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CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension.
J Hypertens. 2009 Aug; 27(8):1594-601.JH

Abstract

OBJECTIVES

The longitudinal relationship between coffee use and hypertension is still controversial. Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine. The aim of the present study was to investigate the effect of coffee intake on the risk of developing hypertension needing antihypertensive treatment in individuals stratified by CYP1A2 genotype.

DESIGN

We assessed prospectively 553 young White individuals screened for stage 1 hypertension. Coffee intake was ascertained from regularly administered questionnaires. Incident physician-diagnosed hypertension was the outcome measure. Genotyping of CYP1A2 SNP was performed by real time PCR.

RESULTS

During a median follow-up of 8.2 years, 323 individuals developed hypertension. For carriers of the slow *1F allele (59%), hazard ratios of hypertension from multivariable Cox analysis were 1.00 in abstainers (reference), 1.72 (95%CI, 1.21-2.44) in moderate coffee drinkers (P = 0.03), and 3.00 (1.53-5.90) in heavy drinkers (P = 0.001). In contrast, hazard ratios for coffee drinkers with the rapid *1A/*1A genotype were 0.80 (0.52-1.23, P = 0.29) for moderate drinkers and 0.36 (0.14-0.89, P = 0.026) for heavy drinkers. In a two-way ANCOVA, a gene x coffee interactive effect was found on follow-up changes in systolic (P = 0.000) and diastolic (P = 0.007) blood pressure. Urinary epinephrine was higher in coffee drinkers than abstainers but only among individuals with slow *1F allele (P = 0.001).

CONCLUSION

These data show that the risk of hypertension associated with coffee intake varies according to CYP1A2 genotype. Carriers of slow *1F allele are at increased risk and should thus abstain from coffee, whereas individuals with *1A/*1A genotype can safely drink coffee.

Authors+Show Affiliations

Clinica Medica 4, University of Padova, via Giustiniani, 2- 35128 Padova, Italy. palatini@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19451835

Citation

Palatini, Paolo, et al. "CYP1A2 Genotype Modifies the Association Between Coffee Intake and the Risk of Hypertension." Journal of Hypertension, vol. 27, no. 8, 2009, pp. 1594-601.
Palatini P, Ceolotto G, Ragazzo F, et al. CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertens. 2009;27(8):1594-601.
Palatini, P., Ceolotto, G., Ragazzo, F., Dorigatti, F., Saladini, F., Papparella, I., Mos, L., Zanata, G., & Santonastaso, M. (2009). CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. Journal of Hypertension, 27(8), 1594-601. https://doi.org/10.1097/HJH.0b013e32832ba850
Palatini P, et al. CYP1A2 Genotype Modifies the Association Between Coffee Intake and the Risk of Hypertension. J Hypertens. 2009;27(8):1594-601. PubMed PMID: 19451835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. AU - Palatini,Paolo, AU - Ceolotto,Giulio, AU - Ragazzo,Fabio, AU - Dorigatti,Francesca, AU - Saladini,Francesca, AU - Papparella,Italia, AU - Mos,Lucio, AU - Zanata,Giuseppe, AU - Santonastaso,Massimo, PY - 2009/5/20/entrez PY - 2009/5/20/pubmed PY - 2009/10/1/medline SP - 1594 EP - 601 JF - Journal of hypertension JO - J Hypertens VL - 27 IS - 8 N2 - OBJECTIVES: The longitudinal relationship between coffee use and hypertension is still controversial. Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine. The aim of the present study was to investigate the effect of coffee intake on the risk of developing hypertension needing antihypertensive treatment in individuals stratified by CYP1A2 genotype. DESIGN: We assessed prospectively 553 young White individuals screened for stage 1 hypertension. Coffee intake was ascertained from regularly administered questionnaires. Incident physician-diagnosed hypertension was the outcome measure. Genotyping of CYP1A2 SNP was performed by real time PCR. RESULTS: During a median follow-up of 8.2 years, 323 individuals developed hypertension. For carriers of the slow *1F allele (59%), hazard ratios of hypertension from multivariable Cox analysis were 1.00 in abstainers (reference), 1.72 (95%CI, 1.21-2.44) in moderate coffee drinkers (P = 0.03), and 3.00 (1.53-5.90) in heavy drinkers (P = 0.001). In contrast, hazard ratios for coffee drinkers with the rapid *1A/*1A genotype were 0.80 (0.52-1.23, P = 0.29) for moderate drinkers and 0.36 (0.14-0.89, P = 0.026) for heavy drinkers. In a two-way ANCOVA, a gene x coffee interactive effect was found on follow-up changes in systolic (P = 0.000) and diastolic (P = 0.007) blood pressure. Urinary epinephrine was higher in coffee drinkers than abstainers but only among individuals with slow *1F allele (P = 0.001). CONCLUSION: These data show that the risk of hypertension associated with coffee intake varies according to CYP1A2 genotype. Carriers of slow *1F allele are at increased risk and should thus abstain from coffee, whereas individuals with *1A/*1A genotype can safely drink coffee. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/19451835/CYP1A2_genotype_modifies_the_association_between_coffee_intake_and_the_risk_of_hypertension_ L2 - https://doi.org/10.1097/HJH.0b013e32832ba850 DB - PRIME DP - Unbound Medicine ER -