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Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways.
Biochem Biophys Res Commun. 2009 Jul 31; 385(3):357-62.BB

Abstract

Extensive alteration of gene expression and metabolic remodeling enable the budding yeast Saccharomyces cerevisiae to ensure cellular homeostasis and adaptation to heat shock. The response logic of the cells to heat shock is still not entirely clear. In this study, we combined the expression profiles with metabolic pathways to investigate the logical relations between heat shock response metabolic pathways. The results showed that the heat-stressed S. cerevisiae cell accumulated trehalose and glycogen, which protect cellular proteins against denaturation, and modulate its phospholipid structure to sustain stability of the cell wall. The TCA cycle was enhanced, and the heat shock-induced turnover of amino acids and nucleotides served to meet the extra energy requirement due to heat-induced protein metabolism and modification. The enhanced respiration led to oxidative stress, and subsequently induced the aldehyde detoxification system. These results indicated that new insight into the response logic of S. cerevisiae to heat shock can be gained by integrating expression profiles and the logical relations between heat shock response metabolic pathways.

Authors+Show Affiliations

School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19463789

Citation

Ye, Yanrui, et al. "Gaining Insight Into the Response Logic of Saccharomyces Cerevisiae to Heat Shock By Combining Expression Profiles With Metabolic Pathways." Biochemical and Biophysical Research Communications, vol. 385, no. 3, 2009, pp. 357-62.
Ye Y, Zhu Y, Pan L, et al. Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways. Biochem Biophys Res Commun. 2009;385(3):357-62.
Ye, Y., Zhu, Y., Pan, L., Li, L., Wang, X., & Lin, Y. (2009). Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways. Biochemical and Biophysical Research Communications, 385(3), 357-62. https://doi.org/10.1016/j.bbrc.2009.05.071
Ye Y, et al. Gaining Insight Into the Response Logic of Saccharomyces Cerevisiae to Heat Shock By Combining Expression Profiles With Metabolic Pathways. Biochem Biophys Res Commun. 2009 Jul 31;385(3):357-62. PubMed PMID: 19463789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways. AU - Ye,Yanrui, AU - Zhu,Yi, AU - Pan,Li, AU - Li,Lili, AU - Wang,Xiaoning, AU - Lin,Ying, Y1 - 2009/05/20/ PY - 2009/05/03/received PY - 2009/05/13/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/7/1/medline SP - 357 EP - 62 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 385 IS - 3 N2 - Extensive alteration of gene expression and metabolic remodeling enable the budding yeast Saccharomyces cerevisiae to ensure cellular homeostasis and adaptation to heat shock. The response logic of the cells to heat shock is still not entirely clear. In this study, we combined the expression profiles with metabolic pathways to investigate the logical relations between heat shock response metabolic pathways. The results showed that the heat-stressed S. cerevisiae cell accumulated trehalose and glycogen, which protect cellular proteins against denaturation, and modulate its phospholipid structure to sustain stability of the cell wall. The TCA cycle was enhanced, and the heat shock-induced turnover of amino acids and nucleotides served to meet the extra energy requirement due to heat-induced protein metabolism and modification. The enhanced respiration led to oxidative stress, and subsequently induced the aldehyde detoxification system. These results indicated that new insight into the response logic of S. cerevisiae to heat shock can be gained by integrating expression profiles and the logical relations between heat shock response metabolic pathways. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/19463789/Gaining_insight_into_the_response_logic_of_Saccharomyces_cerevisiae_to_heat_shock_by_combining_expression_profiles_with_metabolic_pathways_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(09)01005-5 DB - PRIME DP - Unbound Medicine ER -