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Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models.
Methods Find Exp Clin Pharmacol. 2009 Mar; 31(2):81-8.MF

Abstract

The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses.

Authors+Show Affiliations

Pharmacogenomics Center, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19455262

Citation

Zakaria, Z A., et al. "Antinociceptive, Anti-inflammatory and Antipyretic Effects of Solanum Nigrum Aqueous Extract in Animal Models." Methods and Findings in Experimental and Clinical Pharmacology, vol. 31, no. 2, 2009, pp. 81-8.
Zakaria ZA, Sulaiman MR, Morsid NA, et al. Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models. Methods Find Exp Clin Pharmacol. 2009;31(2):81-8.
Zakaria, Z. A., Sulaiman, M. R., Morsid, N. A., Aris, A., Zainal, H., Pojan, N. H., & Kumar, G. H. (2009). Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models. Methods and Findings in Experimental and Clinical Pharmacology, 31(2), 81-8. https://doi.org/10.1358/mf.2009.31.2.1353876
Zakaria ZA, et al. Antinociceptive, Anti-inflammatory and Antipyretic Effects of Solanum Nigrum Aqueous Extract in Animal Models. Methods Find Exp Clin Pharmacol. 2009;31(2):81-8. PubMed PMID: 19455262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models. AU - Zakaria,Z A, AU - Sulaiman,M R, AU - Morsid,N A, AU - Aris,A, AU - Zainal,H, AU - Pojan,N H Mohd, AU - Kumar,G Hanan, PY - 2009/5/21/entrez PY - 2009/5/21/pubmed PY - 2009/8/12/medline SP - 81 EP - 8 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 31 IS - 2 N2 - The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/19455262/Antinociceptive_anti_inflammatory_and_antipyretic_effects_of_Solanum_nigrum_aqueous_extract_in_animal_models_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&amp;p_RefId=1353876 DB - PRIME DP - Unbound Medicine ER -