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N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model.
Neurosci Res. 2009 Jul; 64(3):267-72.NR

Abstract

The aim of this study was to determine the influence of N-(anilinomethyl)-p-isopropoxyphenylsuccinimide (AMIPPS) on the protective action of carbamazepine, phenobarbital, phenytoin, and valproate in the mouse maximal electroshock seizure model. Results indicate that AMIPPS administered separately (i.p., at doses of 75 and 150 mg/kg), significantly elevated the threshold for electroconvulsions in mice. Moreover, AMIPPS (37.5mg/kg) significantly enhanced the anticonvulsant activity of phenobarbital and valproate, but not that of carbamazepine or phenytoin in the maximal electroshock seizure test in mice. AMIPPS (18.75 mg/kg) had no impact on the antiseizure action of phenobarbital and valproate against maximal electroshock seizure-induced seizures in mice. Pharmacokinetic experiments revealed that AMIPPS significantly increased total brain valproate concentrations and it had no impact on total brain concentrations of phenobarbital in mice. In conclusion, the enhanced antielectroshock action of phenobarbital by AMIPPS and lack of pharmacokinetic interaction make the combination of AMIPPS with phenobarbital of pivotal importance for further experimental and clinical studies. Although AMIPPS potentiated the anticonvulsant action of valproate in the maximal electroshock seizure test, the caution is advised when combining these drugs due to the risk of pharmacokinetic interactions. The combinations of AMIPPS with carbamazepine and phenytoin are neutral from a preclinical viewpoint.

Authors+Show Affiliations

Department of Pathophysiology, Medical University of Lublin, Lublin, Poland. jluszczki@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19447295

Citation

Luszczki, Jarogniew J., et al. "N-(anilinomethyl)-p-isopropoxyphenylsuccinimide Potentiates the Anticonvulsant Action of Phenobarbital and Valproate in the Mouse Maximal Electroshock-induced Seizure Model." Neuroscience Research, vol. 64, no. 3, 2009, pp. 267-72.
Luszczki JJ, Kocharov SL, Czuczwar SJ. N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model. Neurosci Res. 2009;64(3):267-72.
Luszczki, J. J., Kocharov, S. L., & Czuczwar, S. J. (2009). N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model. Neuroscience Research, 64(3), 267-72. https://doi.org/10.1016/j.neures.2009.03.010
Luszczki JJ, Kocharov SL, Czuczwar SJ. N-(anilinomethyl)-p-isopropoxyphenylsuccinimide Potentiates the Anticonvulsant Action of Phenobarbital and Valproate in the Mouse Maximal Electroshock-induced Seizure Model. Neurosci Res. 2009;64(3):267-72. PubMed PMID: 19447295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model. AU - Luszczki,Jarogniew J, AU - Kocharov,Sergey L, AU - Czuczwar,Stanislaw J, Y1 - 2009/03/31/ PY - 2009/02/10/received PY - 2009/03/19/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2009/8/21/medline SP - 267 EP - 72 JF - Neuroscience research JO - Neurosci Res VL - 64 IS - 3 N2 - The aim of this study was to determine the influence of N-(anilinomethyl)-p-isopropoxyphenylsuccinimide (AMIPPS) on the protective action of carbamazepine, phenobarbital, phenytoin, and valproate in the mouse maximal electroshock seizure model. Results indicate that AMIPPS administered separately (i.p., at doses of 75 and 150 mg/kg), significantly elevated the threshold for electroconvulsions in mice. Moreover, AMIPPS (37.5mg/kg) significantly enhanced the anticonvulsant activity of phenobarbital and valproate, but not that of carbamazepine or phenytoin in the maximal electroshock seizure test in mice. AMIPPS (18.75 mg/kg) had no impact on the antiseizure action of phenobarbital and valproate against maximal electroshock seizure-induced seizures in mice. Pharmacokinetic experiments revealed that AMIPPS significantly increased total brain valproate concentrations and it had no impact on total brain concentrations of phenobarbital in mice. In conclusion, the enhanced antielectroshock action of phenobarbital by AMIPPS and lack of pharmacokinetic interaction make the combination of AMIPPS with phenobarbital of pivotal importance for further experimental and clinical studies. Although AMIPPS potentiated the anticonvulsant action of valproate in the maximal electroshock seizure test, the caution is advised when combining these drugs due to the risk of pharmacokinetic interactions. The combinations of AMIPPS with carbamazepine and phenytoin are neutral from a preclinical viewpoint. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/19447295/N__anilinomethyl__p_isopropoxyphenylsuccinimide_potentiates_the_anticonvulsant_action_of_phenobarbital_and_valproate_in_the_mouse_maximal_electroshock_induced_seizure_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(09)00090-X DB - PRIME DP - Unbound Medicine ER -