippocampal mu-opioid receptors. Behavioural Brain Research, 202(1), 5-10. https://doi.org/10.1016/j.bbr.2009.03.010
Jafari-Sabet M, Jannat-Dastjerdi I. Muscimol State-dependent Memory: Involvement of Dorsal Hippocampal Mu-opioid Receptors. Behav Brain Res. 2009 Aug 24;202(1):5-10. PubMed PMID: 19447274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscimol state-dependent memory: involvement of dorsal hippocampal mu-opioid receptors. AU - Jafari-Sabet,Majid, AU - Jannat-Dastjerdi,Iman, Y1 - 2009/03/19/ PY - 2009/01/17/received PY - 2009/02/26/revised PY - 2009/03/06/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2009/8/20/medline SP - 5 EP - 10 JF - Behavioural brain research JO - Behav Brain Res VL - 202 IS - 1 N2 - In the present study, the effects of subcutaneous (s.c.) injections of morphine, a mu-opioid receptor agonist and intra-dorsal hippocampal (intra-CA1) injections of naloxone, a mu-opioid receptor antagonist on muscimol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-CA1 administration of a GABAA receptor agonist, muscimol (0.025, 0.05, 0.1 and 0.2 microg/mouse) dose dependently induced impairment of memory retention. Pre-test injection of muscimol (0.05, 0.1 and 0.2 microg/mouse, intra-CA1) induced state-dependent retrieval of the memory acquired under pre-training muscimol (0.1 microg/mouse, intra-CA1) influence. Pre-test injection of morphine (0.5 and 1 mg/kg, s.c.) 30 min before the administration of muscimol (0.1 microg/mouse, intra-CA1) dose dependently inhibited muscimol state-dependent memory. Pre-test intra-CA1 injection of naloxone (0.1 and 0.2 microg/mouse, intra-CA1) improved pre-training muscimol (0.1 microg/mouse)-induced retrieval impairment. Moreover, pre-test administration of naloxone (0.1 and 0.2 microg/mouse, intra-CA1) with an ineffective dose of muscimol (0.025 microg/mouse) significantly restored the retrieval and induced muscimol state-dependent memory. These findings implicate the involvement of a dorsal hippocampal mu-opioid receptor mechanism in muscimol state-dependent memory. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19447274/Muscimol_state_dependent_memory:_involvement_of_dorsal_hippocampal_mu_opioid_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00156-9 DB - PRIME DP - Unbound Medicine ER -