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Does acute psychological stress increase perception of oesophageal acid?
Neurogastroenterol Motil 2009; 21(10):1055-e86NM

Abstract

Gastro-oesophageal reflux disease (GORD) patients often report an increase in their reflux symptoms during stressful situations. The aim of this study was to assess the influence of acute psychological stress on oesophageal acid perception. In 15 healthy volunteers and 10 GORD patients with a positive symptom-reflux association an oesophageal acid perfusion test was performed, once with and once without the presence of an acute psychological stressor (IQ test). The order of the measurements was randomized. The time from onset of the acid infusion to first acid perception, discomfort and pain was noted. Blood pressure was measured to assess the effect of the stress task. In healthy volunteers, the time to first perception (control task: 617 +/- 174 s vs stress task: 561 +/- 162 s), discomfort (control task: 969 +/- 158 s vs stress task: 940 +/- 151 s) or pain (control task: 1393 +/- 122 s vs stress task: 1366 +/- 121 s) did not differ significantly between both measurements. In GORD patients, no significant differences between both measurements were found either in time to first perception (control task: 63 +/- 26 s vs stress task: 43 +/- 15 s), discomfort (control task: 153 +/- 44 s vs stress task: 249 +/- 62 s) or pain (control task: 558 +/- 139 s vs stress task: 633 +/- 118 s). Systolic blood pressure rose significantly during the stress task in both the healthy volunteers (6 +/- 1 mmHg) and the GORD patients (9 +/- 2 mmHg). Neither in the healthy volunteers nor in the GORD patients, the acute psychological stress induced by an IQ test increased oesophageal acid perception. The observed increase in systolic blood pressure shows that the experimental stressors were effective.

Authors+Show Affiliations

Department of Gastroenterology, St Antonius Hospital, Nieuwegein, The Netherlands. m.hemmink@antonius.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19453516

Citation

Hemmink, G J M., et al. "Does Acute Psychological Stress Increase Perception of Oesophageal Acid?" Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 21, no. 10, 2009, pp. 1055-e86.
Hemmink GJ, Bredenoord AJ, Weusten BL, et al. Does acute psychological stress increase perception of oesophageal acid? Neurogastroenterol Motil. 2009;21(10):1055-e86.
Hemmink, G. J., Bredenoord, A. J., Weusten, B. L., Timmer, R., & Smout, A. J. (2009). Does acute psychological stress increase perception of oesophageal acid? Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 21(10), pp. 1055-e86. doi:10.1111/j.1365-2982.2009.01327.x.
Hemmink GJ, et al. Does Acute Psychological Stress Increase Perception of Oesophageal Acid. Neurogastroenterol Motil. 2009;21(10):1055-e86. PubMed PMID: 19453516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does acute psychological stress increase perception of oesophageal acid? AU - Hemmink,G J M, AU - Bredenoord,A J, AU - Weusten,B L A M, AU - Timmer,R, AU - Smout,A J P M, Y1 - 2009/05/15/ PY - 2009/5/21/entrez PY - 2009/5/21/pubmed PY - 2009/11/18/medline SP - 1055 EP - e86 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 21 IS - 10 N2 - Gastro-oesophageal reflux disease (GORD) patients often report an increase in their reflux symptoms during stressful situations. The aim of this study was to assess the influence of acute psychological stress on oesophageal acid perception. In 15 healthy volunteers and 10 GORD patients with a positive symptom-reflux association an oesophageal acid perfusion test was performed, once with and once without the presence of an acute psychological stressor (IQ test). The order of the measurements was randomized. The time from onset of the acid infusion to first acid perception, discomfort and pain was noted. Blood pressure was measured to assess the effect of the stress task. In healthy volunteers, the time to first perception (control task: 617 +/- 174 s vs stress task: 561 +/- 162 s), discomfort (control task: 969 +/- 158 s vs stress task: 940 +/- 151 s) or pain (control task: 1393 +/- 122 s vs stress task: 1366 +/- 121 s) did not differ significantly between both measurements. In GORD patients, no significant differences between both measurements were found either in time to first perception (control task: 63 +/- 26 s vs stress task: 43 +/- 15 s), discomfort (control task: 153 +/- 44 s vs stress task: 249 +/- 62 s) or pain (control task: 558 +/- 139 s vs stress task: 633 +/- 118 s). Systolic blood pressure rose significantly during the stress task in both the healthy volunteers (6 +/- 1 mmHg) and the GORD patients (9 +/- 2 mmHg). Neither in the healthy volunteers nor in the GORD patients, the acute psychological stress induced by an IQ test increased oesophageal acid perception. The observed increase in systolic blood pressure shows that the experimental stressors were effective. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/19453516/Does_acute_psychological_stress_increase_perception_of_oesophageal_acid L2 - https://doi.org/10.1111/j.1365-2982.2009.01327.x DB - PRIME DP - Unbound Medicine ER -