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Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype.
Hum Reprod. 2009 Sep; 24(9):2286-92.HR

Abstract

BACKGROUND

Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) but its prevalence in different PCOS phenotypes is still largely unknown.

METHODS

We measured plasma lipids and lipoproteins in 35 anovulatory PCOS (age: 25 +/- 6 years, BMI: 28 +/- 6 kg/m(2)), 15 ovulatory PCOS (age: 30 +/- 6 years, BMI: 25 +/- 3 kg/m(2)) and 27 healthy women (controls) age- and BMI-matched with ovulatory PCOS. PCOS was diagnosed by the presence of clinical or biologic hyperandrogenism associated with chronic anovulation and/or polycystic ovaries at ultrasound. In women with normal menses chronic anovulation was indicated by low serum progesterone levels (<9.54 nmol/l) during midluteal phase (days 21-24) in two consecutive menstrual cycles.

RESULTS

Total cholesterol, triglycerides and low-density lipoprotein (LDL)-cholesterol levels increased and high-density lipoprotein (HDL)-cholesterol decreased from controls to ovulatory and then to anovulatory PCOS (all P < 0.05). Levels of lipoprotein(a) (Lp(a)) and small, dense LDL increased (P < 0.0001 for both) and LDL size reduced (P < 0.005) between groups. Insulin resistance (by HOMA) showed a positive correlation with triglycerides and small, dense LDL and an inverse correlation with HDL-cholesterol and LDL size (P < 0.05 for all) in both PCOS phenotypes. No significant correlations were found with testosterone levels. At multivariate analysis, insulin resistance was independently associated with HDL-cholesterol and small, dense LDL in both PCOS phenotypes and with triglyceride concentrations in ovulatory PCOS only.

CONCLUSIONS

Women with ovulatory PCOS showed milder forms of atherogenic dyslipidemia than anovulatory PCOS and this seemed to be related to the extent of insulin resistance. Future prospective studies are needed to assess the relative contribution of such alterations on cardiovascular risk.

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Authors+Show Affiliations

Rizzo M
Department of Internal Medicine and Emerging Diseases, University of Palermo, Via del Vespro, 141, 90127 Palermo, Italy.
Berneis K
No affiliation info available
Hersberger M
No affiliation info available
Pepe I
No affiliation info available
Di Fede G
No affiliation info available
Rini GB
No affiliation info available
Spinas GA
No affiliation info available
Carmina E
No affiliation info available

MeSH

AdultAtherosclerosisCholesterolCholesterol, LDLDyslipidemiasFemaleHumansOvulationPolycystic Ovary SyndromeRisk FactorsTriglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19454589

Citation

Rizzo, Manfredi, et al. "Milder Forms of Atherogenic Dyslipidemia in Ovulatory Versus Anovulatory Polycystic Ovary Syndrome Phenotype." Human Reproduction (Oxford, England), vol. 24, no. 9, 2009, pp. 2286-92.
Rizzo M, Berneis K, Hersberger M, et al. Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype. Hum Reprod. 2009;24(9):2286-92.
Rizzo, M., Berneis, K., Hersberger, M., Pepe, I., Di Fede, G., Rini, G. B., Spinas, G. A., & Carmina, E. (2009). Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype. Human Reproduction (Oxford, England), 24(9), 2286-92. https://doi.org/10.1093/humrep/dep121
Rizzo M, et al. Milder Forms of Atherogenic Dyslipidemia in Ovulatory Versus Anovulatory Polycystic Ovary Syndrome Phenotype. Hum Reprod. 2009;24(9):2286-92. PubMed PMID: 19454589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype. AU - Rizzo,Manfredi, AU - Berneis,Kaspar, AU - Hersberger,Martin, AU - Pepe,Ilenia, AU - Di Fede,Gaetana, AU - Rini,Giovam Battista, AU - Spinas,Giatgen A, AU - Carmina,Enrico, Y1 - 2009/05/19/ PY - 2009/5/21/entrez PY - 2009/5/21/pubmed PY - 2009/11/11/medline SP - 2286 EP - 92 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 24 IS - 9 N2 - BACKGROUND: Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) but its prevalence in different PCOS phenotypes is still largely unknown. METHODS: We measured plasma lipids and lipoproteins in 35 anovulatory PCOS (age: 25 +/- 6 years, BMI: 28 +/- 6 kg/m(2)), 15 ovulatory PCOS (age: 30 +/- 6 years, BMI: 25 +/- 3 kg/m(2)) and 27 healthy women (controls) age- and BMI-matched with ovulatory PCOS. PCOS was diagnosed by the presence of clinical or biologic hyperandrogenism associated with chronic anovulation and/or polycystic ovaries at ultrasound. In women with normal menses chronic anovulation was indicated by low serum progesterone levels (<9.54 nmol/l) during midluteal phase (days 21-24) in two consecutive menstrual cycles. RESULTS: Total cholesterol, triglycerides and low-density lipoprotein (LDL)-cholesterol levels increased and high-density lipoprotein (HDL)-cholesterol decreased from controls to ovulatory and then to anovulatory PCOS (all P < 0.05). Levels of lipoprotein(a) (Lp(a)) and small, dense LDL increased (P < 0.0001 for both) and LDL size reduced (P < 0.005) between groups. Insulin resistance (by HOMA) showed a positive correlation with triglycerides and small, dense LDL and an inverse correlation with HDL-cholesterol and LDL size (P < 0.05 for all) in both PCOS phenotypes. No significant correlations were found with testosterone levels. At multivariate analysis, insulin resistance was independently associated with HDL-cholesterol and small, dense LDL in both PCOS phenotypes and with triglyceride concentrations in ovulatory PCOS only. CONCLUSIONS: Women with ovulatory PCOS showed milder forms of atherogenic dyslipidemia than anovulatory PCOS and this seemed to be related to the extent of insulin resistance. Future prospective studies are needed to assess the relative contribution of such alterations on cardiovascular risk. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/19454589/Milder_forms_of_atherogenic_dyslipidemia_in_ovulatory_versus_anovulatory_polycystic_ovary_syndrome_phenotype_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dep121 DB - PRIME DP - Unbound Medicine ER -