Tags

Type your tag names separated by a space and hit enter

Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men.
J Urol 2009; 182(1):237-48JU

Abstract

PURPOSE

We determined the efficacy of coenzyme Q10 supplementation on semen parameters, sperm function and reproductive hormone profiles in infertile men.

MATERIALS AND METHODS

A total of 212 infertile men with idiopathic oligoasthenoteratospermia were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase. Two semen analyses, acrosome reaction test, immunobead test for antisperm antibody, and determination of resting levels of luteinizing hormone, follicle-stimulating hormone, prolactin, testosterone and inhibin B were done in all participants. Blood and seminal plasma total coenzyme Q10 was also assessed.

RESULTS

Significant improvement in sperm density and motility was evident with coenzyme Q10 therapy (each p = 0.01). Using the Kruger classification sperm morphology evaluation revealed an increase in the percent of normal forms in the coenzyme Q10 group (p = 0.07). A positive correlation was found between treatment duration with coenzyme Q10 and sperm count (r = 0.46, p = 0.03) as well as with sperm motility (r = 0.45, p = 0.04) and sperm morphology (r = 0.34, p = 0.04). The coenzyme Q10 group had a significant decrease in serum follicle-stimulating hormone and luteinizing hormone at the 26-week treatment phase (each p = 0.03). By the end of the treatment phase the mean +/- SD acrosome reaction had increased from 14% +/- 8% and 15% +/- 8% to 31% +/- 11% and 16% +/- 10% in the coenzyme Q10 and placebo groups, respectively (p = 0.01).

CONCLUSIONS

Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters. However, further studies are needed to draw a final conclusion and evaluate the effect of coenzyme Q10 supplementation on the pregnancy rate.

Authors+Show Affiliations

Urology and Nephrology Research Center, Shahid Beheshti University, Tehran, Iran. safarinejad@unrc.ir

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19447425

Citation

Safarinejad, Mohammad Reza. "Efficacy of Coenzyme Q10 On Semen Parameters, Sperm Function and Reproductive Hormones in Infertile Men." The Journal of Urology, vol. 182, no. 1, 2009, pp. 237-48.
Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol. 2009;182(1):237-48.
Safarinejad, M. R. (2009). Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of Urology, 182(1), pp. 237-48. doi:10.1016/j.juro.2009.02.121.
Safarinejad MR. Efficacy of Coenzyme Q10 On Semen Parameters, Sperm Function and Reproductive Hormones in Infertile Men. J Urol. 2009;182(1):237-48. PubMed PMID: 19447425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. A1 - Safarinejad,Mohammad Reza, Y1 - 2009/05/17/ PY - 2008/11/05/received PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2010/7/2/medline SP - 237 EP - 48 JF - The Journal of urology JO - J. Urol. VL - 182 IS - 1 N2 - PURPOSE: We determined the efficacy of coenzyme Q10 supplementation on semen parameters, sperm function and reproductive hormone profiles in infertile men. MATERIALS AND METHODS: A total of 212 infertile men with idiopathic oligoasthenoteratospermia were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase. Two semen analyses, acrosome reaction test, immunobead test for antisperm antibody, and determination of resting levels of luteinizing hormone, follicle-stimulating hormone, prolactin, testosterone and inhibin B were done in all participants. Blood and seminal plasma total coenzyme Q10 was also assessed. RESULTS: Significant improvement in sperm density and motility was evident with coenzyme Q10 therapy (each p = 0.01). Using the Kruger classification sperm morphology evaluation revealed an increase in the percent of normal forms in the coenzyme Q10 group (p = 0.07). A positive correlation was found between treatment duration with coenzyme Q10 and sperm count (r = 0.46, p = 0.03) as well as with sperm motility (r = 0.45, p = 0.04) and sperm morphology (r = 0.34, p = 0.04). The coenzyme Q10 group had a significant decrease in serum follicle-stimulating hormone and luteinizing hormone at the 26-week treatment phase (each p = 0.03). By the end of the treatment phase the mean +/- SD acrosome reaction had increased from 14% +/- 8% and 15% +/- 8% to 31% +/- 11% and 16% +/- 10% in the coenzyme Q10 and placebo groups, respectively (p = 0.01). CONCLUSIONS: Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters. However, further studies are needed to draw a final conclusion and evaluate the effect of coenzyme Q10 supplementation on the pregnancy rate. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/19447425/Efficacy_of_coenzyme_Q10_on_semen_parameters_sperm_function_and_reproductive_hormones_in_infertile_men_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2009.02.121?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -