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Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project.
Am J Geriatr Psychiatry. 2009 Mar; 17(3):227-36.AJ

Abstract

OBJECTIVES

Previous research has suggested that mental stimulation in different life periods may protect against dementia or delay disease onset. This study aimed to explore the association between work complexity factors at midlife and dementia risk in late life under the hypothesis that high work complexity may modulate the increased dementia risk due to low education.

DESIGN

Population-based follow-up study.

SETTING

Urban.

PARTICIPANTS

A cohort of 931 nondemented subjects, aged 75+ years from the Kungsholmen Project, Stockholm, examined twice over 6 years.

MEASUREMENTS

Incident dementia cases were identified using Diagnostic and Statistical Manual of Mental Disorders, 3rd-Edition Revised criteria. Primary occupations were assigned into categories according to the Nordic Occupational Classification and matched to the 1970 U.S. Census to score the level of work complexity with data, people, and things by using a preformed matrix.

RESULTS

Lower dementia risk was associated with complexity of work with both data (age and gender adjusted relative risk [aRR]: 0.85, 95% confidence interval [CI]: 0.75-0.95) and with people (aRR: 0.88, 95% CI: 0.80-0.97). Adjusting for education led to similar results, although no longer statistically significant. Further, the highest degrees of complexity of work with data that involves analyzing, coordinating, and synthesizing data were associated with lower dementia risk even among lower educated subjects (relative risk: 0.52, 95% CI: 0.29-0.95). No gender differences were detected.

CONCLUSIONS

This study suggests that work complexity with data and people is related to lower risk of dementia and that the highest levels of work complexity may modulate the higher dementia risk due to low education.

Authors+Show Affiliations

Aging Research Center, Karolinska Institutet, and the Stockholm Gerontology Research Center, Gävlegatan 16, Stockholm, Sweden. anita.karp@.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19454849

Citation

Karp, Anita, et al. "Mentally Stimulating Activities at Work During Midlife and Dementia Risk After Age 75: Follow-up Study From the Kungsholmen Project." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 17, no. 3, 2009, pp. 227-36.
Karp A, Andel R, Parker MG, et al. Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project. Am J Geriatr Psychiatry. 2009;17(3):227-36.
Karp, A., Andel, R., Parker, M. G., Wang, H. X., Winblad, B., & Fratiglioni, L. (2009). Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 17(3), 227-36. https://doi.org/10.1097/JGP.0b013e318190b691
Karp A, et al. Mentally Stimulating Activities at Work During Midlife and Dementia Risk After Age 75: Follow-up Study From the Kungsholmen Project. Am J Geriatr Psychiatry. 2009;17(3):227-36. PubMed PMID: 19454849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project. AU - Karp,Anita, AU - Andel,Ross, AU - Parker,Marti G, AU - Wang,Hui-Xin, AU - Winblad,Bengt, AU - Fratiglioni,Laura, PY - 2009/5/21/entrez PY - 2009/5/21/pubmed PY - 2009/7/14/medline SP - 227 EP - 36 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 17 IS - 3 N2 - OBJECTIVES: Previous research has suggested that mental stimulation in different life periods may protect against dementia or delay disease onset. This study aimed to explore the association between work complexity factors at midlife and dementia risk in late life under the hypothesis that high work complexity may modulate the increased dementia risk due to low education. DESIGN: Population-based follow-up study. SETTING: Urban. PARTICIPANTS: A cohort of 931 nondemented subjects, aged 75+ years from the Kungsholmen Project, Stockholm, examined twice over 6 years. MEASUREMENTS: Incident dementia cases were identified using Diagnostic and Statistical Manual of Mental Disorders, 3rd-Edition Revised criteria. Primary occupations were assigned into categories according to the Nordic Occupational Classification and matched to the 1970 U.S. Census to score the level of work complexity with data, people, and things by using a preformed matrix. RESULTS: Lower dementia risk was associated with complexity of work with both data (age and gender adjusted relative risk [aRR]: 0.85, 95% confidence interval [CI]: 0.75-0.95) and with people (aRR: 0.88, 95% CI: 0.80-0.97). Adjusting for education led to similar results, although no longer statistically significant. Further, the highest degrees of complexity of work with data that involves analyzing, coordinating, and synthesizing data were associated with lower dementia risk even among lower educated subjects (relative risk: 0.52, 95% CI: 0.29-0.95). No gender differences were detected. CONCLUSIONS: This study suggests that work complexity with data and people is related to lower risk of dementia and that the highest levels of work complexity may modulate the higher dementia risk due to low education. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/19454849/Mentally_stimulating_activities_at_work_during_midlife_and_dementia_risk_after_age_75:_follow_up_study_from_the_Kungsholmen_Project_ L2 - https://linkinghub.elsevier.com/retrieve/pii/00019442-200903000-00007 DB - PRIME DP - Unbound Medicine ER -