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Cobalamin, folic acid, and homocysteine.
Nutr Rev. 2009 May; 67 Suppl 1:S69-72.NR

Abstract

Cobalamin deficiency can lead to several adverse health consequences: folate trapping in the methylation cycle and subsequent impaired DNA biosynthesis; pernicious anemia hematologically, similar to that caused by folate deficiency; elevated blood homocysteine (tHcy) (risk factor for cardiovascular disease and adverse pregnancy outcomes); and neural tube defects (NTDs). Population-wide folate status is expected to improve where folic acid fortification policies for reducing NTD occurrence are established. However, there is concern that cobalamin deficiency and its characteristic neuropathy could be masked when hematological abnormalities in risk groups such as the elderly and vegetarians are reversed through folic acid supplementation. Folate-cobalamin interactions and their impact on health are reviewed here.

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Aggregator Full Text
Publisher Full Text
academic.oup.com
onlinelibrary.wiley.com

Authors+Show Affiliations

Varela-Moreiras G
Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Universidad San Pablo CEU, Facultad de Farmacia, Madrid, Spain.
Murphy MM
No affiliation info available
Scott JM
No affiliation info available

MeSH

AdultAgedCardiovascular DiseasesFemaleFolic AcidFolic Acid DeficiencyFood, FortifiedHomocysteineHumansNeural Tube DefectsNutritional RequirementsNutritional StatusPregnancyVitamin B 12Vitamin B 12 DeficiencyVitamin B Complex

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19453682

Citation

Varela-Moreiras, Gregorio, et al. "Cobalamin, Folic Acid, and Homocysteine." Nutrition Reviews, vol. 67 Suppl 1, 2009, pp. S69-72.
Varela-Moreiras G, Murphy MM, Scott JM. Cobalamin, folic acid, and homocysteine. Nutr Rev. 2009;67 Suppl 1:S69-72.
Varela-Moreiras, G., Murphy, M. M., & Scott, J. M. (2009). Cobalamin, folic acid, and homocysteine. Nutrition Reviews, 67 Suppl 1, S69-72. https://doi.org/10.1111/j.1753-4887.2009.00163.x
Varela-Moreiras G, Murphy MM, Scott JM. Cobalamin, Folic Acid, and Homocysteine. Nutr Rev. 2009;67 Suppl 1:S69-72. PubMed PMID: 19453682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cobalamin, folic acid, and homocysteine. AU - Varela-Moreiras,Gregorio, AU - Murphy,Michelle M, AU - Scott,John M, PY - 2009/5/21/entrez PY - 2009/7/2/pubmed PY - 2009/8/19/medline SP - S69 EP - 72 JF - Nutrition reviews JO - Nutr Rev VL - 67 Suppl 1 N2 - Cobalamin deficiency can lead to several adverse health consequences: folate trapping in the methylation cycle and subsequent impaired DNA biosynthesis; pernicious anemia hematologically, similar to that caused by folate deficiency; elevated blood homocysteine (tHcy) (risk factor for cardiovascular disease and adverse pregnancy outcomes); and neural tube defects (NTDs). Population-wide folate status is expected to improve where folic acid fortification policies for reducing NTD occurrence are established. However, there is concern that cobalamin deficiency and its characteristic neuropathy could be masked when hematological abnormalities in risk groups such as the elderly and vegetarians are reversed through folic acid supplementation. Folate-cobalamin interactions and their impact on health are reviewed here. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/19453682/Cobalamin_folic_acid_and_homocysteine_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/j.1753-4887.2009.00163.x DB - PRIME DP - Unbound Medicine ER -