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Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury.
Pharmacol Biochem Behav. 2009 May; 92(3):457-64.PB

Abstract

In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-allodynic and anti-hyperalgesic effects of these drugs, administered either separately or in combination, were determined using the von Frey and acetone tests in a rat model of neuropathic pain (Bennett model). Morphine and gabapentin individually induced moderate attenuation of mechanical hyperalgesia, whereas the morphine and gabapentin combination completely decreased hyperalgesia. Morphine showed its maximal effect at 30 min post-injection in the acetone test; however, this effect gradually returned to the baseline value. Gabapentin did not produce an anti-allodynic effect, whereas the morphine and gabapentin combination completely decreased allodynia behavior at 30 min post-injection, an effect that persisted until 120 min. The area under the curve (AUC) of the anti-allodynic or anti-hyperalgesic effects produced by the combinations were significantly greater than the theoretical sum of effects produced by each drug alone or similar to the theoretical sum. The analysis of the effect, expressed as the AUC of the time course, supports the hypothesis that the combination of these drugs is useful in neuropathic pain therapy.

Authors+Show Affiliations

Departamento de Farmacobiología, Cinvestav-Sede Sur, México D.F., México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19463259

Citation

De la O-Arciniega, Minarda, et al. "Anti-nociceptive Synergism of Morphine and Gabapentin in Neuropathic Pain Induced By Chronic Constriction Injury." Pharmacology, Biochemistry, and Behavior, vol. 92, no. 3, 2009, pp. 457-64.
De la O-Arciniega M, Díaz-Reval MI, Cortés-Arroyo AR, et al. Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury. Pharmacol Biochem Behav. 2009;92(3):457-64.
De la O-Arciniega, M., Díaz-Reval, M. I., Cortés-Arroyo, A. R., Domínguez-Ramírez, A. M., & López-Muñoz, F. J. (2009). Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury. Pharmacology, Biochemistry, and Behavior, 92(3), 457-64. https://doi.org/10.1016/j.pbb.2009.01.013
De la O-Arciniega M, et al. Anti-nociceptive Synergism of Morphine and Gabapentin in Neuropathic Pain Induced By Chronic Constriction Injury. Pharmacol Biochem Behav. 2009;92(3):457-64. PubMed PMID: 19463259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury. AU - De la O-Arciniega,Minarda, AU - Díaz-Reval,Ma Irene, AU - Cortés-Arroyo,Alma Rosa, AU - Domínguez-Ramírez,Adriana Miriam, AU - López-Muñoz,Francisco Javier, Y1 - 2009/01/23/ PY - 2008/07/28/received PY - 2009/01/12/revised PY - 2009/01/17/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/8/6/medline SP - 457 EP - 64 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 92 IS - 3 N2 - In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-allodynic and anti-hyperalgesic effects of these drugs, administered either separately or in combination, were determined using the von Frey and acetone tests in a rat model of neuropathic pain (Bennett model). Morphine and gabapentin individually induced moderate attenuation of mechanical hyperalgesia, whereas the morphine and gabapentin combination completely decreased hyperalgesia. Morphine showed its maximal effect at 30 min post-injection in the acetone test; however, this effect gradually returned to the baseline value. Gabapentin did not produce an anti-allodynic effect, whereas the morphine and gabapentin combination completely decreased allodynia behavior at 30 min post-injection, an effect that persisted until 120 min. The area under the curve (AUC) of the anti-allodynic or anti-hyperalgesic effects produced by the combinations were significantly greater than the theoretical sum of effects produced by each drug alone or similar to the theoretical sum. The analysis of the effect, expressed as the AUC of the time course, supports the hypothesis that the combination of these drugs is useful in neuropathic pain therapy. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/19463259/Anti_nociceptive_synergism_of_morphine_and_gabapentin_in_neuropathic_pain_induced_by_chronic_constriction_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(09)00040-9 DB - PRIME DP - Unbound Medicine ER -