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[Oxidized LDL and C-reactive protein level in relation to carotid intima-media thickness in population with risk factors for atherosclerosis].
Srp Arh Celok Lek 2009 Mar-Apr; 137(3-4):140-5SA

Abstract

INTRODUCTION

Elevated levels of oxidized LDL cholesterol (OxLDL) are considered to be a key factor of initiating and accelerating atherosclerosis. It promotes atherosclerosis through inflammatory and immunologic mechanisms that lead to the formation of macrophage foam cells.

OBJECTIVE

To determine the relationship among OxLDL, C-reactive protein (CRP) level and carotid intima-media thickness (IMT) in population with risk factors for atherosclerosis.

METHODS

The study group consisted of 125 clinically healthy, hypercholesterolaemic subjects (49.3 +/- 5.7 years; 75 females and 50 males) compared with 100 age-matched population-based control subjects. The study group was divided into two subgroups: subgroup A (the levels of LDL cholesterol > 5 mmol/L) and subgroup B (the levels of LDL cholesterol < 5 mmol/L). None of the subjects had history of cerebrovascular, ischaemic heart disease, hypertension or diabetes mellitus. Lipid profiles were measured by enzymatic methods. OxLDL was measured by using a specific monoclonal antibody, mAb4E6. CRP was measured using hemiluminescent methods (Immulite-DPC). The common carotid IMT was measured by the B-mode ultrasound.

RESULTS

Compared to controls, the study group had higher levels of OxLDL (119.97 +/- 43.15 vs. 82.03 +/- 25.99 IU/L; p < 0.01) and CRP (6.20 +/- 3.55 vs. 2.68 +/- 3.04 mg/ml; p < 0.05). IMT was significantly higher in study subjects (1.14 +/- 0.38 vs. 0.72 +/- 0.24 mm; p < 0.05). We also found that, in the whole study group, IMT significantly positively correlated with OxLDL (r = 0.442; p < 0.05). We found that in the study subgroup A, IMT positively correlated with CRP (r = 0.792; p < 0.01). In controls, we found a significantly positive association between IMT and OxLDL (r = 0.781; p < 0.01) and CRP (r = 0.748; p < 0.01).

CONCLUSION

The elevated levels of OxLDL and CRP are associated with higher common carotid intima-media thickness in population with risk factors for atherosclerosis.

Authors

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Pub Type(s)

Journal Article

Language

srp

PubMed ID

19459559

Citation

Caparević, Zorica, et al. "[Oxidized LDL and C-reactive Protein Level in Relation to Carotid Intima-media Thickness in Population With Risk Factors for Atherosclerosis]." Srpski Arhiv Za Celokupno Lekarstvo, vol. 137, no. 3-4, 2009, pp. 140-5.
Caparević Z, Kostić N, Ilić S, et al. [Oxidized LDL and C-reactive protein level in relation to carotid intima-media thickness in population with risk factors for atherosclerosis]. Srp Arh Celok Lek. 2009;137(3-4):140-5.
Caparević, Z., Kostić, N., Ilić, S., Radojković, J., Marina, D. j., Pencić, B., & Radojković, I. (2009). [Oxidized LDL and C-reactive protein level in relation to carotid intima-media thickness in population with risk factors for atherosclerosis]. Srpski Arhiv Za Celokupno Lekarstvo, 137(3-4), pp. 140-5.
Caparević Z, et al. [Oxidized LDL and C-reactive Protein Level in Relation to Carotid Intima-media Thickness in Population With Risk Factors for Atherosclerosis]. Srp Arh Celok Lek. 2009;137(3-4):140-5. PubMed PMID: 19459559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Oxidized LDL and C-reactive protein level in relation to carotid intima-media thickness in population with risk factors for atherosclerosis]. AU - Caparević,Zorica, AU - Kostić,Nada, AU - Ilić,Sanja, AU - Radojković,Jana, AU - Marina,Djordje, AU - Pencić,Biljana, AU - Radojković,Ivan, PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2009/6/10/medline SP - 140 EP - 5 JF - Srpski arhiv za celokupno lekarstvo JO - Srp Arh Celok Lek VL - 137 IS - 3-4 N2 - INTRODUCTION: Elevated levels of oxidized LDL cholesterol (OxLDL) are considered to be a key factor of initiating and accelerating atherosclerosis. It promotes atherosclerosis through inflammatory and immunologic mechanisms that lead to the formation of macrophage foam cells. OBJECTIVE: To determine the relationship among OxLDL, C-reactive protein (CRP) level and carotid intima-media thickness (IMT) in population with risk factors for atherosclerosis. METHODS: The study group consisted of 125 clinically healthy, hypercholesterolaemic subjects (49.3 +/- 5.7 years; 75 females and 50 males) compared with 100 age-matched population-based control subjects. The study group was divided into two subgroups: subgroup A (the levels of LDL cholesterol > 5 mmol/L) and subgroup B (the levels of LDL cholesterol < 5 mmol/L). None of the subjects had history of cerebrovascular, ischaemic heart disease, hypertension or diabetes mellitus. Lipid profiles were measured by enzymatic methods. OxLDL was measured by using a specific monoclonal antibody, mAb4E6. CRP was measured using hemiluminescent methods (Immulite-DPC). The common carotid IMT was measured by the B-mode ultrasound. RESULTS: Compared to controls, the study group had higher levels of OxLDL (119.97 +/- 43.15 vs. 82.03 +/- 25.99 IU/L; p < 0.01) and CRP (6.20 +/- 3.55 vs. 2.68 +/- 3.04 mg/ml; p < 0.05). IMT was significantly higher in study subjects (1.14 +/- 0.38 vs. 0.72 +/- 0.24 mm; p < 0.05). We also found that, in the whole study group, IMT significantly positively correlated with OxLDL (r = 0.442; p < 0.05). We found that in the study subgroup A, IMT positively correlated with CRP (r = 0.792; p < 0.01). In controls, we found a significantly positive association between IMT and OxLDL (r = 0.781; p < 0.01) and CRP (r = 0.748; p < 0.01). CONCLUSION: The elevated levels of OxLDL and CRP are associated with higher common carotid intima-media thickness in population with risk factors for atherosclerosis. SN - 0370-8179 UR - https://www.unboundmedicine.com/medline/citation/19459559/[Oxidized_LDL_and_C_reactive_protein_level_in_relation_to_carotid_intima_media_thickness_in_population_with_risk_factors_for_atherosclerosis]_ L2 - http://srpskiarhiv.rs/global/pdf/articles-2009/mart-april/OxidizedLDLandC-reactiveproteinlevelinrelationtocarotidintima-mediathicknessinpopulationwithriskfactorsforatherosclerosis.pdf DB - PRIME DP - Unbound Medicine ER -