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Conscious sedation of pediatric dental patients: an investigation of chloral hydrate, hydroxyzine pamoate, and meperidine vs. chloral hydrate and hydroxyzine pamoate.
Pediatr Dent 1991 Jan-Feb; 13(1):10-9PD

Abstract

This study evaluated two oral sedative regimens for the conscious sedation of pediatric dental patients (mean age 37.0 months) unmanageable by traditional behavior management techniques. Regimen A included chloral hydrate (Noctec--E.R. Squibb and Sons, Princeton, NJ) at 50 mg/kg with 25 mg hydroxyzine pamoate (Vistaril--Pfizer Laboratories, New York, NY), plus meperidine (Demerol--Winthrop-Breon, New York, NY) at 1.5 mg/kg. Regimen B included chloral hydrate at 50 mg/kg with 25 mg hydroxyzine pamoate. In a crossover research design, 10 patients were assigned randomly to receive one regimen, to be followed by the alternative regimen during the second appointment. The primary purpose of this study was to determine if meperidine would improve patient behavior, and increase the prevalence of respiratory compromise. A secondary purpose of the study was to develop an objective method to assess behavior during the conscious sedation of pediatric dental patients. Results revealed that the addition of oral meperidine to chloral hydrate and hydroxyzine pamoate resulted in improved behavior (P less than 0.01) during local anesthetic injection, rubber dam delivery, and the operative dental procedure. There was no increase in the prevalence of respiratory compromise with the addition of meperidine.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1945978

Citation

Hasty, M F., et al. "Conscious Sedation of Pediatric Dental Patients: an Investigation of Chloral Hydrate, Hydroxyzine Pamoate, and Meperidine Vs. Chloral Hydrate and Hydroxyzine Pamoate." Pediatric Dentistry, vol. 13, no. 1, 1991, pp. 10-9.
Hasty MF, Vann WF, Dilley DC, et al. Conscious sedation of pediatric dental patients: an investigation of chloral hydrate, hydroxyzine pamoate, and meperidine vs. chloral hydrate and hydroxyzine pamoate. Pediatr Dent. 1991;13(1):10-9.
Hasty, M. F., Vann, W. F., Dilley, D. C., & Anderson, J. A. (1991). Conscious sedation of pediatric dental patients: an investigation of chloral hydrate, hydroxyzine pamoate, and meperidine vs. chloral hydrate and hydroxyzine pamoate. Pediatric Dentistry, 13(1), pp. 10-9.
Hasty MF, et al. Conscious Sedation of Pediatric Dental Patients: an Investigation of Chloral Hydrate, Hydroxyzine Pamoate, and Meperidine Vs. Chloral Hydrate and Hydroxyzine Pamoate. Pediatr Dent. 1991;13(1):10-9. PubMed PMID: 1945978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conscious sedation of pediatric dental patients: an investigation of chloral hydrate, hydroxyzine pamoate, and meperidine vs. chloral hydrate and hydroxyzine pamoate. AU - Hasty,M F, AU - Vann,W F,Jr AU - Dilley,D C, AU - Anderson,J A, PY - 1991/1/11/pubmed PY - 2001/3/28/medline PY - 1991/1/11/entrez SP - 10 EP - 9 JF - Pediatric dentistry JO - Pediatr Dent VL - 13 IS - 1 N2 - This study evaluated two oral sedative regimens for the conscious sedation of pediatric dental patients (mean age 37.0 months) unmanageable by traditional behavior management techniques. Regimen A included chloral hydrate (Noctec--E.R. Squibb and Sons, Princeton, NJ) at 50 mg/kg with 25 mg hydroxyzine pamoate (Vistaril--Pfizer Laboratories, New York, NY), plus meperidine (Demerol--Winthrop-Breon, New York, NY) at 1.5 mg/kg. Regimen B included chloral hydrate at 50 mg/kg with 25 mg hydroxyzine pamoate. In a crossover research design, 10 patients were assigned randomly to receive one regimen, to be followed by the alternative regimen during the second appointment. The primary purpose of this study was to determine if meperidine would improve patient behavior, and increase the prevalence of respiratory compromise. A secondary purpose of the study was to develop an objective method to assess behavior during the conscious sedation of pediatric dental patients. Results revealed that the addition of oral meperidine to chloral hydrate and hydroxyzine pamoate resulted in improved behavior (P less than 0.01) during local anesthetic injection, rubber dam delivery, and the operative dental procedure. There was no increase in the prevalence of respiratory compromise with the addition of meperidine. SN - 0164-1263 UR - https://www.unboundmedicine.com/medline/citation/1945978/Conscious_sedation_of_pediatric_dental_patients:_an_investigation_of_chloral_hydrate_hydroxyzine_pamoate_and_meperidine_vs__chloral_hydrate_and_hydroxyzine_pamoate_ DB - PRIME DP - Unbound Medicine ER -