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Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children-the LOOK study.
Pediatr Diabetes. 2009 Dec; 10(8):500-7.PD

Abstract

BACKGROUND

Knowledge of individual changes in insulin resistance (IR) and longitudinal relationships of IR with lifestyle-associated factors are of important practical significance, but little longitudinal data exist in asymptomatic children. We aimed to determine (a) changes in the homeostatic model of insulin resistance (HOMA-IR) over a 2-yr period and (b) comparisons of longitudinal and cross-sectional relationships between HOMA-IR and lifestyle-related risk factors.

METHODS

Our subjects, 241 boys and 257 girls, were assessed at age 8.1 yr (SD 0.35) and again 2 yr later for fasting blood glucose and insulin, dual X-ray absorptiometry-assessed percentage of body fat (%BF), pedometer-assessed physical activity (PA), and cardio-respiratory fitness (CRF) by multistage running test.

RESULTS

HOMA-IR was initially 9% greater in girls than boys and 27% greater 2 yr later. There was no evidence of longitudinal relationships between HOMA-IR and %BF in boys or girls, despite significant cross-sectional relationships (p < 0.001). In boys, there was evidence of a longitudinal relationship between HOMA-IR and both PA (p < 0.001) and CRF (p = 0.05). In girls, we found a cross-sectional relationship between HOMA-IR and CRF (p < 0.001).

CONCLUSIONS

HOMA-IR increases between 8 and 10 yr of age and to a greater extent in girls. Longitudinal, unlike cross-sectional, relationships do not support the premise that body fat has any impact on HOMA-IR during this period or that PA or CRF changes affect HOMA-IR in girls. These data draw attention to difficulties in interpreting observational studies in young children.

Authors+Show Affiliations

Medical School, Australian National University and Commonwealth Institute, Canberra, ACT, Australia. rtelford@cominst.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19460124

Citation

Telford, Richard D., et al. "Contrasting Longitudinal and Cross-sectional Relationships Between Insulin Resistance and Percentage of Body Fat, Fitness, and Physical Activity in Children-the LOOK Study." Pediatric Diabetes, vol. 10, no. 8, 2009, pp. 500-7.
Telford RD, Cunningham RB, Shaw JE, et al. Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children-the LOOK study. Pediatr Diabetes. 2009;10(8):500-7.
Telford, R. D., Cunningham, R. B., Shaw, J. E., Dunstan, D. W., Lafferty, A. R., Reynolds, G. J., Hickman, P. E., Southcott, E., Potter, J. M., Waring, P., & Telford, R. M. (2009). Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children-the LOOK study. Pediatric Diabetes, 10(8), 500-7. https://doi.org/10.1111/j.1399-5448.2009.00513.x
Telford RD, et al. Contrasting Longitudinal and Cross-sectional Relationships Between Insulin Resistance and Percentage of Body Fat, Fitness, and Physical Activity in Children-the LOOK Study. Pediatr Diabetes. 2009;10(8):500-7. PubMed PMID: 19460124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children-the LOOK study. AU - Telford,Richard D, AU - Cunningham,Ross B, AU - Shaw,Jonathan E, AU - Dunstan,David W, AU - Lafferty,Antony R A, AU - Reynolds,Graham J, AU - Hickman,Peter E, AU - Southcott,Emma, AU - Potter,Julia M, AU - Waring,Paul, AU - Telford,Rohan M, Y1 - 2009/04/30/ PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2010/2/18/medline SP - 500 EP - 7 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 10 IS - 8 N2 - BACKGROUND: Knowledge of individual changes in insulin resistance (IR) and longitudinal relationships of IR with lifestyle-associated factors are of important practical significance, but little longitudinal data exist in asymptomatic children. We aimed to determine (a) changes in the homeostatic model of insulin resistance (HOMA-IR) over a 2-yr period and (b) comparisons of longitudinal and cross-sectional relationships between HOMA-IR and lifestyle-related risk factors. METHODS: Our subjects, 241 boys and 257 girls, were assessed at age 8.1 yr (SD 0.35) and again 2 yr later for fasting blood glucose and insulin, dual X-ray absorptiometry-assessed percentage of body fat (%BF), pedometer-assessed physical activity (PA), and cardio-respiratory fitness (CRF) by multistage running test. RESULTS: HOMA-IR was initially 9% greater in girls than boys and 27% greater 2 yr later. There was no evidence of longitudinal relationships between HOMA-IR and %BF in boys or girls, despite significant cross-sectional relationships (p < 0.001). In boys, there was evidence of a longitudinal relationship between HOMA-IR and both PA (p < 0.001) and CRF (p = 0.05). In girls, we found a cross-sectional relationship between HOMA-IR and CRF (p < 0.001). CONCLUSIONS: HOMA-IR increases between 8 and 10 yr of age and to a greater extent in girls. Longitudinal, unlike cross-sectional, relationships do not support the premise that body fat has any impact on HOMA-IR during this period or that PA or CRF changes affect HOMA-IR in girls. These data draw attention to difficulties in interpreting observational studies in young children. SN - 1399-5448 UR - https://www.unboundmedicine.com/medline/citation/19460124/Contrasting_longitudinal_and_cross_sectional_relationships_between_insulin_resistance_and_percentage_of_body_fat_fitness_and_physical_activity_in_children_the_LOOK_study_ L2 - https://doi.org/10.1111/j.1399-5448.2009.00513.x DB - PRIME DP - Unbound Medicine ER -