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Isolation and genetic characterization of avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China.
Biochem Biophys Res Commun 2009; 386(2):278-83BB

Abstract

As pigs are susceptible to both human and avian influenza viruses, they have been proposed to be intermediate hosts or mixing vessels for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we reported avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. Homology and phylogenetic analyses showed that the H1N1 virus (A/swine/Zhejiang/1/07) was closely to avian-like H1N1 viruses and seemed to be derived from the European swine H1N1 viruses, which was for the first time reported in China; and the two H1N2 viruses (A/swine/Shanghai/1/07 and A/swine/Guangxi/13/06) were novel ressortant H1N2 influenza viruses containing genes from the classical swine (HA, NP, M and NS), human (NA and PB1) and avian (PB2 and PA) lineages, which indicted that the reassortment among human, avian, and swine influenza viruses had taken place in pigs in China and resulted in the generation of new viruses. The isolation of avian-like H1N1 influenza virus originated from the European swine H1N1 viruses, especially the emergence of two novel ressortant H1N2 influenza viruses provides further evidence that pigs serve as intermediate hosts or "mixing vessels", and swine influenza virus surveillance in China should be given a high priority.

Authors+Show Affiliations

Division of Swine Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518, Ziyue Road, Minhang District, Shanghai 200241, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19460353

Citation

Yu, Hai, et al. "Isolation and Genetic Characterization of Avian-like H1N1 and Novel Ressortant H1N2 Influenza Viruses From Pigs in China." Biochemical and Biophysical Research Communications, vol. 386, no. 2, 2009, pp. 278-83.
Yu H, Zhang PC, Zhou YJ, et al. Isolation and genetic characterization of avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. Biochem Biophys Res Commun. 2009;386(2):278-83.
Yu, H., Zhang, P. C., Zhou, Y. J., Li, G. X., Pan, J., Yan, L. P., ... Tong, G. Z. (2009). Isolation and genetic characterization of avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. Biochemical and Biophysical Research Communications, 386(2), pp. 278-83. doi:10.1016/j.bbrc.2009.05.056.
Yu H, et al. Isolation and Genetic Characterization of Avian-like H1N1 and Novel Ressortant H1N2 Influenza Viruses From Pigs in China. Biochem Biophys Res Commun. 2009 Aug 21;386(2):278-83. PubMed PMID: 19460353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and genetic characterization of avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. AU - Yu,Hai, AU - Zhang,Peng-Chao, AU - Zhou,Yan-Jun, AU - Li,Guo-Xin, AU - Pan,Jie, AU - Yan,Li-Ping, AU - Shi,Xiao-Xiao, AU - Liu,Hui-Li, AU - Tong,Guang-Zhi, Y1 - 2009/05/19/ PY - 2009/05/02/received PY - 2009/05/14/accepted PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2009/7/28/medline SP - 278 EP - 83 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 386 IS - 2 N2 - As pigs are susceptible to both human and avian influenza viruses, they have been proposed to be intermediate hosts or mixing vessels for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we reported avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. Homology and phylogenetic analyses showed that the H1N1 virus (A/swine/Zhejiang/1/07) was closely to avian-like H1N1 viruses and seemed to be derived from the European swine H1N1 viruses, which was for the first time reported in China; and the two H1N2 viruses (A/swine/Shanghai/1/07 and A/swine/Guangxi/13/06) were novel ressortant H1N2 influenza viruses containing genes from the classical swine (HA, NP, M and NS), human (NA and PB1) and avian (PB2 and PA) lineages, which indicted that the reassortment among human, avian, and swine influenza viruses had taken place in pigs in China and resulted in the generation of new viruses. The isolation of avian-like H1N1 influenza virus originated from the European swine H1N1 viruses, especially the emergence of two novel ressortant H1N2 influenza viruses provides further evidence that pigs serve as intermediate hosts or "mixing vessels", and swine influenza virus surveillance in China should be given a high priority. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/19460353/Isolation_and_genetic_characterization_of_avian_like_H1N1_and_novel_ressortant_H1N2_influenza_viruses_from_pigs_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(09)01008-0 DB - PRIME DP - Unbound Medicine ER -