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Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons.
Neurosci Res. 2009 Jul; 64(3):306-10.NR

Abstract

We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the protective role of GSRd to attenuate ischemic neuronal injury in vitro. Cultured hippocampal neurons were exposed to oxygen-glucose deprivation (OGD) for 2h followed by a 24-h reoxygenation. GSRd exhibited remarkable neuroprotection when presented during OGD and reoxygenation, which may be ascribed to its antioxidative properties by reducing the intracellular reactive oxygen species and malondialdehyde production; increasing glutathione content; and enhancing the antioxidant enzymatic activities of catalase, superoxide dismutase and glutathione peroxidase. Additionally, GSRd could stabilize the mitochondrial membrane potential and attenuate apoptotic death of hippocampal neurons after OGD exposure. These findings suggested that GSRd may be a potential neuroprotective agent for cerebral ischemic injury and should encourage further in vivo studies on stroke to explore the potential neuroprotective efficacy of GSRd.

Authors+Show Affiliations

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19447300

Citation

Ye, Ruidong, et al. "Neuroprotective Effects of Ginsenoside Rd Against Oxygen-glucose Deprivation in Cultured Hippocampal Neurons." Neuroscience Research, vol. 64, no. 3, 2009, pp. 306-10.
Ye R, Li N, Han J, et al. Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons. Neurosci Res. 2009;64(3):306-10.
Ye, R., Li, N., Han, J., Kong, X., Cao, R., Rao, Z., & Zhao, G. (2009). Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons. Neuroscience Research, 64(3), 306-10. https://doi.org/10.1016/j.neures.2009.03.016
Ye R, et al. Neuroprotective Effects of Ginsenoside Rd Against Oxygen-glucose Deprivation in Cultured Hippocampal Neurons. Neurosci Res. 2009;64(3):306-10. PubMed PMID: 19447300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons. AU - Ye,Ruidong, AU - Li,Nanlin, AU - Han,Junliang, AU - Kong,Xiangwei, AU - Cao,Rong, AU - Rao,Zhiren, AU - Zhao,Gang, Y1 - 2009/04/10/ PY - 2008/12/31/received PY - 2009/03/26/revised PY - 2009/03/31/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2009/8/21/medline SP - 306 EP - 10 JF - Neuroscience research JO - Neurosci. Res. VL - 64 IS - 3 N2 - We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the protective role of GSRd to attenuate ischemic neuronal injury in vitro. Cultured hippocampal neurons were exposed to oxygen-glucose deprivation (OGD) for 2h followed by a 24-h reoxygenation. GSRd exhibited remarkable neuroprotection when presented during OGD and reoxygenation, which may be ascribed to its antioxidative properties by reducing the intracellular reactive oxygen species and malondialdehyde production; increasing glutathione content; and enhancing the antioxidant enzymatic activities of catalase, superoxide dismutase and glutathione peroxidase. Additionally, GSRd could stabilize the mitochondrial membrane potential and attenuate apoptotic death of hippocampal neurons after OGD exposure. These findings suggested that GSRd may be a potential neuroprotective agent for cerebral ischemic injury and should encourage further in vivo studies on stroke to explore the potential neuroprotective efficacy of GSRd. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/19447300/Neuroprotective_effects_of_ginsenoside_Rd_against_oxygen_glucose_deprivation_in_cultured_hippocampal_neurons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(09)00095-9 DB - PRIME DP - Unbound Medicine ER -