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Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats.
Behav Brain Res. 2009 Sep 14; 202(2):260-5.BB

Abstract

Drug addiction is a chronic disorder characterized by a relatively high rate of relapse even after long period of abstinence. In the present study, we used the conditioned place preference (CPP) paradigm to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats. Nicotine produced a place preference to the initially less-preferred compartment paired with its injections during conditioning (0.5mg/kg, i.p., three drug sessions). Once established, nicotine CPP was extinguished by repeated testing. Following this extinction phase, the reinstatement of CPP was investigated. Nicotine-experienced rats were challenged with nicotine (0.5mg/kg, i.p.) or morphine (10mg/kg, i.p.). These priming injections of both drugs induced a marked preference for the compartment previously paired with nicotine. Furthermore, the objective of the present study was to evaluate the efficacy of CB1 cannabinoid receptor antagonist rimonabant (0.5, 1 and 2mg/kg, i.p.) in blocking the reinstatement of nicotine-induced CPP provoked by nicotine and morphine. It was shown that rimonabant attenuated the reinstatement of nicotine-conditioned response induced by both drugs. The outcome of our studies may suggest that CB1 receptor antagonists may become a promising target for effective pharmacotherapy of tobacco addiction and polydrug abuse.

Authors+Show Affiliations

Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4 Staszica Street, 20-081 Lublin, Poland. grazyna.biala@am.lublin.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19463710

Citation

Biala, Grazyna, et al. "Effects of Rimonabant On the Reinstatement of Nicotine-conditioned Place Preference By Drug Priming in Rats." Behavioural Brain Research, vol. 202, no. 2, 2009, pp. 260-5.
Biala G, Budzynska B, Staniak N. Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Behav Brain Res. 2009;202(2):260-5.
Biala, G., Budzynska, B., & Staniak, N. (2009). Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Behavioural Brain Research, 202(2), 260-5. https://doi.org/10.1016/j.bbr.2009.03.042
Biala G, Budzynska B, Staniak N. Effects of Rimonabant On the Reinstatement of Nicotine-conditioned Place Preference By Drug Priming in Rats. Behav Brain Res. 2009 Sep 14;202(2):260-5. PubMed PMID: 19463710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats. AU - Biala,Grazyna, AU - Budzynska,Barbara, AU - Staniak,Natasza, Y1 - 2009/04/08/ PY - 2008/12/22/received PY - 2009/03/30/revised PY - 2009/03/31/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/8/20/medline SP - 260 EP - 5 JF - Behavioural brain research JO - Behav Brain Res VL - 202 IS - 2 N2 - Drug addiction is a chronic disorder characterized by a relatively high rate of relapse even after long period of abstinence. In the present study, we used the conditioned place preference (CPP) paradigm to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats. Nicotine produced a place preference to the initially less-preferred compartment paired with its injections during conditioning (0.5mg/kg, i.p., three drug sessions). Once established, nicotine CPP was extinguished by repeated testing. Following this extinction phase, the reinstatement of CPP was investigated. Nicotine-experienced rats were challenged with nicotine (0.5mg/kg, i.p.) or morphine (10mg/kg, i.p.). These priming injections of both drugs induced a marked preference for the compartment previously paired with nicotine. Furthermore, the objective of the present study was to evaluate the efficacy of CB1 cannabinoid receptor antagonist rimonabant (0.5, 1 and 2mg/kg, i.p.) in blocking the reinstatement of nicotine-induced CPP provoked by nicotine and morphine. It was shown that rimonabant attenuated the reinstatement of nicotine-conditioned response induced by both drugs. The outcome of our studies may suggest that CB1 receptor antagonists may become a promising target for effective pharmacotherapy of tobacco addiction and polydrug abuse. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19463710/Effects_of_rimonabant_on_the_reinstatement_of_nicotine_conditioned_place_preference_by_drug_priming_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00216-2 DB - PRIME DP - Unbound Medicine ER -