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The effects of feeding with different levels of zinc and chromium on plasma thiobarbituric acid reactive substances and antioxidant enzymes in rats.
Pol J Vet Sci. 2009; 12(1):35-9.PJ

Abstract

This study was designed to investigate the effects of supplementation and deficiency of dietary chromium (Cr), zinc (Zn) and combination of zinc and chromium on lipid peroxidation and antioxidant enzymes. A total of 84 male Wistar albino rats were fed rat chow containing different levels of Zn and Cr throughout the 84 days. Blood samples were collected for analysis of Thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px). TBARS concentrations in rats fed high-Cr diet, high-Zn and Cr diet and low-Zn diet were significantly higher than those determined in the control group (p < or = 0.05). CAT activities in rats fed high-Cr diet were significantly higher than those observed in the control group. Cu-Zn SOD and GSH-Px activities were significantly higher in rats fed high-Cr diet, high-Zn and Cr diet, low-Zn diet, and low-Zn and Cr diet when compared to the activities found in the controls. These results suggest that trivalent chromium supplementation increase antioxidant enzymes by enhancement of lipid peroxidation, but Zn supplementation does not have any effect on lipid peroxidation. Also Zn deficiency resulted in increased lipid peroxidation, SOD and GSH-Px activities because of the oxidative stress caused by zinc deficiency.

Authors+Show Affiliations

Esen Gursel F
Istanbul University, Faculty of Veterinary Medicine Department of Biochemistry 34320 Avcilar, Istanbul, Turkey. fesen@istanbul.edu.tr
Tekeli SK
No affiliation info available

MeSH

Animal FeedAnimal Nutritional Physiological PhenomenaAnimalsAntioxidantsCatalaseChromiumDietDose-Response Relationship, DrugDrug Therapy, CombinationGlutathione PeroxidaseLipid PeroxidationMaleRatsSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesZinc

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19459437

Citation

Esen Gursel, F, and S K. Tekeli. "The Effects of Feeding With Different Levels of Zinc and Chromium On Plasma Thiobarbituric Acid Reactive Substances and Antioxidant Enzymes in Rats." Polish Journal of Veterinary Sciences, vol. 12, no. 1, 2009, pp. 35-9.
Esen Gursel F, Tekeli SK. The effects of feeding with different levels of zinc and chromium on plasma thiobarbituric acid reactive substances and antioxidant enzymes in rats. Pol J Vet Sci. 2009;12(1):35-9.
Esen Gursel, F., & Tekeli, S. K. (2009). The effects of feeding with different levels of zinc and chromium on plasma thiobarbituric acid reactive substances and antioxidant enzymes in rats. Polish Journal of Veterinary Sciences, 12(1), 35-9.
Esen Gursel F, Tekeli SK. The Effects of Feeding With Different Levels of Zinc and Chromium On Plasma Thiobarbituric Acid Reactive Substances and Antioxidant Enzymes in Rats. Pol J Vet Sci. 2009;12(1):35-9. PubMed PMID: 19459437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of feeding with different levels of zinc and chromium on plasma thiobarbituric acid reactive substances and antioxidant enzymes in rats. AU - Esen Gursel,F, AU - Tekeli,S K, PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2009/7/3/medline SP - 35 EP - 9 JF - Polish journal of veterinary sciences JO - Pol J Vet Sci VL - 12 IS - 1 N2 - This study was designed to investigate the effects of supplementation and deficiency of dietary chromium (Cr), zinc (Zn) and combination of zinc and chromium on lipid peroxidation and antioxidant enzymes. A total of 84 male Wistar albino rats were fed rat chow containing different levels of Zn and Cr throughout the 84 days. Blood samples were collected for analysis of Thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px). TBARS concentrations in rats fed high-Cr diet, high-Zn and Cr diet and low-Zn diet were significantly higher than those determined in the control group (p < or = 0.05). CAT activities in rats fed high-Cr diet were significantly higher than those observed in the control group. Cu-Zn SOD and GSH-Px activities were significantly higher in rats fed high-Cr diet, high-Zn and Cr diet, low-Zn diet, and low-Zn and Cr diet when compared to the activities found in the controls. These results suggest that trivalent chromium supplementation increase antioxidant enzymes by enhancement of lipid peroxidation, but Zn supplementation does not have any effect on lipid peroxidation. Also Zn deficiency resulted in increased lipid peroxidation, SOD and GSH-Px activities because of the oxidative stress caused by zinc deficiency. SN - 1505-1773 UR - https://www.unboundmedicine.com/medline/citation/19459437/The_effects_of_feeding_with_different_levels_of_zinc_and_chromium_on_plasma_thiobarbituric_acid_reactive_substances_and_antioxidant_enzymes_in_rats_ DB - PRIME DP - Unbound Medicine ER -