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Skin impedance correlates to sedation grade, plasma propofol concentrations and bispectral index during a target-controlled infusion of propofol.
Eur J Anaesthesiol. 2009 Jul; 26(7):589-96.EJ

Abstract

BACKGROUND AND OBJECTIVE

Sympathetic activity, measured as changes in electrical skin impedance, may be used to assess the adequacy of general anaesthesia. The aim of this prospective study was to evaluate electrical skin impedance in comparison with bispectral index values and the Observer's Assessment of Alertness and Sedation (OAAS) scale during propofol infusion.

METHODS

Electrical skin impedance was measured with an electrosympathicograph. In 22 patients and eight healthy volunteers, anaesthesia was induced and maintained with propofol that was administered via a target-controlled infusion pump at increasing plasma concentrations. Bispectral index, electrosympathicograph and OAAS values were compared at six successive predicted target plasma concentrations (T 1-6: 0, 1.3, 1.7, 2.0, 2.4 and 2.8 microg ml(-1)).

RESULTS

The changes in the electrical skin impedance measured with the assistance of the electrosympathicograph correlated with the changes in bispectral index values at each measurement time point and during the whole course (P < 0.0001), with the target plasma propofol concentrations (P < 0.0001), and with the OAAS scale (P < 0.0001).

CONCLUSION

The observed correlations between electrical skin impedance, predicted plasma concentrations of propofol and OAAS scale appear to justify further investigation of skin impedance as a depth of anaesthesia monitor.

Authors+Show Affiliations

Department of Anaesthesiology, University of Duesseldorf, Duesseldorf, Germany. michael.winterhalter@med.uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

19455042

Citation

Winterhalter, Michael, et al. "Skin Impedance Correlates to Sedation Grade, Plasma Propofol Concentrations and Bispectral Index During a Target-controlled Infusion of Propofol." European Journal of Anaesthesiology, vol. 26, no. 7, 2009, pp. 589-96.
Winterhalter M, Münte S, Taschenbrecker P, et al. Skin impedance correlates to sedation grade, plasma propofol concentrations and bispectral index during a target-controlled infusion of propofol. Eur J Anaesthesiol. 2009;26(7):589-96.
Winterhalter, M., Münte, S., Taschenbrecker, P., Hecker, H., Weilbach, C., Osthaus, A. W., Gross, M., Piepenbrock, S., & Rahe-Meyer, N. (2009). Skin impedance correlates to sedation grade, plasma propofol concentrations and bispectral index during a target-controlled infusion of propofol. European Journal of Anaesthesiology, 26(7), 589-96. https://doi.org/10.1097/EJA.0b013e328329b149
Winterhalter M, et al. Skin Impedance Correlates to Sedation Grade, Plasma Propofol Concentrations and Bispectral Index During a Target-controlled Infusion of Propofol. Eur J Anaesthesiol. 2009;26(7):589-96. PubMed PMID: 19455042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin impedance correlates to sedation grade, plasma propofol concentrations and bispectral index during a target-controlled infusion of propofol. AU - Winterhalter,Michael, AU - Münte,Sinikka, AU - Taschenbrecker,Peter, AU - Hecker,Hartmut, AU - Weilbach,Christian, AU - Osthaus,Alexander W, AU - Gross,Matthias, AU - Piepenbrock,Siegfried, AU - Rahe-Meyer,Niels, PY - 2009/5/21/entrez PY - 2009/5/21/pubmed PY - 2009/8/19/medline SP - 589 EP - 96 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 26 IS - 7 N2 - BACKGROUND AND OBJECTIVE: Sympathetic activity, measured as changes in electrical skin impedance, may be used to assess the adequacy of general anaesthesia. The aim of this prospective study was to evaluate electrical skin impedance in comparison with bispectral index values and the Observer's Assessment of Alertness and Sedation (OAAS) scale during propofol infusion. METHODS: Electrical skin impedance was measured with an electrosympathicograph. In 22 patients and eight healthy volunteers, anaesthesia was induced and maintained with propofol that was administered via a target-controlled infusion pump at increasing plasma concentrations. Bispectral index, electrosympathicograph and OAAS values were compared at six successive predicted target plasma concentrations (T 1-6: 0, 1.3, 1.7, 2.0, 2.4 and 2.8 microg ml(-1)). RESULTS: The changes in the electrical skin impedance measured with the assistance of the electrosympathicograph correlated with the changes in bispectral index values at each measurement time point and during the whole course (P < 0.0001), with the target plasma propofol concentrations (P < 0.0001), and with the OAAS scale (P < 0.0001). CONCLUSION: The observed correlations between electrical skin impedance, predicted plasma concentrations of propofol and OAAS scale appear to justify further investigation of skin impedance as a depth of anaesthesia monitor. SN - 1365-2346 UR - https://www.unboundmedicine.com/medline/citation/19455042/Skin_impedance_correlates_to_sedation_grade_plasma_propofol_concentrations_and_bispectral_index_during_a_target_controlled_infusion_of_propofol_ L2 - https://doi.org/10.1097/EJA.0b013e328329b149 DB - PRIME DP - Unbound Medicine ER -