Tags

Type your tag names separated by a space and hit enter

Pharmacological dose of vitamin B12 is as effective as low-dose folinic acid in correcting hyperhomocysteinemia of hemodialysis patients.
Ren Fail 2009; 31(4):278-83RF

Abstract

Various regimens of folic acid-based and vitamin B12 (Vit B12) supplementations have been tried for lowering plasma homocysteine (Hcy) levels in uremic patients. However, the therapeutic potency of low-dose folic acid and Vit B12 alone is not properly understood. In this study, seventy-five patients on chronic hemodialysis (HD) therapy were randomized into three groups. The FNA group received intravenous (IV) supplementation with folinic acid 3 mg weekly; the Vit B12 group received IV supplementation with vitamin B12 1 mg weekly; and the combination group received IV supplementation with both agents weekly. Blood levels of Hcy, folic acid, and Vit B12 were measured monthly for three months. After three months of treatment, plasma levels of Hcy decreased significantly in all three groups when compared with their baselines (all p < 0.05). The final Hcy level was significantly lower in the combination group (11.5 +/- 2.3 micromol/L) when compared with that of the FNA group (15.9 +/- 5.6 micromol/L, p < 0.05) but not with the Vit B12 group (15.9 +/- 11.6 micromol/L), although their baseline levels were similar. The percentage decreases of tHcy at the end of the treatment in the FNA group, Vit B12 group, and combination group were 16.4%, 29.3%, and 38.9% respectively. Our study showed that IV pharmacologic dose of Vit B12 alone is as effective as low-dose folic acid in correcting hyperhomocysteinemia in chronic HD patients, and combining both drugs in low doses may have added effects.

Authors+Show Affiliations

Division of Nephrology, Departments of Internal Medicine and Renal Care, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19462276

Citation

Chiu, Yi-Wen, et al. "Pharmacological Dose of Vitamin B12 Is as Effective as Low-dose Folinic Acid in Correcting Hyperhomocysteinemia of Hemodialysis Patients." Renal Failure, vol. 31, no. 4, 2009, pp. 278-83.
Chiu YW, Chang JM, Hwang SJ, et al. Pharmacological dose of vitamin B12 is as effective as low-dose folinic acid in correcting hyperhomocysteinemia of hemodialysis patients. Ren Fail. 2009;31(4):278-83.
Chiu, Y. W., Chang, J. M., Hwang, S. J., Tsai, J. C., & Chen, H. C. (2009). Pharmacological dose of vitamin B12 is as effective as low-dose folinic acid in correcting hyperhomocysteinemia of hemodialysis patients. Renal Failure, 31(4), pp. 278-83. doi:10.1080/08860220902780010.
Chiu YW, et al. Pharmacological Dose of Vitamin B12 Is as Effective as Low-dose Folinic Acid in Correcting Hyperhomocysteinemia of Hemodialysis Patients. Ren Fail. 2009;31(4):278-83. PubMed PMID: 19462276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological dose of vitamin B12 is as effective as low-dose folinic acid in correcting hyperhomocysteinemia of hemodialysis patients. AU - Chiu,Yi-Wen, AU - Chang,Jer-Ming, AU - Hwang,Shang-Jyh, AU - Tsai,Jer-Chia, AU - Chen,Hung-Chun, PY - 2009/5/23/entrez PY - 2009/5/23/pubmed PY - 2009/8/25/medline SP - 278 EP - 83 JF - Renal failure JO - Ren Fail VL - 31 IS - 4 N2 - Various regimens of folic acid-based and vitamin B12 (Vit B12) supplementations have been tried for lowering plasma homocysteine (Hcy) levels in uremic patients. However, the therapeutic potency of low-dose folic acid and Vit B12 alone is not properly understood. In this study, seventy-five patients on chronic hemodialysis (HD) therapy were randomized into three groups. The FNA group received intravenous (IV) supplementation with folinic acid 3 mg weekly; the Vit B12 group received IV supplementation with vitamin B12 1 mg weekly; and the combination group received IV supplementation with both agents weekly. Blood levels of Hcy, folic acid, and Vit B12 were measured monthly for three months. After three months of treatment, plasma levels of Hcy decreased significantly in all three groups when compared with their baselines (all p < 0.05). The final Hcy level was significantly lower in the combination group (11.5 +/- 2.3 micromol/L) when compared with that of the FNA group (15.9 +/- 5.6 micromol/L, p < 0.05) but not with the Vit B12 group (15.9 +/- 11.6 micromol/L), although their baseline levels were similar. The percentage decreases of tHcy at the end of the treatment in the FNA group, Vit B12 group, and combination group were 16.4%, 29.3%, and 38.9% respectively. Our study showed that IV pharmacologic dose of Vit B12 alone is as effective as low-dose folic acid in correcting hyperhomocysteinemia in chronic HD patients, and combining both drugs in low doses may have added effects. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/19462276/Pharmacological_dose_of_vitamin_B12_is_as_effective_as_low_dose_folinic_acid_in_correcting_hyperhomocysteinemia_of_hemodialysis_patients_ L2 - http://www.tandfonline.com/doi/full/10.1080/08860220902780010 DB - PRIME DP - Unbound Medicine ER -