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Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum).
Exp Toxicol Pathol. 2010 May; 62(3):227-33.ET

Abstract

This study sought to characterize the distribution of phenols and antioxidant activities in hot short pepper (Capsicum frutescens var. abbreviatum) and their inhibition of cyclophosphamide-induced oxidative stress in rat's brain. The total phenol content and antioxidant activities of pepper flesh (pericarp) and seeds were determined in vitro and in vivo. The results of the study revealed that intraperitoneal administration of cyclophosphamide (75mg/kg of body weight) caused a significant increase (P<0.05) in the malondialdehyde (MDA) content of the brain; however, there was a significant decrease (P<0.05) in the brain MDA content, in those of rats fed diet containing pepper; the flesh showed a higher inhibitory effect. In addition, dietary inclusion of the pepper (seed and flesh) also caused a dose-dependent inhibition of serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase and total bilirubin; likewise, dietary inclusion of the flesh inhibited MDA production than the seeds. The higher inhibition of oxidative stress in brain and serum enzymes and metabolites by the flesh could be attributed to its significantly higher (P<0.05) total phenol content, reducing power and free-radical scavenging ability. Therefore, dietary hot short pepper (Capsicum frutescens L. var. abbreviatum) could prevent cyclophosphamide-induced oxidative stress in brain; although the flesh is a better protectant, the possible contributory role of the seeds cannot be neglected. However, this protective effect of the pepper could be attributed to their antioxidant properties.

Authors+Show Affiliations

Biochemistry Department, Federal University of Technology, P.M.B. 704 Akure, Ondo State, Nigeria. goboh2001@yahoo.com <goboh2001@yahoo.com>No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19447589

Citation

Oboh, Ganiyu, and Omodesola O. Ogunruku. "Cyclophosphamide-induced Oxidative Stress in Brain: Protective Effect of Hot Short Pepper (Capsicum Frutescens L. Var. Abbreviatum)." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 62, no. 3, 2010, pp. 227-33.
Oboh G, Ogunruku OO. Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum). Exp Toxicol Pathol. 2010;62(3):227-33.
Oboh, G., & Ogunruku, O. O. (2010). Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum). Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 62(3), 227-33. https://doi.org/10.1016/j.etp.2009.03.011
Oboh G, Ogunruku OO. Cyclophosphamide-induced Oxidative Stress in Brain: Protective Effect of Hot Short Pepper (Capsicum Frutescens L. Var. Abbreviatum). Exp Toxicol Pathol. 2010;62(3):227-33. PubMed PMID: 19447589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum). AU - Oboh,Ganiyu, AU - Ogunruku,Omodesola O, Y1 - 2009/05/17/ PY - 2008/12/18/received PY - 2009/03/03/revised PY - 2009/03/31/accepted PY - 2009/5/19/entrez PY - 2009/5/19/pubmed PY - 2010/8/14/medline SP - 227 EP - 33 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp Toxicol Pathol VL - 62 IS - 3 N2 - This study sought to characterize the distribution of phenols and antioxidant activities in hot short pepper (Capsicum frutescens var. abbreviatum) and their inhibition of cyclophosphamide-induced oxidative stress in rat's brain. The total phenol content and antioxidant activities of pepper flesh (pericarp) and seeds were determined in vitro and in vivo. The results of the study revealed that intraperitoneal administration of cyclophosphamide (75mg/kg of body weight) caused a significant increase (P<0.05) in the malondialdehyde (MDA) content of the brain; however, there was a significant decrease (P<0.05) in the brain MDA content, in those of rats fed diet containing pepper; the flesh showed a higher inhibitory effect. In addition, dietary inclusion of the pepper (seed and flesh) also caused a dose-dependent inhibition of serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase and total bilirubin; likewise, dietary inclusion of the flesh inhibited MDA production than the seeds. The higher inhibition of oxidative stress in brain and serum enzymes and metabolites by the flesh could be attributed to its significantly higher (P<0.05) total phenol content, reducing power and free-radical scavenging ability. Therefore, dietary hot short pepper (Capsicum frutescens L. var. abbreviatum) could prevent cyclophosphamide-induced oxidative stress in brain; although the flesh is a better protectant, the possible contributory role of the seeds cannot be neglected. However, this protective effect of the pepper could be attributed to their antioxidant properties. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/19447589/Cyclophosphamide_induced_oxidative_stress_in_brain:_protective_effect_of_hot_short_pepper__Capsicum_frutescens_L__var__abbreviatum__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(09)00150-X DB - PRIME DP - Unbound Medicine ER -