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[Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets].
Yao Xue Xue Bao 2009; 44(3):270-5YX

Abstract

The pharmacokinetic research of traditional Chinese medicines (TMC) is an inalienable part of the chain of TCM modernization and plays an important role in the TCM novel drug development. However, the researching method and system that is consistent with the specific characteristics of TCM, i.e., multiple-components and targets, is still lacking. Furthermore, the current understanding of the critical scientific questions of TCM pharmacokinetics remains still unclear. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of TCMs, mainly including integral pharmacokinetic study of multiple components, herbalome analysis both in vitro and in vivo, mechanism based compatibility study for herbal components interactions, and the representative pharmacokinetic study for single herbal compound. Furthermore, the critical scientific questions of TCM pharmacokinetics are discussed based on understanding the requirements of novel drug developments from TCM.

Authors+Show Affiliations

Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

chi

PubMed ID

19449523

Citation

Hao, Hai-ping, et al. "[Thoughts and Experimental Exploration On Pharmacokinetic Study of Herbal Medicines With Multiple-components and Targets]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 44, no. 3, 2009, pp. 270-5.
Hao HP, Zheng CN, Wang GJ. [Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets]. Yao Xue Xue Bao. 2009;44(3):270-5.
Hao, H. P., Zheng, C. N., & Wang, G. J. (2009). [Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 44(3), pp. 270-5.
Hao HP, Zheng CN, Wang GJ. [Thoughts and Experimental Exploration On Pharmacokinetic Study of Herbal Medicines With Multiple-components and Targets]. Yao Xue Xue Bao. 2009;44(3):270-5. PubMed PMID: 19449523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets]. AU - Hao,Hai-ping, AU - Zheng,Chao-nan, AU - Wang,Guang-ji, PY - 2009/5/20/entrez PY - 2009/5/20/pubmed PY - 2010/3/12/medline SP - 270 EP - 5 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 44 IS - 3 N2 - The pharmacokinetic research of traditional Chinese medicines (TMC) is an inalienable part of the chain of TCM modernization and plays an important role in the TCM novel drug development. However, the researching method and system that is consistent with the specific characteristics of TCM, i.e., multiple-components and targets, is still lacking. Furthermore, the current understanding of the critical scientific questions of TCM pharmacokinetics remains still unclear. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of TCMs, mainly including integral pharmacokinetic study of multiple components, herbalome analysis both in vitro and in vivo, mechanism based compatibility study for herbal components interactions, and the representative pharmacokinetic study for single herbal compound. Furthermore, the critical scientific questions of TCM pharmacokinetics are discussed based on understanding the requirements of novel drug developments from TCM. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/19449523/[Thoughts_and_experimental_exploration_on_pharmacokinetic_study_of_herbal_medicines_with_multiple_components_and_targets]_ DB - PRIME DP - Unbound Medicine ER -