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[Analysis of the clinical outcomes of IVF-ET treatment in infertile patients with polycystic ovary syndrome or polycystic ovaries].
Nan Fang Yi Ke Da Xue Xue Bao 2009; 29(5):962-5NF

Abstract

OBJECTIVE

To study the clinical features and outcomes of in vitro fertilization and embryo transfer (IVF-ET) in infertile patients due to polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO).

METHODS

This study involved 189 infertile patients with polycystic ovary syndrome (PCOS), with 129 polycystic ovaries (PCO), and 142 without PCOS or PCO (control) undergoing IVF-ET. The dosage of gonadotrophin (Gn), sex hormone level on the day of HCG administration, clinical pregnancy rate, spontaneous abortion rate and ovarian hyperstimulation syndrome (OHSS) rate were analyzed and compared between the 3 groups.

RESULTS

No significant differences were found in the clinical pregnancy rate between the PCOS group (202 cycles), PCO group (134 cycles) and control group (150 cycles) (51.0%, 53.0% and 46.0%, respectively). The levels of LH and T and early spontaneous abortion rates were significantly higher in PCOS group than in PCO group and control group (P<0.05). The P level on HCG day was the highest in PCO group (P<0.05). The early spontaneous abortion rates and clinical pregnancy rate showed no significant differences between PCO group and control group (P>0.05). The dosage of Gn was significantly lower and OHSS rate higher in PCOS and PCO groups than in the control group (P<0.05).

CONCLUSIONS

The clinical pregnancy rate of infertile patients with PCOS is similar with that of PCO patients and control patients undergoing IVF-ET treatment. PCOS, however, is associated with increased spontaneous abortion rate, possibly due to abnormality of LH and T release. The clinical outcomes in PCO patients are similar with those in the control patients, and elevated P level in the late follicular phase does not obviously influence the outcomes of IVF. Both PCOS and PCO are associated with increased risk of OHSS.

Authors+Show Affiliations

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. qingling17 @163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19460721

Citation

Wang, Qing-ling, et al. "[Analysis of the Clinical Outcomes of IVF-ET Treatment in Infertile Patients With Polycystic Ovary Syndrome or Polycystic Ovaries]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 29, no. 5, 2009, pp. 962-5.
Wang QL, Song J, Chen SL, et al. [Analysis of the clinical outcomes of IVF-ET treatment in infertile patients with polycystic ovary syndrome or polycystic ovaries]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(5):962-5.
Wang, Q. L., Song, J., Chen, S. L., Luo, C., Chen, X., Li, M., & Ni, Y. P. (2009). [Analysis of the clinical outcomes of IVF-ET treatment in infertile patients with polycystic ovary syndrome or polycystic ovaries]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 29(5), pp. 962-5.
Wang QL, et al. [Analysis of the Clinical Outcomes of IVF-ET Treatment in Infertile Patients With Polycystic Ovary Syndrome or Polycystic Ovaries]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(5):962-5. PubMed PMID: 19460721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of the clinical outcomes of IVF-ET treatment in infertile patients with polycystic ovary syndrome or polycystic ovaries]. AU - Wang,Qing-ling, AU - Song,Juan, AU - Chen,Shi-ling, AU - Luo,Chen, AU - Chen,Xin, AU - Li,Min, AU - Ni,Yun-ping, PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2010/5/5/medline SP - 962 EP - 5 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 29 IS - 5 N2 - OBJECTIVE: To study the clinical features and outcomes of in vitro fertilization and embryo transfer (IVF-ET) in infertile patients due to polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO). METHODS: This study involved 189 infertile patients with polycystic ovary syndrome (PCOS), with 129 polycystic ovaries (PCO), and 142 without PCOS or PCO (control) undergoing IVF-ET. The dosage of gonadotrophin (Gn), sex hormone level on the day of HCG administration, clinical pregnancy rate, spontaneous abortion rate and ovarian hyperstimulation syndrome (OHSS) rate were analyzed and compared between the 3 groups. RESULTS: No significant differences were found in the clinical pregnancy rate between the PCOS group (202 cycles), PCO group (134 cycles) and control group (150 cycles) (51.0%, 53.0% and 46.0%, respectively). The levels of LH and T and early spontaneous abortion rates were significantly higher in PCOS group than in PCO group and control group (P<0.05). The P level on HCG day was the highest in PCO group (P<0.05). The early spontaneous abortion rates and clinical pregnancy rate showed no significant differences between PCO group and control group (P>0.05). The dosage of Gn was significantly lower and OHSS rate higher in PCOS and PCO groups than in the control group (P<0.05). CONCLUSIONS: The clinical pregnancy rate of infertile patients with PCOS is similar with that of PCO patients and control patients undergoing IVF-ET treatment. PCOS, however, is associated with increased spontaneous abortion rate, possibly due to abnormality of LH and T release. The clinical outcomes in PCO patients are similar with those in the control patients, and elevated P level in the late follicular phase does not obviously influence the outcomes of IVF. Both PCOS and PCO are associated with increased risk of OHSS. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/19460721/[Analysis_of_the_clinical_outcomes_of_IVF_ET_treatment_in_infertile_patients_with_polycystic_ovary_syndrome_or_polycystic_ovaries]_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -