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Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats.
J Med Food. 2009 Apr; 12(2):327-33.JM

Abstract

The protective effect of Emblica officinalis, a commonly used botanical in many Ayurvedic preparations, was investigated for its effects on liver mitochondria of ethanol-administered rats. Oxidative stress and reactive oxygen species-mediated toxicity are considered two of the key underlying mechanisms responsible for alcohol-induced liver injury and mitochondrial dysfunction. Alcohol-administered rats showed a significant elevation of plasma transaminases (aspartate and alanine aminotransferases), alkaline phosphatase, and gamma-glutamyl transferase compared to control rats. However, activities of hepatic mitochondrial antioxidant enzymes, viz., superoxide dismutase, glutathione peroxidase, and reduced glutathione, were significantly lower. Chronic alcohol feeding also increased lipid peroxide levels, protein carbonyl content, and overproduction of nitric oxide followed by lowered activities of NADH dehydrogenase, succinate dehydrogenase (SDH), and cytochrome c oxidase and content of cytochromes. Administration of E. officinalis fruit extract (EFE) at a dose of 250 mg/kg of body weight/day to alcoholic rats offers protection by simultaneously lowering the carbonyl content and lipid peroxidation and elevating antioxidant enzyme activities, SDH, NADH dehydrogenase, and cytochrome c oxidase activities, and content of cytochromes in hepatic mitochondria. Our data indicate that EFE administration to chronically alcohol-fed rats offers protection against alcohol-induced alterations. The active tannoid principles and nitric oxide scavenging compounds present in EFE may have contributed to the protection observed.

Authors+Show Affiliations

Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19459733

Citation

Reddy, V Damodara, et al. "Emblica Officinalis Protects Against Alcohol-induced Liver Mitochondrial Dysfunction in Rats." Journal of Medicinal Food, vol. 12, no. 2, 2009, pp. 327-33.
Reddy VD, Padmavathi P, Varadacharyulu NCh. Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats. J Med Food. 2009;12(2):327-33.
Reddy, V. D., Padmavathi, P., & Varadacharyulu, N. C. h. (2009). Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats. Journal of Medicinal Food, 12(2), 327-33. https://doi.org/10.1089/jmf.2007.0694
Reddy VD, Padmavathi P, Varadacharyulu NCh. Emblica Officinalis Protects Against Alcohol-induced Liver Mitochondrial Dysfunction in Rats. J Med Food. 2009;12(2):327-33. PubMed PMID: 19459733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats. AU - Reddy,V Damodara, AU - Padmavathi,P, AU - Varadacharyulu,N Ch, PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2009/9/11/medline SP - 327 EP - 33 JF - Journal of medicinal food JO - J Med Food VL - 12 IS - 2 N2 - The protective effect of Emblica officinalis, a commonly used botanical in many Ayurvedic preparations, was investigated for its effects on liver mitochondria of ethanol-administered rats. Oxidative stress and reactive oxygen species-mediated toxicity are considered two of the key underlying mechanisms responsible for alcohol-induced liver injury and mitochondrial dysfunction. Alcohol-administered rats showed a significant elevation of plasma transaminases (aspartate and alanine aminotransferases), alkaline phosphatase, and gamma-glutamyl transferase compared to control rats. However, activities of hepatic mitochondrial antioxidant enzymes, viz., superoxide dismutase, glutathione peroxidase, and reduced glutathione, were significantly lower. Chronic alcohol feeding also increased lipid peroxide levels, protein carbonyl content, and overproduction of nitric oxide followed by lowered activities of NADH dehydrogenase, succinate dehydrogenase (SDH), and cytochrome c oxidase and content of cytochromes. Administration of E. officinalis fruit extract (EFE) at a dose of 250 mg/kg of body weight/day to alcoholic rats offers protection by simultaneously lowering the carbonyl content and lipid peroxidation and elevating antioxidant enzyme activities, SDH, NADH dehydrogenase, and cytochrome c oxidase activities, and content of cytochromes in hepatic mitochondria. Our data indicate that EFE administration to chronically alcohol-fed rats offers protection against alcohol-induced alterations. The active tannoid principles and nitric oxide scavenging compounds present in EFE may have contributed to the protection observed. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/19459733/Emblica_officinalis_protects_against_alcohol_induced_liver_mitochondrial_dysfunction_in_rats_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2007.0694?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -