Tags

Type your tag names separated by a space and hit enter

Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.
Antiviral Res. 2009 Aug; 83(2):186-90.AR

Abstract

Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.

Authors+Show Affiliations

Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19463857

Citation

Wang, Gui-Feng, et al. "Anti-hepatitis B Virus Activity of Chlorogenic Acid, Quinic Acid and Caffeic Acid in Vivo and in Vitro." Antiviral Research, vol. 83, no. 2, 2009, pp. 186-90.
Wang GF, Shi LP, Ren YD, et al. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res. 2009;83(2):186-90.
Wang, G. F., Shi, L. P., Ren, Y. D., Liu, Q. F., Liu, H. F., Zhang, R. J., Li, Z., Zhu, F. H., He, P. L., Tang, W., Tao, P. Z., Li, C., Zhao, W. M., & Zuo, J. P. (2009). Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Research, 83(2), 186-90. https://doi.org/10.1016/j.antiviral.2009.05.002
Wang GF, et al. Anti-hepatitis B Virus Activity of Chlorogenic Acid, Quinic Acid and Caffeic Acid in Vivo and in Vitro. Antiviral Res. 2009;83(2):186-90. PubMed PMID: 19463857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. AU - Wang,Gui-Feng, AU - Shi,Li-Ping, AU - Ren,Yu-Dan, AU - Liu,Qun-Fang, AU - Liu,Hou-Fu, AU - Zhang,Ru-Jun, AU - Li,Zhuang, AU - Zhu,Feng-Hua, AU - He,Pei-Lan, AU - Tang,Wei, AU - Tao,Pei-Zhen, AU - Li,Chuan, AU - Zhao,Wei-Min, AU - Zuo,Jian-Ping, Y1 - 2009/05/20/ PY - 2009/01/16/received PY - 2009/04/13/revised PY - 2009/05/07/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/8/4/medline SP - 186 EP - 90 JF - Antiviral research JO - Antiviral Res VL - 83 IS - 2 N2 - Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/19463857/Anti_hepatitis_B_virus_activity_of_chlorogenic_acid_quinic_acid_and_caffeic_acid_in_vivo_and_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(09)00325-8 DB - PRIME DP - Unbound Medicine ER -